Motif ID: TP53.p2

Z-value: 0.738

Transcription factors associated with TP53.p2:

NameEntrezDescription
Trp53 22059 transformation related protein 53

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Trp53chr11_+_69393851-0.124.8e-01Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr9_-_123760992 6.522 NM_001110253
Fyco1
FYVE and coiled-coil domain containing 1
chr5_+_37259780 4.375 NM_172994
Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr6_+_103461323 3.286 Chl1
cell adhesion molecule with homology to L1CAM
chr17_+_56904233 3.012 Dus3l
dihydrouridine synthase 3-like (S. cerevisiae)
chr18_+_66618186 2.680 NM_021451
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr4_-_128798481 2.423 NM_010471
Hpca
hippocalcin
chr17_+_3326513 2.375 NM_001122998
Tiam2
T-cell lymphoma invasion and metastasis 2
chr2_-_26236126 1.825 NM_172339
Snapc4
small nuclear RNA activating complex, polypeptide 4
chr6_+_103460955 1.564 Chl1
cell adhesion molecule with homology to L1CAM
chr4_+_148478321 1.388 Dffa
DNA fragmentation factor, alpha subunit
chr5_+_37633353 1.361 Crmp1
collapsin response mediator protein 1
chr7_+_107855164 1.340 Fam168a
family with sequence similarity 168, member A
chr9_-_75459125 1.290 NM_016711
Tmod2
tropomodulin 2
chr5_+_37259906 1.272 Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr15_+_80808238 1.242 Sgsm3
small G protein signaling modulator 3
chr17_+_56904162 1.189 NM_144858
Dus3l
dihydrouridine synthase 3-like (S. cerevisiae)
chr10_-_127935725 1.188 NM_172259
Myl6b
myosin, light polypeptide 6B
chr8_-_112692071 1.101 NM_007586
Calb2
calbindin 2
chr7_+_107855215 1.049 NM_178764
Fam168a
family with sequence similarity 168, member A
chr11_-_64976408 1.011 NM_001099288
NM_175003
Arhgap44

Rho GTPase activating protein 44

chr15_+_80808194 0.937 NM_134091
Sgsm3
small G protein signaling modulator 3
chr5_+_25265761 0.910 NM_001004365
Actr3b
ARP3 actin-related protein 3 homolog B (yeast)
chr17_+_35958628 0.907 NM_133662
Ier3
immediate early response 3
chr4_+_124419069 0.861 Inpp5b
inositol polyphosphate-5-phosphatase B
chr8_-_86265035 0.859 NM_001163029
NM_001163030
NM_001163031
NM_011925
Cd97



CD97 antigen



chr3_+_131227808 0.858 Papss1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr1_-_95532270 0.848 Stk25
serine/threonine kinase 25 (yeast)
chr9_-_75458865 0.841 Tmod2
tropomodulin 2
chr18_+_4634964 0.810


chr9_+_51573434 0.803 NM_175535
Arhgap20
Rho GTPase activating protein 20
chr7_-_135039020 0.792 NM_178600
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr12_-_20927090 0.765 3110053B16Rik
RIKEN cDNA 3110053B16 gene
chr2_+_157740281 0.765 NM_198627
Vstm2l
V-set and transmembrane domain containing 2-like
chr1_-_95532278 0.744 NM_021537
Stk25
serine/threonine kinase 25 (yeast)
chr15_+_78258993 0.730 NM_001081367
Kctd17
potassium channel tetramerisation domain containing 17
chr9_-_44607274 0.709 NM_027865
Tmem25
transmembrane protein 25
chr2_-_58998590 0.695 NM_001001178
Ccdc148
coiled-coil domain containing 148
chr7_-_26022753 0.693 NM_001031667
Gsk3a
glycogen synthase kinase 3 alpha
chr9_-_75458918 0.660 Tmod2
tropomodulin 2
chr9_-_75459046 0.654 Tmod2
tropomodulin 2
chr6_+_66986637 0.643 E230016M11Rik
RIKEN cDNA E230016M11 gene
chr18_+_4634926 0.633 NM_001081963
9430020K01Rik
RIKEN cDNA 9430020K01 gene
chr7_+_51640108 0.617 Syt3
synaptotagmin III
chr16_+_13671936 0.585 NM_001177552
NM_025976
3110001I22Rik
Bfar

