Motif ID: TFAP4.p2

Z-value: 1.287

Transcription factors associated with TFAP4.p2:

NameEntrezDescription
Tcfap4 83383 transcription factor AP4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Tcfap4chr16_-_45595110.298.9e-02Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr5_+_89315839 9.127 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr7_+_129432585 7.718 NM_008855
Prkcb
protein kinase C, beta
chr2_-_25325248 6.354 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr4_-_66065499 5.436 NM_019514
NM_207109
Astn2

astrotactin 2

chr4_-_128798481 5.081 NM_010471
Hpca
hippocalcin
chr10_+_60638341 5.033 Tbata
thymus, brain and testes associated
chr14_+_55555300 4.791 NM_026066
Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr9_-_61970402 4.777 Glce
glucuronyl C5-epimerase
chr6_-_23789259 4.444 NM_153163
Cadps2
Ca2+-dependent activator protein for secretion 2
chr6_-_85283412 4.193 NM_178639
Sfxn5
sideroflexin 5
chr2_+_158492854 4.179 NM_001159662
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr6_+_113232319 4.167 Cpne9
copine family member IX
chr11_+_61298923 4.132 NM_029568
Mfap4
microfibrillar-associated protein 4
chr4_-_134260127 4.054 NM_207237
Man1c1
mannosidase, alpha, class 1C, member 1
chr2_-_122436933 3.985 NM_025961
Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr7_+_129432810 3.982 Prkcb
protein kinase C, beta
chr11_+_98209978 3.836 NM_144828
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr13_+_54472806 3.711 Cplx2
complexin 2
chr12_+_78340039 3.683 Fut8
fucosyltransferase 8
chr14_+_34736772 3.668 NM_145741
Gdf10
growth differentiation factor 10
chr14_+_34736806 3.587 Gdf10
growth differentiation factor 10
chr9_-_65427840 3.521 NM_153119
Plekho2
pleckstrin homology domain containing, family O member 2
chr9_+_27598853 3.295 NM_177906
Opcml
opioid binding protein/cell adhesion molecule-like
chr13_+_54472705 3.226 NM_009946
Cplx2
complexin 2
chr15_+_40486577 3.175 NM_011766
Zfpm2
zinc finger protein, multitype 2
chr4_+_104829963 3.152 Ppap2b
phosphatidic acid phosphatase type 2B
chr9_+_64233432 3.135 NM_001134399
NM_172522
Megf11

multiple EGF-like-domains 11

chr5_-_108978950 3.134 NM_007756
Cplx1
complexin 1
chrX_+_147778717 3.124 NM_198105
Fam120c
family with sequence similarity 120, member C
chr10_+_81038028 3.045 NM_019725
Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr12_-_76836549 3.021 NM_030750
Sgpp1
sphingosine-1-phosphate phosphatase 1
chr7_-_31836457 2.976 NM_022007
Fxyd7
FXYD domain-containing ion transport regulator 7
chr2_-_147011990 2.947 NM_001077632
NM_010919
Nkx2-2

NK2 transcription factor related, locus 2 (Drosophila)

chr2_+_121115337 2.905 NM_032393
Mtap1a
microtubule-associated protein 1 A
chr2_-_4985090 2.900 Optn
optineurin
chr2_-_181406313 2.832 NM_009236
Sox18
SRY-box containing gene 18
chr13_+_109906361 2.823 Pde4d
phosphodiesterase 4D, cAMP specific
chr8_+_128519295 2.820 Kcnk1
potassium channel, subfamily K, member 1
chr6_+_125165597 2.812 NM_001080557
NM_009496
Vamp1

vesicle-associated membrane protein 1

chr16_-_37384915 2.720 Stxbp5l
syntaxin binding protein 5-like
chr11_+_16951911 2.713 NM_029861
Cnrip1
cannabinoid receptor interacting protein 1
chr13_+_54472833 2.689 Cplx2
complexin 2
chr8_+_128519001 2.647 NM_008430
Kcnk1
potassium channel, subfamily K, member 1
chr6_+_88674697 2.643 NM_001166250
NM_001166251
Mgll

monoglyceride lipase

chr11_-_95448869 2.638 NM_033217
Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr9_-_54509453 2.621 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr5_+_98683202 2.605 NM_010203
Fgf5
fibroblast growth factor 5
chr3_-_80717517 2.571 NM_010298
Glrb
glycine receptor, beta subunit
chr10_-_120913138 2.538 NM_138956
Rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr1_-_166388431 2.518 NM_009721
Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr10_+_128370814 2.491 NM_008398
Itga7
integrin alpha 7
chr5_-_9725274 2.481 NM_181850
Grm3
glutamate receptor, metabotropic 3
chr2_-_25174662 2.431 NM_001177656
NM_001177657
NM_008169
Grin1


