• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: TFEB.p2

Z-value: 1.205

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Top targets:

Promoter	Score	Refseq	Gene	Description
chr2_+_164659268	7.520		Ctsa	cathepsin A
chr14_+_70857227	6.532	NM_145981	Phyhip	phytanoyl-CoA hydroxylase interacting protein
chr2_-_79296732	5.460	NM_010894	Neurod1	neurogenic differentiation 1
chr5_+_137506122	4.698	NM_001039385	Vgf	VGF nerve growth factor inducible
chr16_+_45158943	4.581		Atg3	autophagy-related 3 (yeast)
chr11_-_70053281	4.386	NM_173742	Rnasek	ribonuclease, RNase K
chr8_+_13159112	4.384	NM_010684	Lamp1	lysosomal-associated membrane protein 1
chr11_+_29618696	4.285		Rtn4	reticulon 4
chrX_+_133200982	4.271		Tceal3	transcription elongation factor A (SII)-like 3
chr10_+_128346900	4.203	NM_007653	Cd63	CD63 antigen
chr4_+_129985957	4.132	NM_010174	Fabp3	fatty acid binding protein 3, muscle and heart
chr8_+_13159279	4.019		Lamp1	lysosomal-associated membrane protein 1
chr6_+_116288075	4.009	NM_027920	March8	membrane-associated ring finger (C3HC4) 8
chr18_+_12327237	3.984	NM_029623	3110002H16Rik	RIKEN cDNA 3110002H16 gene
chr9_-_91260619	3.956	NM_009573	Zic1	zinc finger protein of the cerebellum 1
chr7_-_20284370	3.872		Apoe	apolipoprotein E
chr15_+_66409094	3.723	NM_001081409	Phf20l1	PHD finger protein 20-like 1
chr4_+_137220675	3.660		Rap1gap	Rap1 GTPase-activating protein
chr19_+_23215704	3.638	NM_010638	Klf9	Kruppel-like factor 9
chr15_-_78236262	3.625	NM_009437	Tst	thiosulfate sulfurtransferase, mitochondrial
chr8_-_89996474	3.404	NM_019626	Cbln1	cerebellin 1 precursor protein
chr3_+_104442568	3.196	NM_009196	Slc16a1	solute carrier family 16 (monocarboxylic acid transporters), member 1
chr14_+_63741339	3.189		Ctsb	cathepsin B
chr9_-_91260597	3.157		Zic1	zinc finger protein of the cerebellum 1
chrX_+_131135770	3.110	NM_019868	Hnrnph2	heterogeneous nuclear ribonucleoprotein H2
chr16_-_44139087	3.044	NM_007508	Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A
chr7_+_108496574	2.962	NM_001040111	Arap1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr4_+_84851330	2.872	NM_019535	Sh3gl2	SH3-domain GRB2-like 2
chr11_-_98190774	2.803	NM_010895	Neurod2	neurogenic differentiation 2
chr10_+_122115755	2.710	NM_001110218 NM_176919	Ppm1h	protein phosphatase 1H (PP2C domain containing)
chr3_+_138190223	2.651		Eif4e	eukaryotic translation initiation factor 4E
chr9_+_89804723	2.598		Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1
chr7_-_149573693	2.592	NM_009983	Ctsd	cathepsin D
chr11_-_116060026	2.571		Acox1	acyl-Coenzyme A oxidase 1, palmitoyl
chr6_+_116287992	2.548		March8	membrane-associated ring finger (C3HC4) 8
chr1_+_6720153	2.548		St18	suppression of tumorigenicity 18
chr11_-_115948206	2.546		Wbp2	WW domain binding protein 2
chr11_-_115948258	2.456	NM_016852	Wbp2	WW domain binding protein 2
chr6_+_54222814	2.451	NM_023543	Chn2	chimerin (chimaerin) 2
chr6_-_108135548	2.442	NM_145937	Sumf1	sulfatase modifying factor 1