RIKEN cDNA 3110001I22 gene
bifunctional apoptosis regulator

chr1_-_17087915 0.579 Jph1
junctophilin 1
chr6_+_3448385 0.572 NM_001167750
NM_001167751
NM_024260
Ccdc132


coiled-coil domain containing 132


chr2_-_38142866 0.570 NM_146122
Dennd1a
DENN/MADD domain containing 1A
chr13_+_38436987 0.557 Bmp6
bone morphogenetic protein 6
chr2_+_131735663 0.556 NM_011170
Prnp
prion protein
chr6_+_39542563 0.555 NM_026612
Ndufb2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2
chr2_-_4985090 0.539 Optn
optineurin
chr10_-_128002987 0.535 NM_011119
Pa2g4
proliferation-associated 2G4
chr8_+_122386155 0.531 NM_146219
Klhl36
kelch-like 36 (Drosophila)
chr19_+_5741862 0.526 Ltbp3
latent transforming growth factor beta binding protein 3
chr6_+_83004687 0.509 Aup1
ancient ubiquitous protein 1
chr9_-_56995928 0.509 Neil1
nei endonuclease VIII-like 1 (E. coli)
chr11_-_59041663 0.505 NM_001130408
Arf1
ADP-ribosylation factor 1
chr11_-_59041767 0.496 NM_007476
Arf1
ADP-ribosylation factor 1
chr9_+_72833379 0.479 Ccpg1
cell cycle progression 1
chr2_+_172171015 0.475 NM_025912
2010011I20Rik
RIKEN cDNA 2010011I20 gene
chr6_+_105627738 0.468 NM_001109749
NM_173004
Cntn4

contactin 4

chr7_+_29551728 0.461 NM_001122765
NM_001122766
NM_022432
Sirt2


sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)


chr5_-_124637176 0.455 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr10_-_128003058 0.454 Pa2g4
proliferation-associated 2G4
chr7_-_29551532 0.454 NM_010908
Nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr19_+_6341137 0.450 NM_009006
Map4k2
mitogen-activated protein kinase kinase kinase kinase 2
chr11_-_40568710 0.435 NM_009831
Ccng1
cyclin G1
chr9_-_59334089 0.430 NM_019927
Arih1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
chr13_+_93381086 0.419 NM_172588
Serinc5
serine incorporator 5
chr17_+_35960291 0.402 NM_008027
Flot1
flotillin 1
chr9_-_114842996 0.402 Gpd1l
glycerol-3-phosphate dehydrogenase 1-like
chr12_+_112512884 0.395 Amn
amnionless
chr9_+_72833327 0.390 NM_001114328
NM_028181
Ccpg1

cell cycle progression 1

chr2_+_58998885 0.384 NM_026361
NM_175464
Pkp4

plakophilin 4

chr11_+_78075242 0.382 NM_001002004
2610507B11Rik
RIKEN cDNA 2610507B11 gene
chr11_+_54911540 0.381 NM_010299
Gm2a
GM2 ganglioside activator protein
chr1_-_95532242 0.380 Stk25
serine/threonine kinase 25 (yeast)
chr4_+_132567420 0.379 NM_146155
Ahdc1
AT hook, DNA binding motif, containing 1
chr8_-_114378162 0.373 NM_011801
Cfdp1
craniofacial development protein 1
chr5_-_110877489 0.372 NM_001142642
Fbrsl1
fibrosin-like 1
chr13_+_93381078 0.371 Serinc5
serine incorporator 5
chr4_-_131394135 0.370 NM_001083119
NM_011214
Ptpru

protein tyrosine phosphatase, receptor type, U

chr4_-_57155985 0.370 Epb4.1l4b
erythrocyte protein band 4.1-like 4b
chr8_+_96910392 0.369 NM_022331
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chrX_-_98615554 0.368 NM_001177988
NM_019831
Zmym3

