Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 2.383

Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

NameEntrezDescription
Tlx1 21908 T-cell leukemia, homeobox 1
Tlx3 27140 T-cell leukemia, homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Tlx1chr19_+_45225176-0.538.0e-04Click!
Tlx3chr11_-_331034580.231.7e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr2_-_25325248 52.738 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr18_+_82723920 52.555 Mbp
myelin basic protein
chr18_+_82723907 32.786 Mbp
myelin basic protein
chr2_-_170232008 25.858 Bcas1
breast carcinoma amplified sequence 1
chr11_-_98190774 24.970 NM_010895
Neurod2
neurogenic differentiation 2
chr8_-_70342105 23.635 NM_027626
Psd3
pleckstrin and Sec7 domain containing 3
chr11_-_102758340 23.483 Gfap
glial fibrillary acidic protein
chr18_+_82723854 19.738 NM_001025251
NM_001025255
NM_001025256
NM_001025258
NM_001025259
NM_001025254
Mbp





myelin basic protein





chr7_+_35971403 17.981 NM_017394
Slc7a10
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
chr6_-_115201866 15.607 NM_080639
Timp4
tissue inhibitor of metalloproteinase 4
chr6_-_85283412 15.579 NM_178639
Sfxn5
sideroflexin 5
chrX_-_45388010 15.419 NM_013912
Apln
apelin
chr11_-_116515361 14.084 Cygb
cytoglobin
chr7_-_104566013 13.717 NM_009381
Thrsp
thyroid hormone responsive SPOT14 homolog (Rattus)
chr6_-_115201846 12.777 Timp4
tissue inhibitor of metalloproteinase 4
chr15_-_78034565 12.729 NM_013645
Pvalb
parvalbumin
chr11_-_102758460 12.545 NM_001131020
NM_010277
Gfap

glial fibrillary acidic protein

chrX_+_162676910 12.440 Gpm6b
glycoprotein m6b
chr19_+_29999596 12.030 NM_133775
Il33
interleukin 33
chr9_-_60497537 10.574 Lrrc49
leucine rich repeat containing 49
chr8_+_75170609 10.372 NM_176940
Nwd1
NACHT and WD repeat domain containing 1
chr18_-_78320014 10.246 Slc14a1
solute carrier family 14 (urea transporter), member 1
chr15_-_78034648 10.179 Pvalb
parvalbumin
chr19_+_5741862 10.116 Ltbp3
latent transforming growth factor beta binding protein 3
chr1_+_174271397 10.025 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr11_-_116515602 9.994 NM_030206
Cygb
cytoglobin
chr18_-_33623287 9.840 NM_053078
D0H4S114
DNA segment, human D4S114
chr18_+_38115192 9.673 NM_153793
Rell2
RELT-like 2
chr1_-_79436564 9.586 NM_009129
Scg2
secretogranin II
chr16_-_85803343 9.147 Adamts1
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
chr9_-_53418394 9.103 NM_144784
Acat1
acetyl-Coenzyme A acetyltransferase 1
chr11_-_116515232 8.845 Cygb
cytoglobin
chr11_+_78137699 8.843 NM_009657
Aldoc
aldolase C, fructose-bisphosphate
chr18_-_33623273 8.610 D0H4S114
DNA segment, human D4S114
chr2_+_156301543 8.552 NM_001006664
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr18_-_78320126 8.494 NM_001171010
NM_028122
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr3_-_8666985 8.334 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr2_+_164311755 8.320 NM_026797
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr11_+_3388229 8.316 NM_172791
Pla2g3
phospholipase A2, group III
chr1_+_187278726 8.026 NM_001033286
Slc30a10
solute carrier family 30, member 10
chr16_-_85803359 7.539 NM_009621
Adamts1
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
chr6_+_17256415 7.124 Cav1
caveolin 1, caveolae protein
chr17_+_24607348 6.943 NM_025954
Pgp
phosphoglycolate phosphatase
chr8_+_23868194 6.907 NM_008872
Plat
plasminogen activator, tissue
chr7_-_88851662 6.836 Homer2
homer homolog 2 (Drosophila)
chr3_+_90341208 6.771 S100a16
S100 calcium binding protein A16
chr8_+_97508270 6.762 NM_018882
Gpr56
G protein-coupled receptor 56
chr2_+_32502107 6.588 NM_001146348
NM_001146350
NM_007932
Eng