glutamate receptor, ionotropic, NMDA1 (zeta 1)


chr2_+_146047656 2.430 NM_016889
Insm1
insulinoma-associated 1
chr14_-_103381744 2.397 NM_177715
Kctd12
potassium channel tetramerisation domain containing 12
chr2_-_4984983 2.359 NM_181848
Optn
optineurin
chr6_-_115201866 2.358 NM_080639
Timp4
tissue inhibitor of metalloproteinase 4
chr6_+_117118552 2.345 NM_001012477
NM_013655
NM_021704
Cxcl12


chemokine (C-X-C motif) ligand 12


chr4_-_57003214 2.343 NM_001142965
6430704M03Rik
RIKEN cDNA 6430704M03 gene
chr4_+_137220675 2.313 Rap1gap
Rap1 GTPase-activating protein
chr4_+_104829951 2.266 NM_080555
Ppap2b
phosphatidic acid phosphatase type 2B
chr2_-_30997447 2.244 Fnbp1
formin binding protein 1
chr7_+_138079669 2.238 NM_019564
Htra1
HtrA serine peptidase 1
chr8_+_10153910 2.153 NM_001081397
Myo16
myosin XVI
chr19_+_4510471 2.141 NM_001162946
Pcx
pyruvate carboxylase
chr13_+_19040215 2.140 NM_175007
Amph
amphiphysin
chr1_-_137064124 2.121 NM_134438
Gpr37l1
G protein-coupled receptor 37-like 1
chr8_+_59934719 2.080 NM_009136
Scrg1
scrapie responsive gene 1
chr11_+_68901989 2.071 Vamp2
vesicle-associated membrane protein 2
chr10_+_4795860 2.066 Syne1
synaptic nuclear envelope 1
chr2_-_77654669 2.064 NM_178723
Zfp385b
zinc finger protein 385B
chr11_+_54911540 2.045 NM_010299
Gm2a
GM2 ganglioside activator protein
chr8_-_89996474 2.043 NM_019626
Cbln1
cerebellin 1 precursor protein
chr13_+_41345120 2.012 NM_001135577
BC024659
cDNA sequence BC024659
chr12_+_78339999 2.005 NM_016893
Fut8
fucosyltransferase 8
chr19_-_40588219 1.990 NM_178362
Sorbs1
sorbin and SH3 domain containing 1
chr9_+_111214242 1.971 NM_001164659
Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
chr11_+_68902025 1.947 NM_009497
Vamp2
vesicle-associated membrane protein 2
chr1_+_91351435 1.917 Agap1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr5_-_74038829 1.902 NM_011890
Sgcb
sarcoglycan, beta (dystrophin-associated glycoprotein)
chr18_+_32536882 1.873 Bin1
bridging integrator 1
chr3_-_101408495 1.867 NM_144900
Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr5_+_37633317 1.867 NM_001136058
Crmp1
collapsin response mediator protein 1
chr2_-_117168600 1.849 NM_011246
Rasgrp1
RAS guanyl releasing protein 1
chr9_-_58160966 1.833 NM_010729
Loxl1
lysyl oxidase-like 1
chr10_+_3134318 1.830 Cnksr3
Cnksr family member 3
chr8_-_11312729 1.812 NM_009931
Col4a1
collagen, type IV, alpha 1
chr7_+_150238626 1.808 NM_133655
Cd81
CD81 antigen
chr10_+_128346900 1.763 NM_007653
Cd63
CD63 antigen
chr3_-_80606500 1.757 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr2_+_83564607 1.748 Itgav
integrin alpha V
chr4_-_154772070 1.717 NM_008072
Gabrd
gamma-aminobutyric acid (GABA) A receptor, subunit delta
chr6_+_88674821 1.700 Mgll
monoglyceride lipase
chr5_-_9725158 1.699 Grm3
glutamate receptor, metabotropic 3
chr9_-_44607274 1.674 NM_027865
Tmem25
transmembrane protein 25
chr6_-_125444722 1.670 NM_007657
Cd9
CD9 antigen
chr8_+_89996742 1.661 Gm2694
predicted gene 2694
chr2_+_118605431 1.641 NM_170593
Disp2
dispatched homolog 2 (Drosophila)
chr18_+_32536846 1.639 NM_001083334
NM_009668
Bin1