zinc finger, MYM-type 3

chr1_-_173126368 0.356 NM_025557
Pcp4l1
Purkinje cell protein 4-like 1
chr6_+_90554873 0.356 NM_027868
Slc41a3
solute carrier family 41, member 3
chr1_+_91351435 0.354 Agap1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr10_-_120913138 0.345 NM_138956
Rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr11_-_32167657 0.339 Nprl3
nitrogen permease regulator-like 3 (S. cerevisiae)
chr10_-_80945445 0.337 NM_176954
Celf5
CUGBP, Elav-like family member 5
chr1_-_186669499 0.337 NM_133684
Mosc2
MOCO sulphurase C-terminal domain containing 2
chr11_+_60351159 0.336 NM_172943
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chrX_-_35988248 0.336 C1galt1c1
C1GALT1-specific chaperone 1
chr8_-_82581887 0.335 NM_020259
Hhip
Hedgehog-interacting protein
chr9_-_75458954 0.329 Tmod2
tropomodulin 2
chr4_-_154338457 0.328 Pank4
pantothenate kinase 4
chr6_-_83004374 0.326 NM_019752
Htra2
HtrA serine peptidase 2
chr14_-_103381744 0.323 NM_177715
Kctd12
potassium channel tetramerisation domain containing 12
chr11_+_22872062 0.322 Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr5_+_137994744 0.318 NM_031404
Actl6b
actin-like 6B
chr17_-_66868909 0.316 NM_024448
Rab12
RAB12, member RAS oncogene family
chr11_+_22872016 0.308 NM_011663
Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr12_+_3365102 0.307 NM_008445
Kif3c
kinesin family member 3C
chr8_+_73017009 0.307 NM_018827
Crlf1
cytokine receptor-like factor 1
chr13_-_49063376 0.304 Fam120a
family with sequence similarity 120, member A
chr15_+_97614772 0.300 NM_026353
Slc48a1
solute carrier family 48 (heme transporter), member 1
chr10_-_67011689 0.299 NM_001005419
Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr13_-_53472732 0.299 Sptlc1
serine palmitoyltransferase, long chain base subunit 1
chr2_-_17652669 0.298 NM_028757
Nebl
nebulette
chr2_+_58999028 0.297 Pkp4
plakophilin 4
chr8_+_75095914 0.291 NM_144534
Nwd1
Tmem38a
NACHT and WD repeat domain containing 1
transmembrane protein 38A
chr9_+_74919341 0.285 Myo5a
myosin VA
chr6_-_146583036 0.285 NM_026281
Tm7sf3
transmembrane 7 superfamily member 3
chr2_+_58998938 0.284 Pkp4
plakophilin 4
chr15_+_78939582 0.283 Micall1
microtubule associated monoxygenase, calponin and LIM domain containing -like 1
chr7_-_99785544 0.279 NM_028665
Ankrd42
ankyrin repeat domain 42
chr12_+_77471173 0.279 NM_178744
Zbtb1
zinc finger and BTB domain containing 1
chrX_+_45872593 0.274 NM_011228
Rab33a
RAB33A, member of RAS oncogene family
chr16_-_21333381 0.272 Magef1
melanoma antigen family F, 1
chr2_-_166821559 0.271 NM_001109905
NM_001109906
NM_011490
Stau1


staufen (RNA binding protein) homolog 1 (Drosophila)


chr11_-_106077657 0.270 NM_026009
Ccdc47
coiled-coil domain containing 47
chr6_-_86798929 0.270 2610306M01Rik
RIKEN cDNA 2610306M01 gene
chr19_-_50752974 0.266 NM_021377
Sorcs1
VPS10 domain receptor protein SORCS 1
chr6_+_143115732 0.260 NM_029250
Etnk1
ethanolamine kinase 1
chr18_-_43059156 0.253 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr2_+_179992080 0.252 NM_025587
Rps21
ribosomal protein S21
chr1_-_21951497 0.251 Kcnq5
potassium voltage-gated channel, subfamily Q, member 5
chr2_+_118489457 0.250 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_35582969 0.248 NM_145962
Pank3
pantothenate kinase 3
chr9_-_114843103 0.246 NM_175380
Gpd1l
glycerol-3-phosphate dehydrogenase 1-like
chr2_-_91864276 0.242 NM_011957
Creb3l1
cAMP responsive element binding protein 3-like 1
chr7_+_16894925 0.238 NM_133234
Bbc3
BCL2 binding component 3
chr9_+_21125147 0.233 Slc44a2
solute carrier family 44, member 2
chrX_+_147778717 0.233 NM_198105
Fam120c
family with sequence similarity 120, member C
chr15_-_53733989 0.231 NM_177225
Samd12
sterile alpha motif domain containing 12
chr2_-_163470841 0.229 Serinc3
serine incorporator 3
chr2_-_163470787 0.226 Serinc3
serine incorporator 3
chr15_-_53734033 0.222 Samd12
sterile alpha motif domain containing 12
chr19_-_57389371 0.221 Ablim1
actin-binding LIM protein 1
chr9_+_32503600 0.218 NM_001038642
NM_011808
Ets1

E26 avian leukemia oncogene 1, 5' domain

chr16_-_32868355 0.216 NM_172615
1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr1_-_178744138 0.213 Cep170
centrosomal protein 170
chr11_+_35583304 0.208 Pank3
pantothenate kinase 3
chr17_-_26122737 0.208 Solh
small optic lobes homolog (Drosophila)
chr2_+_135485242 0.207 Plcb4
phospholipase C, beta 4
chr15_+_82086506 0.206 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr12_+_3365147 0.204 Kif3c
kinesin family member 3C
chrX_+_53599573 0.199 NM_030139
Zfp449
zinc finger protein 449
chr12_-_80273320 0.196 NM_016800
Vti1b
vesicle transport through interaction with t-SNAREs 1B homolog
chr4_-_57156022 0.195 NM_019427
Epb4.1l4b
erythrocyte protein band 4.1-like 4b
chrX_-_99700697 0.194 Hdac8
histone deacetylase 8
chr10_+_81038028 0.194 NM_019725
Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr2_+_153171562 0.194 Asxl1
additional sex combs like 1 (Drosophila)
chr5_-_108561512 0.194 NM_028876
Tmed5
transmembrane emp24 protein transport domain containing 5
chr17_-_24664876 0.192 NM_001172113
NM_001172114
NM_153792
Traf7