endoglin


chr4_-_136512727 6.423 NM_007939
Epha8
Eph receptor A8
chr7_+_28233013 6.410 Blvrb
biliverdin reductase B (flavin reductase (NADPH))
chr2_-_25325196 6.127 Ptgds
prostaglandin D2 synthase (brain)
chr15_+_81633102 6.078 NM_153484
Tef
thyrotroph embryonic factor
chr9_-_77956353 5.833 NM_023605
Fbxo9
f-box protein 9
chr2_+_4322447 5.767 Frmd4a
FERM domain containing 4A
chr2_+_149656518 5.660 NM_001085521
Tmem90b
transmembrane protein 90B
chr6_-_24905939 5.579 NM_177013
Tmem229a
transmembrane protein 229A
chr5_-_77544147 5.306 NM_175606
Hopx
HOP homeobox
chr4_-_91038729 4.841 NM_010486
NM_207686
Elavl2

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)

chr2_+_32502186 4.790 Eng
endoglin
chr13_+_38436987 4.729 Bmp6
bone morphogenetic protein 6
chr4_+_117507914 4.717 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr3_-_117063090 4.710 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr11_-_117830455 4.703 Socs3
suppressor of cytokine signaling 3
chr5_-_9725274 4.703 NM_181850
Grm3
glutamate receptor, metabotropic 3
chr9_-_91255831 4.689 Zic1
zinc finger protein of the cerebellum 1
chr16_+_49855691 4.610 NM_010581
Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr10_-_127057998 4.602 Lrp1
low density lipoprotein receptor-related protein 1
chr4_+_62360705 4.477 Rgs3
regulator of G-protein signaling 3
chr1_-_5009431 4.416 NM_021374
Rgs20
regulator of G-protein signaling 20
chr2_-_91489909 4.287 NM_001033451
Zfp408
zinc finger protein 408
chr3_-_8666930 4.183 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr10_-_61802814 4.177 Hk1
hexokinase 1
chr3_-_8667013 4.067 NM_010423
Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr16_+_90831052 4.025 NM_027627
4931408A02Rik
RIKEN cDNA 4931408A02 gene
chr11_+_61298923 3.991 NM_029568
Mfap4
microfibrillar-associated protein 4
chr7_-_112630662 3.873 NM_028444
Prkcdbp
protein kinase C, delta binding protein
chr1_+_174271338 3.827 NM_001039484
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr7_-_133819870 3.820 NM_133670
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr11_-_75236018 3.791 Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr11_-_69734369 3.765 NM_001166592
NM_001166594
Eif5a