chr17_+_25270317	2.362	NM_011930	Clcn7	chloride channel 7
chr3_+_89006824	2.331	NM_001077411 NM_008094	Gba	glucosidase, beta, acid
chr3_-_87804062	2.325		Bcan	brevican
chr11_+_119129350	2.278		Gaa	glucosidase, alpha, acid
chr8_+_3500470	2.236	NM_053177	Mcoln1	mucolipin 1
chrX_+_149574498	2.233	NM_001004154	Rragb	Ras-related GTP binding B
chr11_+_55017825	2.197	NM_153139	Slc36a1	solute carrier family 36 (proton/amino acid symporter), member 1
chr2_-_30141839	2.165	NM_177648	Dolk	dolichol kinase
chr6_+_108610606	2.157	NM_011498	Bhlhe40	basic helix-loop-helix family, member e40
chr17_-_27076365	2.129	NM_026307 NM_026948	Cuta	cutA divalent cation tolerance homolog (E. coli)
chr6_+_134879160	2.095		1190002F15Rik	RIKEN cDNA 1190002F15 gene
chr19_+_23215725	2.076		Klf9	Kruppel-like factor 9
chr2_-_25211822	2.073	NM_031843	Dpp7	dipeptidylpeptidase 7
chr11_+_54251680	2.072	NM_173753	Fnip1	folliculin interacting protein 1
chr9_+_58430031	2.067	NM_009145	Nptn	neuroplastin
chr9_-_70504934	2.058	NM_172772	Fam63b	family with sequence similarity 63, member B
chr11_-_73012493	2.044	NM_031251	Ctns	cystinosis, nephropathic
chr6_+_134870418	2.043	NM_009875	Cdkn1b	cyclin-dependent kinase inhibitor 1B
chr9_-_83699706	2.023	NM_001145974 NM_148941	Elovl4	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr6_+_116158049	2.021	NM_026585	D6Wsu116e	DNA segment, Chr 6, Wayne State University 116, expressed
chr7_+_16683891	2.004	NM_025898	Napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha
chr15_+_34167908	1.982		Laptm4b	lysosomal-associated protein transmembrane 4B
chr17_-_27075896	1.979		Cuta	cutA divalent cation tolerance homolog (E. coli)
chr7_-_104566013	1.959	NM_009381	Thrsp	thyroid hormone responsive SPOT14 homolog (Rattus)
chr4_+_123594712	1.947		Rragc	Ras-related GTP binding C
chr10_-_94879369	1.943		Socs2	suppressor of cytokine signaling 2
chr5_-_124482223	1.928	NM_177876	Vps37b	vacuolar protein sorting 37B (yeast)
chr4_-_117559857	1.927	NM_033617	Atp6v0b	ATPase, H+ transporting, lysosomal V0 subunit B
chr11_+_60591019	1.926	NM_001085440 NM_175491	Smcr8	Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
chr1_+_6720087	1.921	NM_173868	St18	suppression of tumorigenicity 18
chr8_-_108089811	1.907	NM_013477	Atp6v0d1	ATPase, H+ transporting, lysosomal V0 subunit D1
chr7_-_112900699	1.860	NM_009906	Tpp1	tripeptidyl peptidase I
chr1_-_136131399	1.856		Adora1	adenosine A1 receptor
chr17_-_56615784	1.852		Ptprs	protein tyrosine phosphatase, receptor type, S
chr17_-_56615861	1.803		Ptprs	protein tyrosine phosphatase, receptor type, S
chr15_-_3945704	1.796	NM_145930	AW549877	expressed sequence AW549877
chr17_+_26813327	1.767	NM_025272	Atp6v0e	ATPase, H+ transporting, lysosomal V0 subunit E
chrX_+_71542444	1.758		Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1
chr11_+_102622885	1.754		Adam11	a disintegrin and metallopeptidase domain 11
chr6_+_134870680	1.717		Cdkn1b	cyclin-dependent kinase inhibitor 1B