TNF receptor-associated factor 7


chr6_+_86799460 0.191 NM_001040106
NM_177762
Aak1

AP2 associated kinase 1

chr17_-_34027547 0.191 Kifc1
kinesin family member C1
chr8_-_118230828 0.188 Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr9_+_65193874 0.186 NM_016688
Pdcd7
programmed cell death 7
chr13_-_53472719 0.186 NM_009269
Sptlc1
serine palmitoyltransferase, long chain base subunit 1
chr7_-_88490106 0.185 NM_009092
Rps17
ribosomal protein S17
chr13_-_49063188 0.185 NM_001033268
Fam120a
family with sequence similarity 120, member A
chr13_-_102538106 0.185 NM_001077495
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr6_+_125299717 0.184 NM_011609
Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
chr5_-_74464390 0.183 NM_177561
Usp46
ubiquitin specific peptidase 46
chr17_+_27053979 0.183 NM_053173
Kifc5b
kinesin family member C5B
chr12_+_3235481 0.183 1700012B15Rik
RIKEN cDNA 1700012B15 gene
chrX_-_35988178 0.182 C1galt1c1
C1GALT1-specific chaperone 1
chr4_+_98213324 0.182 NM_001005787
NM_007704
Inadl

InaD-like (Drosophila)

chr10_+_78243274 0.179 Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr12_+_77356170 0.179 NM_138745
Mthfd1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
chr2_-_163470870 0.177 NM_012032
Serinc3
serine incorporator 3
chr12_-_4848240 0.177 NM_016863
Fkbp1b
FK506 binding protein 1b
chr7_+_25184637 0.176 NM_028047
1500002O20Rik
RIKEN cDNA 1500002O20 gene
chr5_+_123093892 0.176 NM_001038839
NM_001038845
NM_001038887
NM_011027
P2rx7



purinergic receptor P2X, ligand-gated ion channel, 7



chr11_-_70051346 0.175 0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr3_+_28680248 0.175 Eif5a2
eukaryotic translation initiation factor 5A2
chr17_+_74927634 0.174 NM_007566
Birc6
baculoviral IAP repeat-containing 6
chr12_+_10397567 0.171 NM_023697
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr15_+_78939343 0.171 NM_177461
Micall1
microtubule associated monoxygenase, calponin and LIM domain containing -like 1
chr9_+_103904873 0.170 NM_028721
NM_172460
Nphp3

nephronophthisis 3 (adolescent)

chr2_-_163470826 0.168 Serinc3
serine incorporator 3
chr5_-_92391581 0.167 Thap6
Rchy1
THAP domain containing 6
ring finger and CHY zinc finger domain containing 1
chr7_+_64845887 0.165 NM_001038701
Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr18_-_35862744 0.165 NM_029669
Dnajc18
DnaJ (Hsp40) homolog, subfamily C, member 18
chr19_-_46470175 0.165 NM_016860
Actr1a
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr11_+_3388229 0.164 NM_172791
Pla2g3
phospholipase A2, group III
chr9_-_108166193 0.164 Dag1
dystroglycan 1
chr12_+_113858217 0.163 NM_007421
Adssl1
adenylosuccinate synthetase like 1
chr13_+_49063548 0.163 C030044B11Rik
RIKEN cDNA C030044B11 gene
chr2_-_17652725 0.162 Nebl
nebulette
chr7_-_148068161 0.160 NM_022433
Sirt3
sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
chr1_-_95532227 0.158 Stk25
serine/threonine kinase 25 (yeast)
chr10_+_122116022 0.157


chr10_-_34138271 0.155 NM_176968
Nt5dc1
5'-nucleotidase domain containing 1
chr13_-_55464135 0.154 NM_025828
Lman2
lectin, mannose-binding 2
chr7_+_109416314 0.153 NM_009287
Stim1
stromal interaction molecule 1
chr8_+_109555200 0.153 NM_126165
Vps4a
vacuolar protein sorting 4a (yeast)
chr12_+_84861415 0.151 NM_030246
Dcaf4
DDB1 and CUL4 associated factor 4

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment p-value GO term description
92.38 7.42e-03 GO:0005921 gap junction

Gene overrepresentation in function category:

enrichment p-value GO term description
17.54 9.80e-03 GO:0005096 GTPase activator activity