bridging integrator 1

chr12_-_113146259 1.627 NM_011625
Ppp1r13b
protein phosphatase 1, regulatory (inhibitor) subunit 13B
chr2_-_35192443 1.623 NM_013515
Stom
stomatin
chr5_+_118292144 1.606 Nos1
nitric oxide synthase 1, neuronal
chr9_-_56483379 1.594 Lingo1
leucine rich repeat and Ig domain containing 1
chr14_-_31981780 1.589 Stab1
stabilin 1
chr3_+_90345082 1.579 NM_026416
S100a16
S100 calcium binding protein A16
chr9_+_27598531 1.577 Opcml
opioid binding protein/cell adhesion molecule-like
chr2_-_93797176 1.577 NM_001145034
Gm13889
predicted gene 13889
chr18_+_66033139 1.567 NM_175012
Grp
gastrin releasing peptide
chr7_-_20282950 1.560 Apoe
apolipoprotein E
chr8_-_108467294 1.553 NM_008490
Lcat
lecithin cholesterol acyltransferase
chr8_+_97056910 1.550 NM_153507
Cpne2
copine II
chr11_-_116515602 1.543 NM_030206
Cygb
cytoglobin
chr3_-_18143265 1.543 NM_007825
Cyp7b1
cytochrome P450, family 7, subfamily b, polypeptide 1
chr4_+_3605207 1.542 NM_001111096
NM_010747
Lyn

Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

chr17_+_70318707 1.532 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr7_-_142907978 1.526 Mki67
antigen identified by monoclonal antibody Ki 67
chr7_+_17529961 1.507 NM_001099636
Pnmal2
PNMA-like 2
chr12_+_16660521 1.495 Ntsr2
neurotensin receptor 2
chr12_-_103057259 1.493 NM_011812
Fbln5
fibulin 5
chr3_+_27081918 1.490 NM_178772
Nceh1
arylacetamide deacetylase-like 1
chr11_-_3763899 1.488 NM_152818
Osbp2
oxysterol binding protein 2
chr19_-_40588193 1.481 Sorbs1
sorbin and SH3 domain containing 1
chr1_-_136131399 1.476 Adora1
adenosine A1 receptor
chr5_+_27588462 1.476 NM_001136060
Dpp6
dipeptidylpeptidase 6
chr1_+_185858324 1.475 NM_022019
Dusp10
dual specificity phosphatase 10
chr9_-_52487410 1.475 NM_178906
AI593442
expressed sequence AI593442
chr6_-_115201846 1.471 Timp4
tissue inhibitor of metalloproteinase 4
chr13_+_38436987 1.442 Bmp6
bone morphogenetic protein 6
chr5_-_64360058 1.425 NM_145923
Rell1
RELT-like 1
chr1_-_133421746 1.423 Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr18_+_58038278 1.401 NM_009194
Slc12a2
solute carrier family 12, member 2
chr6_-_124867732 1.400


chr16_-_37385024 1.391 NM_001114611
NM_001114612
NM_001114613
NM_172440
Stxbp5l



syntaxin binding protein 5-like



chr10_-_7383345 1.367 NM_008786
Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chrX_+_133200982 1.350 Tceal3
transcription elongation factor A (SII)-like 3
chr15_+_97614772 1.347 NM_026353
Slc48a1
solute carrier family 48 (heme transporter), member 1
chr15_+_51871652 1.347 NM_175503
Aard
alanine and arginine rich domain containing protein
chr5_+_113919352 1.346 NM_177292
Wscd2
WSC domain containing 2
chr10_+_59569206 1.346 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr19_+_4855178 1.345 Ctsf
cathepsin F
chr11_-_64976408 1.345 NM_001099288
NM_175003
Arhgap44

Rho GTPase activating protein 44

chr10_+_11063201 1.338 NM_010146
Epm2a
epilepsy, progressive myoclonic epilepsy, type 2 gene alpha
chr4_-_136448748 1.331 NM_007574
C1qc
complement component 1, q subcomponent, C chain
chr17_+_43153516 1.328 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr11_+_67466129 1.320 Gas7
growth arrest specific 7
chr9_-_95307645 1.313 NM_018763
Chst2
carbohydrate sulfotransferase 2
chr18_+_67247984 1.308 NM_177137
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr18_+_82723920 1.306 Mbp
myelin basic protein
chr10_+_23943322 1.298 NM_021509
Moxd1
monooxygenase, DBH-like 1
chr9_-_75459046 1.288 Tmod2
tropomodulin 2
chr1_-_89406861 1.284 NM_019867
Ngef
neuronal guanine nucleotide exchange factor
chr7_+_53651811 1.273 NM_008421
NM_001112739
Kcnc1