chr1_-_177422630	1.716	NM_001199003 NM_011880	Rgs7	regulator of G protein signaling 7
chr9_+_20673069	1.686	NM_175687	A230050P20Rik	RIKEN cDNA A230050P20 gene
chr9_+_58430210	1.671		Nptn	neuroplastin
chr12_+_3426883	1.609	NM_172421	Asxl2	additional sex combs like 2 (Drosophila)
chr7_-_90883999	1.606	NM_010551	Il16	interleukin 16
chr5_-_115223373	1.598	NM_001077360 NM_019834 NM_001077359	Git2	G protein-coupled receptor kinase-interactor 2
chr15_+_82105647	1.591		Sept3	septin 3
chr12_-_103196366	1.583	NM_001167914 NM_029705	Atxn3	ataxin 3
chr3_-_9833502	1.580	NM_001195031 NM_053182	Pag1	phosphoprotein associated with glycosphingolipid microdomains 1
chr4_+_34011567	1.572	NM_007726	Cnr1	cannabinoid receptor 1 (brain)
chr12_-_87165448	1.554	NM_021446	0610007P14Rik	RIKEN cDNA 0610007P14 gene
chr10_+_13220833	1.550	NM_025799	Fuca2	fucosidase, alpha-L- 2, plasma
chr9_-_86775282	1.548		Snap91	synaptosomal-associated protein 91
chr4_-_45097427	1.545	NM_001024142	Fbxo10	F-box protein 10
chr1_+_139795165	1.542		A630083H20Rik	RIKEN cDNA A630083H20 gene
chr5_-_100467887	1.526		Hnrpdl	heterogeneous nuclear ribonucleoprotein D-like
chr16_-_45158709	1.510	NM_028756	Slc35a5	solute carrier family 35, member A5
chr9_+_70526702	1.502	NM_007399	Adam10	a disintegrin and metallopeptidase domain 10
chr1_+_167693876	1.500	NM_011804	Creg1	cellular repressor of E1A-stimulated genes 1
chr8_+_113245378	1.489	NM_198625	Mtss1l	metastasis suppressor 1-like
chr3_+_89577436	1.488	NM_027315	Ube2q1	ubiquitin-conjugating enzyme E2Q (putative) 1
chr13_-_64471609	1.482	NM_009984	Ctsl	cathepsin L
chr9_-_53475591	1.481		Cul5	cullin 5
chr11_-_54846882	1.464	NM_001110211 NM_013472	Anxa6	annexin A6
chr1_-_30930715	1.455		Phf3	PHD finger protein 3
chr11_+_69814046	1.453	NM_007888	Dvl2	dishevelled 2, dsh homolog (Drosophila)
chr2_-_152777135	1.453	NM_145744 NM_001159376	Dusp15	dual specificity phosphatase-like 15
chr15_+_100446018	1.450	NM_011873	Dazap2	DAZ associated protein 2
chr16_+_45158927	1.428	NM_026402	Atg3	autophagy-related 3 (yeast)
chr3_-_108029499	1.423	NM_008596	Sypl2	synaptophysin-like 2
chr11_-_94902584	1.423	NM_133667	Pdk2	pyruvate dehydrogenase kinase, isoenzyme 2
chr5_+_115461102	1.409		Sppl3	signal peptide peptidase 3
chr7_+_134913327	1.401	NM_198424	Orai3	ORAI calcium release-activated calcium modulator 3
chr3_+_96531494	1.389	NM_026406	Rnf115	ring finger protein 115
chr7_-_117103903	1.374	NM_021494	Dennd5a	DENN/MADD domain containing 5A
chr9_+_45820886	1.373	NM_027498	Sik3	SIK family kinase 3
chr15_+_101904294	1.366		Eif4b	eukaryotic translation initiation factor 4B
chr4_-_147412919	1.353		Clcn6	chloride channel 6
chr19_-_7062118	1.350	NM_001185164 NM_011697	Vegfb	vascular endothelial growth factor B
chr2_+_92755251	1.339	NM_030725	Syt13	synaptotagmin XIII
chr2_+_90687308	1.335	NM_019758	Mtch2	mitochondrial carrier homolog 2 (C. elegans)
chr17_+_35068258	1.335		Neu1	neuraminidase 1
