Motif ID: TFAP2B.p2

Z-value: 1.649

Transcription factors associated with TFAP2B.p2:

NameEntrezDescription
Tcfap2b 21419 transcription factor AP-2 beta

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Tcfap2bchr1_+_192020460.231.8e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr8_-_87324043 3.581 NM_001081982
NM_010906
Nfix

nuclear factor I/X

chr2_+_156301543 3.004 NM_001006664
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_+_174155515 2.394 NM_201616
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr4_-_123341990 2.245 Macf1
microtubule-actin crosslinking factor 1
chr11_+_57822347 2.222 NM_028451
Larp1
La ribonucleoprotein domain family, member 1
chr10_+_81022229 2.190 Aes
amino-terminal enhancer of split
chr12_+_109792949 2.070 Evl
Ena-vasodilator stimulated phosphoprotein
chr5_+_124423712 1.815 Hip1r
huntingtin interacting protein 1 related
chr2_+_160556982 1.760 NM_021280
Plcg1
phospholipase C, gamma 1
chr13_+_51196154 1.670 NM_146043
Spin1
spindlin 1
chr17_-_24278482 1.622 NM_001080773
NM_011062
Pdpk1

3-phosphoinositide dependent protein kinase 1

chr10_-_79229589 1.585 NM_144528
Rnf126
ring finger protein 126
chr6_-_131338465 1.578 NM_011733
NM_139117
Csda

cold shock domain protein A

chr2_-_131005549 1.551 NM_007682
Cenpb
centromere protein B
chr17_-_45686604 1.466 NM_001013749
Tmem151b
transmembrane protein 151B
chr12_-_101758964 1.459 NM_001033213
Ttc7b
tetratricopeptide repeat domain 7B
chr14_+_76245144 1.450 Tpt1
tumor protein, translationally-controlled 1
chr12_+_114336416 1.447 NM_054081
Mta1
metastasis associated 1
chr2_+_154617083 1.407 Raly
a
hnRNP-associated with lethal yellow
nonagouti
chr1_+_43502537 1.365 NM_010879
Nck2
non-catalytic region of tyrosine kinase adaptor protein 2
chr15_+_89041957 1.363 NM_026813
NM_027805
Ppp6r2

protein phosphatase 6, regulatory subunit 2

chr10_+_81022304 1.358 NM_010347
Aes
amino-terminal enhancer of split
chr7_-_20044133 1.342 Mark4
MAP/microtubule affinity-regulating kinase 4
chr11_+_3102585 1.340 NM_023743
Eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr14_+_121434765 1.327 NM_134082
Farp1
FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
chr6_+_92041408 1.304 NM_011630
Nr2c2
nuclear receptor subfamily 2, group C, member 2
chr10_-_66559568 1.286 NM_178606
Reep3
receptor accessory protein 3
chr4_+_130125682 1.279 NM_025998
Nkain1
Na+/K+ transporting ATPase interacting 1
chr15_-_84686558 1.276 NM_001081166
Phf21b
PHD finger protein 21B
chr4_+_97444312 1.273 NM_001122953
NM_010905
Nfia

nuclear factor I/A

chr7_+_19661548 1.258 NM_010058
Dmwd
dystrophia myotonica-containing WD repeat motif
chr10_+_81022283 1.253 Aes
amino-terminal enhancer of split
chr4_+_97444326 1.245 Nfia
nuclear factor I/A
chr2_-_168567436 1.242 Atp9a
ATPase, class II, type 9A
chr10_-_60610398 1.215 NM_009163
Sgpl1
sphingosine phosphate lyase 1
chr1_-_134439436 1.195 Cntn2
contactin 2
chr7_+_52419317 1.193 Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr8_-_125201971 1.187 NM_001109873
NM_177289
Cbfa2t3

core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)