eukaryotic translation initiation factor 5A

chr14_-_55735399 3.753 Jph4
junctophilin 4
chr11_-_118216625 3.743 Timp2
tissue inhibitor of metalloproteinase 2
chr11_-_118263125 3.742 NM_011150
Lgals3bp
lectin, galactoside-binding, soluble, 3 binding protein
chr3_-_63768461 3.709 NM_015728
Slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr12_-_81233799 3.696 2310015A10Rik
RIKEN cDNA 2310015A10 gene
chr11_+_120094240 3.647 NM_198423
Bahcc1
BAH domain and coiled-coil containing 1
chr11_-_88921858 3.634 Dgke
diacylglycerol kinase, epsilon
chr3_-_115417685 3.599 S1pr1
sphingosine-1-phosphate receptor 1
chr6_+_17256383 3.585 Cav1
caveolin 1, caveolae protein
chr11_-_4018706 3.548 NM_144520
Sec14l2
SEC14-like 2 (S. cerevisiae)
chr4_-_150482562 3.508 Camta1
calmodulin binding transcription activator 1
chr18_-_33623069 3.503 NM_001109990
D0H4S114
DNA segment, human D4S114
chr14_-_55734213 3.422 NM_001003829
Jph4
junctophilin 4
chr5_-_77543903 3.372 Hopx
HOP homeobox
chr11_+_78136681 3.366 Aldoc
aldolase C, fructose-bisphosphate
chr7_-_31836457 3.358 NM_022007
Fxyd7
FXYD domain-containing ion transport regulator 7
chr3_+_122970332 3.318 NM_027135
Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr6_+_55402021 3.289 Adcyap1r1
adenylate cyclase activating polypeptide 1 receptor 1
chr13_+_118391270 3.252 Hcn1
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
chr4_-_93002201 3.228 NM_026954
Tusc1
tumor suppressor candidate 1
chr12_+_17697623 3.196 Hpcal1
hippocalcin-like 1
chr1_-_184212846 3.187 NM_007853
Degs1
degenerative spermatocyte homolog 1 (Drosophila)
chr5_-_143667004 3.185 Actb
actin, beta
chr2_+_164311639 3.111 NM_001048227
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr10_+_75052084 3.100 NM_011820
Ggt5
gamma-glutamyltransferase 5
chr14_+_60997156 3.097 Fam123a
family with sequence similarity 123, member A
chr17_-_25974021 3.090 NM_144816
Rhbdl1
rhomboid, veinlet-like 1 (Drosophila)
chr10_-_90586724 3.061 Slc25a3
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
chr1_+_43787692 3.016 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr2_-_25978296 2.990 Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr1_+_138028025 2.990 Kif21b
kinesin family member 21B
chr14_+_60997104 2.972 NM_001164705
NM_028113
Fam123a

family with sequence similarity 123, member A

chr4_-_57929087 2.962 NM_178727
D630039A03Rik
RIKEN cDNA D630039A03 gene
chr13_+_23830944 2.929 Hist1h1c
histone cluster 1, H1c
chr18_+_37975071 2.916 Pcdhgc4
protocadherin gamma subfamily C, 4
chr2_+_25733302 2.902 NM_175462
Kcnt1
potassium channel, subfamily T, member 1
chr10_-_20880559 2.802 NM_001198914
NM_010848
Myb

myeloblastosis oncogene

chr10_+_115738429 2.776 NM_029928
Ptprb
protein tyrosine phosphatase, receptor type, B
chr6_-_113451811 2.767 NM_172487
Prrt3
proline-rich transmembrane protein 3
chr17_-_33084274 2.756 NM_130882
Cyp4f13
cytochrome P450, family 4, subfamily f, polypeptide 13
chr17_+_33661120 2.755 NM_172619
Adamts10
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
chr14_-_56503058 2.715 Cbln3
cerebellin 3 precursor protein
chr6_-_59376283 2.698 NM_183183
Gprin3
GPRIN family member 3
chr4_-_91038638 2.660 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr5_+_138187182 2.645 NM_023910
Tsc22d4
TSC22 domain family, member 4
chr16_-_84835213 2.644 Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr17_-_26056379 2.641 NM_139154
Rab40c
Rab40c, member RAS oncogene family
chr11_-_109583524 2.626 NM_153782
Fam20a
family with sequence similarity 20, member A
chr1_+_93076578 2.608 Ramp1
receptor (calcitonin) activity modifying protein 1
chr7_+_28438881 2.556 NM_028417
Ttc9b
tetratricopeptide repeat domain 9B
chr1_+_173180542 2.536 NM_172845
Adamts4
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
chr10_-_18463500 2.514 NM_001033258
D10Bwg1379e
DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed
chr5_-_135223110 2.500 NM_007925
Eln
elastin
chr7_+_52105323 2.497 Akt1s1
AKT1 substrate 1 (proline-rich)
chr12_+_17697684 2.470