chr8_+_122638031	1.322	NM_001163761 NM_001163762 NM_172286	6430548M08Rik	RIKEN cDNA 6430548M08 gene
chr5_-_151397024	1.316	NM_133898	N4bp2l1	NEDD4 binding protein 2-like 1
chr4_-_141346551	1.314	NM_172338	Dnajc16	DnaJ (Hsp40) homolog, subfamily C, member 16
chr13_-_76081142	1.312		Rhobtb3	Rho-related BTB domain containing 3
chr10_-_62801726	1.311	NM_001159590 NM_019812 NM_001159589	Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
chr9_-_53475563	1.306		Cul5	cullin 5
chr12_+_88288287	1.305	NM_173735	2310044G17Rik	RIKEN cDNA 2310044G17 gene
chr2_+_71291369	1.304	NM_025633	Metap1d	methionyl aminopeptidase type 1D (mitochondrial)
chr1_-_55084269	1.299		Sf3b1	splicing factor 3b, subunit 1
chr2_+_18594027	1.296	NM_147778	Commd3	COMM domain containing 3
chr6_-_58857000	1.293	NM_021432	Nap1l5	nucleosome assembly protein 1-like 5
chr9_-_86775154	1.292	NM_013669	Snap91	synaptosomal-associated protein 91
chr7_-_52722144	1.290	NM_007527	Bax	BCL2-associated X protein
chr4_-_147412872	1.285	NM_011929	Clcn6	chloride channel 6
chr8_-_89996089	1.269		Cbln1	cerebellin 1 precursor protein
chr7_-_133520899	1.262		Spns1	spinster homolog 1 (Drosophila)
chr5_+_30950295	1.259	NM_175675	4930471M23Rik	RIKEN cDNA 4930471M23 gene
chr7_-_54051250	1.247	NM_001005247 NM_001005248 NM_001167864	Hps5	Hermansky-Pudlak syndrome 5 homolog (human)
chr17_-_90487479	1.242		Nrxn1	neurexin I
chr8_-_108224931	1.234		Acd	adrenocortical dysplasia
chr2_-_26092876	1.230	NM_153559	Qsox2	quiescin Q6 sulfhydryl oxidase 2
chrX_-_156576312	1.228		Pdha1	pyruvate dehydrogenase E1 alpha 1
chrX_+_149574541	1.226		Rragb	Ras-related GTP binding B
chr7_+_127986324	1.221	NM_007908	Eef2k	eukaryotic elongation factor-2 kinase
chr9_-_113617224	1.205	NM_001164677 NM_001164678 NM_011052	Pdcd6ip	programmed cell death 6 interacting protein
chr4_-_154273134	1.194	NM_025582	2810405K02Rik	RIKEN cDNA 2810405K02 gene
chr18_+_77303959	1.194		Pias2	protein inhibitor of activated STAT 2
chr9_-_41932371	1.188	NM_011436	Sorl1	sortilin-related receptor, LDLR class A repeats-containing
chr10_+_79167102	1.184	NM_001077184 NM_009768	Bsg	basigin
chr17_+_26852581	1.182	NM_029870	A930001N09Rik	RIKEN cDNA A930001N09 gene
chr5_+_139856534	1.166	NM_030258	Gpr146	G protein-coupled receptor 146
chr5_-_24348170	1.165	NM_053075	Rheb	Ras homolog enriched in brain
chr11_+_102291759	1.165		Grn	granulin
chr16_+_37868511	1.161		Lrrc58	leucine rich repeat containing 58
chr3_-_30868320	1.160	NM_001165954 NM_001165955 NM_001165956 NM_153421	Phc3	polyhomeotic-like 3 (Drosophila)
chr14_-_51550327	1.151	NM_001033271	Tmem55b	transmembrane protein 55b
chr17_+_53618611	1.151		Rab5a	RAB5A, member RAS oncogene family
chr10_+_122116066	1.148		Ppm1h	protein phosphatase 1H (PP2C domain containing)
chr13_+_85329102	1.144		Ccnh	cyclin H
chr15_-_93167308	1.141	NM_024189	Yaf2	YY1 associated factor 2
chr2_+_83652779	1.141		Fam171b	family with sequence similarity 171, member B
chr6_+_134879109	1.134		1190002F15Rik	RIKEN cDNA 1190002F15 gene