chr2_+_146047656 1.178 NM_016889
Insm1
insulinoma-associated 1
chr14_+_48740583 1.177 Peli2
pellino 2
chr5_-_53604673 1.172 NM_172710
Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr15_-_79272478 1.155 NM_013767
Csnk1e
casein kinase 1, epsilon
chr17_+_24625709 1.130 NM_027937
Caskin1
CASK interacting protein 1
chr11_-_6375845 1.127 NM_011221
Purb
purine rich element binding protein B
chr17_+_83614611 1.116 NM_134117
Pkdcc
protein kinase domain containing, cytoplasmic
chr13_-_48966240 1.104 NM_011078
Phf2
PHD finger protein 2
chr7_+_88138537 1.103 NM_178707
Zfp592
zinc finger protein 592
chr7_-_144506112 1.101 NM_001113414
NM_001113415
NM_010096
Ebf3


early B-cell factor 3


chr15_+_78858872 1.081 H1f0
H1 histone family, member 0
chr4_+_128404814 1.078 NM_001195083
Phc2
polyhomeotic-like 2 (Drosophila)
chr16_+_33684551 1.077 NM_175256
Heg1
HEG homolog 1 (zebrafish)
chr6_-_86476063 1.075 NM_011865
Pcbp1
poly(rC) binding protein 1
chr12_-_109417393 1.069 NM_028262
Setd3
SET domain containing 3
chr7_-_71083734 1.061 NM_021366
Klf13
Kruppel-like factor 13
chr8_+_63703064 1.060 Sh3rf1
SH3 domain containing ring finger 1
chr19_-_5098486 1.057 Cnih2
cornichon homolog 2 (Drosophila)
chr1_+_137043277 1.056 NM_026823
Arl8a
ADP-ribosylation factor-like 8A
chr7_-_150646883 1.044 NM_001161624
NM_009876
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr15_-_76352331 1.043 NM_130893
Scrt1
scratch homolog 1, zinc finger protein (Drosophila)
chr9_+_107302196 1.031 NM_001174047
NM_001174048
NM_001174049
NM_001174050
NM_020263
Cacna2d2




calcium channel, voltage-dependent, alpha 2/delta subunit 2




chr13_-_72101161 1.030 NM_010573
Irx1
Iroquois related homeobox 1 (Drosophila)
chr11_+_77306825 1.028 NM_001004144
Git1
G protein-coupled receptor kinase-interactor 1
chr13_-_58375469 1.007 NM_019832
Gkap1
G kinase anchoring protein 1
chr11_-_120442889 0.995 NM_133796
Arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr5_-_141306258 0.991 NM_010302
Gna12
guanine nucleotide binding protein, alpha 12
chr12_+_109792925 0.987 NM_001163394
NM_007965
Evl

Ena-vasodilator stimulated phosphoprotein

chr11_-_58752365 0.983 Rnf187
ring finger protein 187
chr8_-_27126047 0.981 Fnta
farnesyltransferase, CAAX box, alpha
chr13_+_41345120 0.980 NM_001135577
BC024659
cDNA sequence BC024659
chr5_+_28643698 0.980 NM_028234
Rbm33
RNA binding motif protein 33
chr14_+_48740495 0.973 NM_033602
Peli2
pellino 2
chr10_+_127896244 0.971 NM_001114096
NM_001114097
NM_198160
Smarcc2


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2


chr12_+_109793151 0.971 Evl
Ena-vasodilator stimulated phosphoprotein
chr13_-_56236756 0.965 H2afy
H2A histone family, member Y
chr5_-_33617629 0.949 Ctbp1
C-terminal binding protein 1
chr14_+_31832323 0.949 NM_001081251
Pbrm1
polybromo 1
chr11_+_80290509 0.948 NM_009871
Cdk5r1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr3_-_51144470 0.947 Elf2
E74-like factor 2
chr17_-_66450782 0.944 NM_028388
Ndufv2
NADH dehydrogenase (ubiquinone) flavoprotein 2
chr2_+_18598644 0.935 NM_007552
Bmi1
Bmi1 polycomb ring finger oncogene
chr7_+_13610047 0.927 Trim28
tripartite motif-containing 28
chr1_+_39957733 0.918 NM_008696
Map4k4
mitogen-activated protein kinase kinase kinase kinase 4
chr11_+_43342241 0.904 NM_001045530
Ccnjl
cyclin J-like
chr4_-_118966945 0.897 NM_011732
Ybx1
Y box protein 1
chr11_+_59475986 0.895 NM_012027
NM_201245
Mprip