chr7_+_148641065 2.456 NM_001163689
NM_025802
Pnpla2

patatin-like phospholipase domain containing 2

chr1_-_178744138 2.400 Cep170
centrosomal protein 170
chr10_-_105011439 2.400 NM_177368
Tmtc2
transmembrane and tetratricopeptide repeat containing 2
chr6_-_115201790 2.399 Timp4
tissue inhibitor of metalloproteinase 4
chr12_+_78339999 2.399 NM_016893
Fut8
fucosyltransferase 8
chr7_+_138079669 2.387 NM_019564
Htra1
HtrA serine peptidase 1
chr1_-_93355838 2.386 Per2
period homolog 2 (Drosophila)
chr18_-_31476721 2.386 NM_009065
Rit2
Ras-like without CAAX 2
chrX_+_20265584 2.346 Cdk16
cyclin-dependent kinase 16
chr11_-_120092784 2.330 2900052L18Rik
RIKEN cDNA 2900052L18 gene
chr2_+_135485242 2.321 Plcb4
phospholipase C, beta 4
chr1_-_172040852 2.315 Ddr2
discoidin domain receptor family, member 2
chr1_-_137584672 2.305 Nav1
neuron navigator 1
chr14_-_78488780 2.299 NM_177629
AU021034
expressed sequence AU021034
chr15_+_54577256 2.264 NM_010930
Nov
nephroblastoma overexpressed gene
chr19_-_5801011 2.262 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr12_+_78340039 2.262 Fut8
fucosyltransferase 8
chr10_-_90586663 2.249 NM_133668
Slc25a3
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
chr11_+_53583515 2.239 NM_001159393
NM_008390
Irf1

interferon regulatory factor 1

chr6_+_72047758 2.186 St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr6_-_113451922 2.159 Prrt3
proline-rich transmembrane protein 3
chr17_+_24607576 2.156 Pgp
phosphoglycolate phosphatase
chr5_-_9725158 2.136 Grm3
glutamate receptor, metabotropic 3
chr12_+_16660521 2.124 Ntsr2
neurotensin receptor 2
chr1_+_155756310 2.108 Glul
glutamate-ammonia ligase (glutamine synthetase)
chr5_-_24606422 2.087 NM_145401
Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr19_-_5924796 2.076 Cdc42ep2
CDC42 effector protein (Rho GTPase binding) 2
chr12_-_111934580 2.056 NM_010480
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr1_+_51346108 2.054 Sdpr
serum deprivation response
chr10_+_78243274 2.026 Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr10_+_57504720 2.024 NM_021272
Fabp7
fatty acid binding protein 7, brain
chr5_+_23870625 2.008 NM_008713
Nos3
nitric oxide synthase 3, endothelial cell
chr6_+_135312948 2.004 NM_010128
Emp1
epithelial membrane protein 1
chr16_+_49855786 1.994 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr11_-_69734682 1.984 Eif5a
eukaryotic translation initiation factor 5A
chr2_+_102498839 1.964 NM_001077514
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_+_138027943 1.960 NM_001039472
Kif21b
kinesin family member 21B
chr9_-_75459125 1.951 NM_016711
Tmod2
tropomodulin 2
chr12_+_102017289 1.926 NM_145448
9030617O03Rik
RIKEN cDNA 9030617O03 gene
chr2_+_102498798 1.883 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr14_+_62950904 1.862 NM_026001
Rnaseh2b
ribonuclease H2, subunit B
chr15_-_75921924 1.853 Nrbp2
nuclear receptor binding protein 2
chr3_+_54559503 1.846 NM_019483
Smad9
MAD homolog 9 (Drosophila)
chr4_+_147534729 1.843 Fbxo2
F-box protein 2
chr5_-_104542641 1.816 Sparcl1
SPARC-like 1
chr1_+_196765124 1.811 Cd34
CD34 antigen
chr10_+_90292453 1.811 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr17_+_45692647 1.801 NM_008690
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr11_-_18918923 1.788 NM_001193271
NM_010789
Meis1