chr1_+_174056868	1.134	NM_001159525 NM_023041	Pex19	peroxisomal biogenesis factor 19
chr5_-_124053691	1.129		Clip1	CAP-GLY domain containing linker protein 1
chr1_-_55084217	1.114		Sf3b1	splicing factor 3b, subunit 1
chr18_+_36508277	1.113	NM_001081365	0610010O12Rik	RIKEN cDNA 0610010O12 gene
chr16_-_5049936	1.112		Glyr1	glyoxylate reductase 1 homolog (Arabidopsis)
chr6_+_90412566	1.112	NM_023184	Klf15	Kruppel-like factor 15
chr10_+_79167255	1.109		Bsg	basigin
chr17_-_25377052	1.106	NM_172529	Gnptg	N-acetylglucosamine-1-phosphotransferase, gamma subunit
chr2_-_126701791	1.103	NM_001164325 NM_021450	Trpm7	transient receptor potential cation channel, subfamily M, member 7
chr4_+_133130651	1.101	NM_172876	Gpatch3	G patch domain containing 3
chr3_-_19935292	1.100	NM_001146323 NM_001146324 NM_080634	Hps3	Hermansky-Pudlak syndrome 3 homolog (human)
chr17_-_24306262	1.099	NM_009729	Atp6v0c-ps2 Atp6v0c	ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 2 ATPase, H+ transporting, lysosomal V0 subunit C
chr8_+_113142480	1.098	NM_146216	Vac14	Vac14 homolog (S. cerevisiae)
chrX_+_12164878	1.096	NM_027439	Atp6ap2	ATPase, H+ transporting, lysosomal accessory protein 2
chr7_-_52104247	1.096		Tbc1d17	TBC1 domain family, member 17
chr2_-_5816330	1.087		Sec61a2	Sec61, alpha subunit 2 (S. cerevisiae)
chr3_-_126865105	1.085		Ank2	ankyrin 2, brain
chr17_-_26645403	1.073	NM_013642	Dusp1	dual specificity phosphatase 1
chr15_+_73578771	1.071		Ptp4a3	protein tyrosine phosphatase 4a3
chr19_-_55177562	1.071		Gpam	glycerol-3-phosphate acyltransferase, mitochondrial
chr10_+_79317316	1.069	NM_001077363 NM_008956	Ptbp1	polypyrimidine tract binding protein 1
chr19_+_21727662	1.054		Fam108b	family with sequence similarity 108, member B
chr4_+_73897782	1.053	NM_144787	Kdm4c	lysine (K)-specific demethylase 4C
chr4_+_8617613	1.038		Chd7	chromodomain helicase DNA binding protein 7
chr11_+_102050933	1.018	NM_175935	G6pc3	glucose 6 phosphatase, catalytic, 3
chr3_-_20054899	1.016		Gyg	glycogenin
chr2_-_164658954	1.015	NM_001082974	Neurl2	neuralized-like 2 (Drosophila)
chr1_-_188529867	1.012	NM_009367	Tgfb2	transforming growth factor, beta 2
chr5_-_120953567	1.011	NM_023625	Plbd2	phospholipase B domain containing 2
chr10_-_114688480	1.010	NM_025706	Tbc1d15	TBC1 domain family, member 15
chr10_+_80847168	1.005	NM_133964	Dohh	deoxyhypusine hydroxylase/monooxygenase
chr18_+_75178449	1.003		Dym	dymeclin
chrX_-_110299092	1.001	NM_018818	Chm	choroidermia
chr17_-_56615875	0.999	NM_011218	Ptprs	protein tyrosine phosphatase, receptor type, S
chr8_+_124114323	0.999	NM_026160	Map1lc3b	microtubule-associated protein 1 light chain 3 beta
chr10_-_6080145	0.996	NM_031185	Akap12	A kinase (PRKA) anchor protein (gravin) 12

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.24	8.16e-07	GO:0051179	localization
2.36	2.20e-06	GO:0006810	transport
2.33	3.86e-06	GO:0051234	establishment of localization