myosin phosphatase Rho interacting protein

chr4_-_133189327 0.894 NM_001017968
Zdhhc18
zinc finger, DHHC domain containing 18
chr1_-_153937097 0.892 1700025G04Rik
RIKEN cDNA 1700025G04 gene
chr10_-_79896330 0.882 Tcf3
transcription factor 3
chr12_+_112404563 0.877 Traf3
TNF receptor-associated factor 3
chr4_-_134828503 0.875 NM_013885
Clic4
chloride intracellular channel 4 (mitochondrial)
chr5_+_34339258 0.867 Nat8l
N-acetyltransferase 8-like
chr8_-_73397377 0.865 NM_026964
Ccdc124
coiled-coil domain containing 124
chr2_+_174155506 0.864 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr6_-_72849854 0.864 NM_019715
Kcmf1
potassium channel modulatory factor 1
chr9_+_57787915 0.861 NM_011352
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr14_-_73725611 0.857 Rb1
retinoblastoma 1
chr5_-_33617631 0.856 NM_001198859
NM_001198860
NM_001198861
NM_013502
Ctbp1



C-terminal binding protein 1



chr17_-_74694322 0.851 Memo1
mediator of cell motility 1
chr2_+_29475234 0.850 NM_001039086
NM_001039087
NM_054050
Rapgef1


Rap guanine nucleotide exchange factor (GEF) 1


chr9_+_64949242 0.849 NM_020043
Igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chr8_-_97220127 0.849 NM_026385
Pllp
plasma membrane proteolipid
chr17_-_10512094 0.847 Qk
quaking
chr11_+_57615080 0.846 NM_001081168
Sap30l
SAP30-like
chr5_+_124423632 0.843 NM_145070
Hip1r
huntingtin interacting protein 1 related
chr12_+_88019649 0.839 NM_177354
Vash1
vasohibin 1
chr10_-_79862025 0.836 Mbd3
methyl-CpG binding domain protein 3
chr4_-_109149274 0.828 Rnf11
ring finger protein 11
chr2_-_156904966 0.815 NM_001164663
9830001H06Rik
RIKEN cDNA 9830001H06 gene
chr3_+_87946259 0.811 NM_133665
Mef2d
myocyte enhancer factor 2D
chr9_+_102528606 0.805 NM_181394
Anapc13
anaphase promoting complex subunit 13
chr9_+_121551833 0.803 NM_011703
Vipr1
vasoactive intestinal peptide receptor 1
chr8_-_72498210 0.802 NM_001113346
Gatad2a
GATA zinc finger domain containing 2A
chr8_+_108384479 0.800 NM_026532
Nutf2
nuclear transport factor 2
chr5_-_115140869 0.797 NM_019821
Gltp
glycolipid transfer protein
chr11_+_90110701 0.793 NM_026178
Mmd
monocyte to macrophage differentiation-associated
chr2_+_29921953 0.793 Set
SET nuclear oncogene
chr1_+_193542261 0.792 NM_001134829
Lpgat1
lysophosphatidylglycerol acyltransferase 1
chr13_-_9764195 0.788 Zmynd11
zinc finger, MYND domain containing 11
chr15_+_78858900 0.787 H1f0
H1 histone family, member 0
chr12_+_113960379 0.783 NM_001024602
AW555464
expressed sequence AW555464
chr15_+_102300972 0.782 NM_001103165
NM_001103166
NM_001174073
NM_011042
Pcbp2



poly(rC) binding protein 2



chr11_+_59476181 0.781 Mprip
myosin phosphatase Rho interacting protein
chr7_+_149135647 0.780 NM_029426
Brsk2
BR serine/threonine kinase 2
chr2_-_33743000 0.780 Fam125b
family with sequence similarity 125, member B
chr8_+_11556495 0.779 Ing1
inhibitor of growth family, member 1
chr7_+_25266986 0.773 NM_153112
Cadm4
cell adhesion molecule 4
chr4_-_45839668 0.772 NM_018741
Igfbpl1
insulin-like growth factor binding protein-like 1
chr11_+_102622885 0.769 Adam11
a disintegrin and metallopeptidase domain 11
chr12_+_112997057 0.766 NM_001025360
NM_001081959
NM_008450
Klc1