Meis homeobox 1

chr3_-_37211319 1.777 NM_145825
Cetn4
centrin 4
chr19_+_3323339 1.775 Cpt1a
carnitine palmitoyltransferase 1a, liver
chr6_+_55401971 1.769 NM_001025372
NM_007407
Adcyap1r1

adenylate cyclase activating polypeptide 1 receptor 1

chr3_-_117063317 1.748 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr19_-_42826956 1.733 Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr1_-_66909822 1.721 NM_007381
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
chr12_+_104672380 1.717 NM_026790
NM_194066
NM_194067
NM_194068
NM_194069
Ifi27l1




interferon, alpha-inducible protein 27 like 1




chr11_-_69734574 1.717 NM_001166596
Eif5a
eukaryotic translation initiation factor 5A
chr12_+_72149332 1.711 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr9_-_75257067 1.708 NM_027418
Mapk6
mitogen-activated protein kinase 6
chr11_+_69831951 1.705 NM_001109752
NM_007864
Dlg4

discs, large homolog 4 (Drosophila)

chr16_+_23429205 1.704 NM_001004151
Rtp1
receptor transporter protein 1
chr10_-_127058199 1.697 NM_008512
Lrp1
low density lipoprotein receptor-related protein 1
chr2_-_168559743 1.695 Atp9a
ATPase, class II, type 9A
chr15_+_40486630 1.694 Zfpm2
zinc finger protein, multitype 2
chr11_-_118216819 1.693 Timp2
tissue inhibitor of metalloproteinase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
1.99 8.11e-04 GO:0048519 negative regulation of biological process
1.77 2.65e-03 GO:0032502 developmental process
1.80 3.37e-03 GO:0007275 multicellular organismal development
7.36 3.80e-03 GO:0006865 amino acid transport
1.82 4.59e-03 GO:0048518 positive regulation of biological process
5.50 5.54e-03 GO:0071705 nitrogen compound transport
2.38 6.43e-03 GO:0007399 nervous system development
1.88 7.44e-03 GO:0048731 system development
2.45 1.14e-02 GO:0050793 regulation of developmental process
4.29 1.21e-02 GO:0007268 synaptic transmission
51.01 1.58e-02 GO:0042940 D-amino acid transport
1.79 1.62e-02 GO:0048856 anatomical structure development
5.32 2.01e-02 GO:0046942 carboxylic acid transport
1.89 2.01e-02 GO:0048523 negative regulation of cellular process
1.81 2.10e-02 GO:0048522 positive regulation of cellular process
3.41 2.12e-02 GO:0007267 cell-cell signaling
5.25 2.24e-02 GO:0015849 organic acid transport
10.01 2.86e-02 GO:0003333 amino acid transmembrane transport
3.48 3.10e-02 GO:0007610 behavior
3.66 3.34e-02 GO:0019226 transmission of nerve impulse
3.66 3.34e-02 GO:0035637 multicellular organismal signaling
2.08 3.86e-02 GO:0051239 regulation of multicellular organismal process
5.39 4.70e-02 GO:0015837 amine transport

Gene overrepresentation in compartment category:

enrichment p-value GO term description
3.31 3.62e-08 GO:0044421 extracellular region part
5.53 3.94e-08 GO:0031012 extracellular matrix
5.69 1.81e-07 GO:0005578 proteinaceous extracellular matrix
2.91 1.12e-06 GO:0042995 cell projection
3.83 1.51e-06 GO:0043005 neuron projection
2.39 6.33e-04 GO:0000267 cell fraction
2.58 1.01e-03 GO:0005626 insoluble fraction
4.18 1.15e-03 GO:0030425 dendrite
2.81 1.33e-03 GO:0005615 extracellular space
2.04 1.40e-03 GO:0005576 extracellular region
3.32 1.46e-03 GO:0009986 cell surface
2.50 3.83e-03 GO:0005624 membrane fraction
3.03 7.98e-03 GO:0045202 synapse
8.80 9.22e-03 GO:0005901 caveola
3.32 2.54e-02 GO:0044456 synapse part
3.27 2.94e-02 GO:0044297 cell body
6.81 3.89e-02 GO:0044309 neuron spine
3.60 4.09e-02 GO:0030424 axon

Gene overrepresentation in function category:

enrichment p-value GO term description
1.66 7.61e-07 GO:0005515 protein binding
1.29 7.09e-04 GO:0005488 binding