27.22	5.34e-05	GO:0015988	energy coupled proton transport, against electrochemical gradient
27.22	5.34e-05	GO:0015991	ATP hydrolysis coupled proton transport
23.59	1.34e-04	GO:0015682	ferric iron transport
23.59	1.34e-04	GO:0033572	transferrin transport
2.84	6.86e-04	GO:0033036	macromolecule localization
13.32	7.22e-04	GO:0015992	proton transport
13.11	8.07e-04	GO:0006818	hydrogen transport
15.39	1.89e-03	GO:0007033	vacuole organization
1.54	3.04e-03	GO:0044238	primary metabolic process
2.86	4.38e-03	GO:0008104	protein localization
13.11	4.92e-03	GO:0006826	iron ion transport
3.04	1.31e-02	GO:0015031	protein transport
2.71	1.64e-02	GO:0051641	cellular localization
2.97	1.79e-02	GO:0045184	establishment of protein localization

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
10.50	2.18e-16	GO:0005773	vacuole
9.96	2.03e-12	GO:0000323	lytic vacuole
9.96	2.03e-12	GO:0005764	lysosome
2.05	3.42e-12	GO:0044444	cytoplasmic part
1.59	2.29e-07	GO:0005737	cytoplasm
1.43	2.29e-07	GO:0005622	intracellular
5.23	6.76e-07	GO:0005768	endosome
37.25	1.31e-06	GO:0033176	proton-transporting V-type ATPase complex
1.42	2.14e-06	GO:0044424	intracellular part
1.52	1.02e-05	GO:0043231	intracellular membrane-bounded organelle
1.52	1.14e-05	GO:0043227	membrane-bounded organelle
78.63	1.16e-05	GO:0033179	proton-transporting V-type ATPase, V0 domain
9.93	4.97e-05	GO:0010008	endosome membrane
9.93	4.97e-05	GO:0044440	endosomal part
19.13	9.93e-05	GO:0016469	proton-transporting two-sector ATPase complex
1.43	1.03e-04	GO:0043229	intracellular organelle
1.43	1.21e-04	GO:0043226	organelle
2.65	7.91e-04	GO:0031090	organelle membrane
29.49	1.32e-03	GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
14.75	3.36e-03	GO:0042734	presynaptic membrane
10.41	3.77e-03	GO:0005774	vacuolar membrane
9.70	5.66e-03	GO:0044437	vacuolar part
1.18	6.70e-03	GO:0005623	cell
1.18	6.70e-03	GO:0044464	cell part
8.53	1.17e-02	GO:0005770	late endosome
2.90	1.32e-02	GO:0031410	cytoplasmic vesicle
3.29	1.53e-02	GO:0016023	cytoplasmic membrane-bounded vesicle
29.49	1.97e-02	GO:0016471	vacuolar proton-transporting V-type ATPase complex
3.12	2.69e-02	GO:0031988	membrane-bounded vesicle
2.73	2.77e-02	GO:0031982	vesicle

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.69	3.08e-05	GO:0005515	protein binding
10.59	8.35e-04	GO:0015078	hydrogen ion transmembrane transporter activity
4.63	2.28e-03	GO:0022804	active transmembrane transporter activity
2.02	5.82e-03	GO:0016787	hydrolase activity
1.28	1.68e-02	GO:0005488	binding
1.51	3.33e-02	GO:0003824	catalytic activity
9.52	3.44e-02	GO:0042625	ATPase activity, coupled to transmembrane movement of ions
7.23	3.56e-02	GO:0015399	primary active transmembrane transporter activity
7.23	3.56e-02	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity
25.28	3.91e-02	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
78.63	4.11e-02	GO:0030984	kininogen binding
5.62	4.95e-02	GO:0015077	monovalent inorganic cation transmembrane transporter activity