kinesin light chain 1


chr4_+_109349259 0.763 Faf1
Fas-associated factor 1
chr17_-_25410290 0.763 Ube2i
ubiquitin-conjugating enzyme E2I
chr11_+_51912342 0.760 Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
chr10_-_77815056 0.757 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr2_-_153355706 0.755 NM_001134300
8430427H17Rik
RIKEN cDNA 8430427H17 gene
chr13_-_69138418 0.754 NM_153534
Adcy2
adenylate cyclase 2
chr2_-_29701764 0.753 Gm3088
predicted gene 3088
chr5_-_5380077 0.752 NM_011074
Cdk14
cyclin-dependent kinase 14
chr10_+_126817878 0.752


chr10_+_79179326 0.748 NM_008226
Hcn2
hyperpolarization-activated, cyclic nucleotide-gated K+ 2
chr5_+_33361386 0.746 NM_011738
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr11_+_53164287 0.745 Aff4
AF4/FMR2 family, member 4
chr13_-_59658585 0.744 NM_001048008
NM_023328
Agtpbp1

ATP/GTP binding protein 1

chr18_+_52927574 0.741 Gm5078
Sncaip
predicted gene 5078
synuclein, alpha interacting protein (synphilin)
chr14_+_76245115 0.739 Tpt1
tumor protein, translationally-controlled 1
chr17_+_86567003 0.738 NM_011104
Prkce
protein kinase C, epsilon
chr5_-_115223373 0.737 NM_001077360
NM_019834
NM_001077359
Git2


G protein-coupled receptor kinase-interactor 2


chr2_+_121275069 0.733 Serf2
small EDRK-rich factor 2
chr19_-_5098498 0.732 Cnih2
cornichon homolog 2 (Drosophila)
chr9_+_51856305 0.728 Rdx
radixin
chr3_-_144382959 0.726 NM_019464
Sh3glb1
SH3-domain GRB2-like B1 (endophilin)
chr8_-_127473082 0.725 NM_053207
Egln1
EGL nine homolog 1 (C. elegans)
chr10_-_62801726 0.721 NM_001159590
NM_019812
NM_001159589
Sirt1


sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)


chr17_+_24625530 0.715 Caskin1
CASK interacting protein 1
chr10_+_79578561 0.711 Stk11
serine/threonine kinase 11
chr19_+_21346734 0.709 NM_009551
Zfand5
zinc finger, AN1-type domain 5
chr3_+_102538849 0.697 Tspan2
tetraspanin 2
chr7_-_144506091 0.696 Ebf3
early B-cell factor 3
chr9_-_102528453 0.691 NM_001081122
Cep63
centrosomal protein 63
chr12_-_113912266 0.688 NM_001165894
NM_009652
Akt1

thymoma viral proto-oncogene 1

chr4_-_134828699 0.687 Clic4
chloride intracellular channel 4 (mitochondrial)
chr1_-_156946739 0.686 NM_010500
Ier5
immediate early response 5
chr6_+_29383152 0.681 NM_001081185
Flnc
filamin C, gamma
chr7_-_72301384 0.678 NM_183087
Fam189a1
family with sequence similarity 189, member A1
chr11_-_120442851 0.678 Arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr2_-_58419558 0.677 Acvr1
activin A receptor, type 1
chr8_+_34710049 0.674 NM_017374
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr9_-_62384766 0.673 Coro2b
coronin, actin binding protein, 2B
chr8_+_119467267 0.673 NM_177700
Atmin
ATM interactor
chr19_+_42330170 0.672 NM_027694
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr15_+_80004048 0.671 NM_010795
Mgat3
mannoside acetylglucosaminyltransferase 3
chr11_+_59476016 0.670 Mprip
myosin phosphatase Rho interacting protein
chr2_-_35056446 0.670 Rab14
RAB14, member RAS oncogene family
chr8_+_126177709 0.662 NM_133955
Rhou
ras homolog gene family, member U
chr4_+_53453302 0.660 Slc44a1
solute carrier family 44, member 1
chr5_-_34530284 0.658 NM_010753
Mxd4
Max dimerization protein 4
chr3_+_89577436 0.654 NM_027315
Ube2q1
ubiquitin-conjugating enzyme E2Q (putative) 1
chr5_-_135870365 0.653 NM_148932
Pom121
nuclear pore membrane protein 121
chr13_-_112599181 0.651 NM_011945
Map3k1
mitogen-activated protein kinase kinase kinase 1
chr12_+_112776424 0.650 Eif5
eukaryotic translation initiation factor 5
chr2_-_168567422 0.647 Atp9a
ATPase, class II, type 9A
chr1_+_179372452 0.639 Zfp238
zinc finger protein 238
chr1_-_153347884 0.639 NM_011277
Rnf2
ring finger protein 2
chrX_-_154481213 0.639