potassium voltage gated channel, Shaw-related subfamily, member 1

chr9_+_53192102 1.267 NM_212445
Kdelc2
KDEL (Lys-Asp-Glu-Leu) containing 2
chr8_-_114255972 1.262 NM_001198839
Bcar1
breast cancer anti-estrogen resistance 1
chr8_-_67171805 1.259 NM_013494
Cpe
carboxypeptidase E
chr11_-_7113899 1.235 NM_008343
Igfbp3
insulin-like growth factor binding protein 3
chr2_-_164268672 1.224 NM_011521
Sdc4
syndecan 4
chr2_+_33071451 1.222 NM_011923
Angptl2
angiopoietin-like 2
chr3_-_9610062 1.222 NM_133218
Zfp704
zinc finger protein 704
chr5_-_35448316 1.214 NM_013587
Lrpap1
low density lipoprotein receptor-related protein associated protein 1
chr1_-_66909822 1.204 NM_007381
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
chr2_-_7002287 1.204 Celf2
CUGBP, Elav-like family member 2
chr10_-_80893737 1.203 Nfic
nuclear factor I/C
chr15_+_6336747 1.187 NM_001037905
NM_001102400
NM_023118
Dab2


disabled homolog 2 (Drosophila)


chr7_+_96780900 1.174 Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr17_+_55585011 1.163 NM_172829
St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr10_+_3134299 1.160 NM_172546
Cnksr3
Cnksr family member 3
chr19_-_40588235 1.157 Sorbs1
sorbin and SH3 domain containing 1
chr16_+_49855691 1.144 NM_010581
Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr9_+_43851466 1.134 NM_009382
Thy1
thymus cell antigen 1, theta
chr18_+_82753560 1.129 Mbp
myelin basic protein
chr2_+_59450123 1.128


chr3_+_122970332 1.126 NM_027135
Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr17_-_48061354 1.123 Foxp4
forkhead box P4
chr6_-_23789419 1.118 Cadps2
Ca2+-dependent activator protein for secretion 2
chr17_-_50329593 1.116 NM_181397
Rftn1
raftlin lipid raft linker 1
chr2_+_124436328 1.115 Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr7_+_96781228 1.113 Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr18_+_32536898 1.113 Bin1
bridging integrator 1
chr19_-_40588255 1.108 Sorbs1
sorbin and SH3 domain containing 1
chr3_-_55987612 1.106 NM_030595
Nbea
neurobeachin
chr4_-_135429750 1.105 NM_026383
Pnrc2
proline-rich nuclear receptor coactivator 2
chr15_+_78744328 1.101 NM_020271
Pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr4_-_106136704 1.101 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr11_-_109472695 1.093 NM_145940
Wipi1
WD repeat domain, phosphoinositide interacting 1
chr2_+_32502186 1.091 Eng
endoglin
chr8_+_89996675 1.091 Gm2694
predicted gene 2694
chr3_-_80717578 1.083 Glrb
glycine receptor, beta subunit
chr7_-_36340918 1.083 NM_033080
Nudt19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr10_+_115738429 1.082 NM_029928
Ptprb
protein tyrosine phosphatase, receptor type, B
chr7_-_7251473 1.076 Clcn4-2
chloride channel 4-2
chr10_+_81037993 1.073 Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr10_+_4795808 1.071 NM_153399
Syne1
synaptic nuclear envelope 1
chr17_+_29627697 1.069 Pim1
proviral integration site 1
chr10_+_93977597 1.055 NM_172051
Tmcc3
transmembrane and coiled coil domains 3
chr11_+_87391881 1.049 Sept4
septin 4
chr9_+_75473524 1.046 NM_027309
Lysmd2
LysM, putative peptidoglycan-binding, domain containing 2
chr17_+_35068258 1.045 Neu1
neuraminidase 1
chr15_+_74786009 1.034 Ly6e
lymphocyte antigen 6 complex, locus E
chr19_+_8665743 1.027 NM_001164634
NM_031194
Slc22a8