chr9_-_106789330 0.638 NM_175402
Rbm15b
RNA binding motif protein 15B
chr18_-_80666366 0.637 NM_026295
Ctdp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr16_-_18235102 0.637 NM_172151
Zdhhc8
zinc finger, DHHC domain containing 8
chr12_+_17551771 0.637 Odc1
ornithine decarboxylase, structural 1
chr2_-_173102033 0.636 NM_022995
Pmepa1
prostate transmembrane protein, androgen induced 1
chr3_+_121948399 0.635 NM_008129
Gclm
glutamate-cysteine ligase, modifier subunit
chr3_+_108087046 0.634 NM_019972
Sort1
sortilin 1
chr3_+_90097105 0.634 Gatad2b
GATA zinc finger domain containing 2B
chr12_-_70284991 0.633 Rpl36al
ribosomal protein L36A-like
chr4_-_134108044 0.632 NM_029100
Sepn1
selenoprotein N, 1
chr10_+_80085486 0.631 NM_134002
Csnk1g2
casein kinase 1, gamma 2
chr4_+_46052115 0.631


chr11_-_102680467 0.629 NM_001159382
Gjc1
gap junction protein, gamma 1
chr13_-_47201478 0.628 NM_025900
Dek
DEK oncogene (DNA binding)
chr8_+_91045232 0.626 NM_027280
Nkd1
naked cuticle 1 homolog (Drosophila)
chr7_+_73007017 0.626 NM_011048
Pcsk6
proprotein convertase subtilisin/kexin type 6
chr11_-_21901563 0.625 NM_011023
Otx1
orthodenticle homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
1.74 6.56e-03 GO:0050794 regulation of cellular process
2.40 8.20e-03 GO:0060255 regulation of macromolecule metabolic process
1.66 1.02e-02 GO:0065007 biological regulation
2.21 1.24e-02 GO:0019222 regulation of metabolic process
2.57 1.36e-02 GO:0048518 positive regulation of biological process
2.32 1.44e-02 GO:0080090 regulation of primary metabolic process
1.65 2.71e-02 GO:0050789 regulation of biological process
2.54 2.75e-02 GO:0010468 regulation of gene expression
2.57 3.87e-02 GO:0048522 positive regulation of cellular process

Gene overrepresentation in compartment category:

enrichment p-value GO term description
1.54 1.51e-02 GO:0043226 organelle
1.45 1.89e-02 GO:0044424 intracellular part
1.42 3.39e-02 GO:0005622 intracellular
1.50 3.70e-02 GO:0043229 intracellular organelle
1.25 4.56e-02 GO:0005623 cell
1.25 4.56e-02 GO:0044464 cell part
1.54 4.91e-02 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

enrichment p-value GO term description
1.60 4.52e-05 GO:0005488 binding
2.06 1.90e-04 GO:0005515 protein binding
3.35 6.37e-03 GO:0008270 zinc ion binding
2.98 6.38e-03 GO:0003677 DNA binding
20.08 3.18e-02 GO:0003697 single-stranded DNA binding
60.83 3.40e-02 GO:0090079 translation regulator activity, nucleic acid binding
2.80 3.80e-02 GO:0046914 transition metal ion binding
2.32 4.12e-02 GO:0003676 nucleic acid binding