solute carrier family 22 (organic anion transporter), member 8


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
6.09 2.97e-06 GO:0019226 transmission of nerve impulse
6.09 2.97e-06 GO:0035637 multicellular organismal signaling
2.18 4.58e-06 GO:0051179 localization
6.78 6.11e-06 GO:0007268 synaptic transmission
4.97 5.82e-05 GO:0007267 cell-cell signaling
3.96 7.58e-05 GO:0007154 cell communication
4.03 1.19e-04 GO:0016192 vesicle-mediated transport
2.77 1.21e-04 GO:0023051 regulation of signaling
2.64 1.43e-04 GO:0048583 regulation of response to stimulus
2.16 1.56e-04 GO:0051234 establishment of localization
2.15 2.56e-04 GO:0006810 transport
2.81 9.70e-04 GO:0009966 regulation of signal transduction
2.29 4.94e-03 GO:0065008 regulation of biological quality
3.13 1.04e-02 GO:0051049 regulation of transport
4.26 1.18e-02 GO:0051050 positive regulation of transport
2.99 1.19e-02 GO:0051128 regulation of cellular component organization
11.47 1.29e-02 GO:0045807 positive regulation of endocytosis
2.65 2.72e-02 GO:0032879 regulation of localization
13.89 2.73e-02 GO:0048489 synaptic vesicle transport
1.88 3.11e-02 GO:0048518 positive regulation of biological process
1.90 3.15e-02 GO:0048856 anatomical structure development
1.96 3.18e-02 GO:0048731 system development
1.94 3.20e-02 GO:0048522 positive regulation of cellular process
1.58 3.31e-02 GO:0032501 multicellular organismal process
20.28 3.88e-02 GO:0016079 synaptic vesicle exocytosis
4.88 3.95e-02 GO:0048514 blood vessel morphogenesis
4.41 4.12e-02 GO:0001568 blood vessel development
2.55 4.84e-02 GO:0010646 regulation of cell communication

Gene overrepresentation in compartment category:

enrichment p-value GO term description
5.38 2.35e-08 GO:0045202 synapse
2.14 4.24e-08 GO:0071944 cell periphery
2.12 1.48e-07 GO:0005886 plasma membrane
2.64 2.50e-06 GO:0044459 plasma membrane part
5.61 5.08e-06 GO:0044456 synapse part
7.97 2.47e-05 GO:0045211 postsynaptic membrane
4.00 5.23e-05 GO:0043005 neuron projection
1.49 7.03e-05 GO:0016020 membrane
2.78 5.93e-04 GO:0042995 cell projection
1.44 8.96e-04 GO:0005737 cytoplasm
3.17 9.07e-04 GO:0031982 vesicle
1.58 1.58e-03 GO:0044444 cytoplasmic part
3.99 2.11e-03 GO:0044463 cell projection part
2.78 2.40e-03 GO:0044421 extracellular region part
7.07 3.17e-03 GO:0033267 axon part
4.51 6.21e-03 GO:0030425 dendrite
3.05 7.80e-03 GO:0031226 intrinsic to plasma membrane
8.97 9.67e-03 GO:0043679 axon terminus
3.04 1.38e-02 GO:0005887 integral to plasma membrane
4.49 1.46e-02 GO:0030424 axon
8.33 1.47e-02 GO:0044306 neuron projection terminus
2.87 1.68e-02 GO:0031410 cytoplasmic vesicle
2.36 1.91e-02 GO:0000267 cell fraction
2.61 2.25e-02 GO:0005624 membrane fraction
15.05 2.38e-02 GO:0044304 main axon
3.09 3.34e-02 GO:0031988 membrane-bounded vesicle
1.41 3.61e-02 GO:0044425 membrane part
24.99 3.67e-02 GO:0048786 presynaptic active zone
4.97 3.83e-02 GO:0045121 membrane raft
2.49 4.05e-02 GO:0005626 insoluble fraction
2.87 4.27e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment p-value GO term description
1.84 4.53e-08 GO:0005515 protein binding
3.09 6.57e-05 GO:0005102 receptor binding
116.59 1.41e-04 GO:0070326 very-low-density lipoprotein particle receptor binding
1.34 7.33e-04 GO:0005488 binding
4.29 2.65e-03 GO:0032403 protein complex binding
2.59 3.22e-02 GO:0022892 substrate-specific transporter activity
2.88 3.40e-02 GO:0015075 ion transmembrane transporter activity
3.53 3.72e-02 GO:0008289 lipid binding
26.91 3.79e-02 GO:0017075 syntaxin-1 binding
2.41 3.79e-02 GO:0005215 transporter activity
77.73 4.99e-02 GO:0004865 protein serine/threonine phosphatase inhibitor activity
77.73 4.99e-02 GO:0070053 thrombospondin receptor activity