Motif ID: UUGUUCG

Z-value: 0.704

Mature miRNA associated with seed UUGUUCG:

NamemiRBase Accession
mmu-miR-375 MIMAT0000739



Activity profile for motif UUGUUCG.

activity profile for motif UUGUUCG


Sorted Z-values histogram for motif UUGUUCG

Sorted Z-values for motif UUGUUCG



Network of associatons between targets according to the STRING database.



First level regulatory network of UUGUUCG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr3_+_5218545 5.439 NM_030708
Zfhx4
zinc finger homeodomain 4
chr4_-_109960078 3.795 NM_001038698
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr14_-_104867215 2.732 NM_011143
Pou4f1
POU domain, class 4, transcription factor 1
chr1_-_157264398 2.488 NM_011273
Xpr1
xenotropic and polytropic retrovirus receptor 1
chr9_-_99776467 2.277 NM_011440
Sox14
SRY-box containing gene 14
chr6_+_30688050 2.270 NM_008590
Mest
mesoderm specific transcript
chr1_-_176851949 2.263 NM_011825
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr5_+_53981453 2.216 NM_009035
NM_001080927
Rbpj

recombination signal binding protein for immunoglobulin kappa J region

chr15_-_56526052 2.073 NM_008216
Has2
hyaluronan synthase 2
chr9_+_47338431 1.992 NM_001025600
NM_018770
NM_207675
NM_207676
Cadm1



cell adhesion molecule 1



chr4_-_91042997 1.986 NM_001177883
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chrX_+_97972559 1.877 NM_001177780
Dlg3
discs, large homolog 3 (Drosophila)
chr19_-_19185685 1.851 NM_001043354
Rorb
RAR-related orphan receptor beta
chr4_-_91066674 1.786 NM_207685
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr19_+_29326204 1.782 NM_001048177
NM_008413
Jak2

Janus kinase 2

chr14_+_67852128 1.776 NM_010095
Ebf2
early B-cell factor 2
chr9_-_8004559 1.736 NM_001171147
NM_009534
Yap1

yes-associated protein 1

chr4_+_43071852 1.733 NM_001081413
NM_021468
Unc13b

unc-13 homolog B (C. elegans)

chr14_-_118636251 1.679 NM_177753
Sox21
SRY-box containing gene 21
chr2_+_160471623 1.672 NM_009408
Top1
topoisomerase (DNA) I
chr13_-_76081244 1.632 NM_028493
Rhobtb3
Rho-related BTB domain containing 3
chr14_-_104243379 1.587 NM_001136061
Ednrb
endothelin receptor type B
chr2_-_24775083 1.488 NM_001012518
NM_001109686
NM_001109687
NM_172545
Ehmt1



euchromatic histone methyltransferase 1



chr13_-_104124527 1.440 NM_175171
Mast4
microtubule associated serine/threonine kinase family member 4
chr11_-_63735652 1.363 NM_018805
Hs3st3b1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr18_-_75120759 1.290 NM_010720
Lipg
lipase, endothelial
chrX_+_103222548 1.280 NM_001109757
NM_009726
Atp7a

ATPase, Cu++ transporting, alpha polypeptide

chr4_+_148178500 1.258 NM_001159344
NM_027195
Casz1

castor homolog 1, zinc finger (Drosophila)

chr1_+_53353919 1.257 NM_145517
Ormdl1
ORM1-like 1 (S. cerevisiae)
chr19_+_59335367 1.238 NM_172523
Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr11_+_103635438 1.213 NM_009521
Wnt3
wingless-related MMTV integration site 3
chr12_-_60112987 1.201 NM_009147
Sec23a
SEC23A (S. cerevisiae)
chr18_-_46372017 1.172 NM_178872
Trim36
tripartite motif-containing 36
chr13_-_40829082 1.170 NM_011547
Tcfap2a
transcription factor AP-2, alpha
chr2_+_68699498 1.169 NM_172856
Lass6
LAG1 homolog, ceramide synthase 6
chr15_-_79272478 1.146 NM_013767
Csnk1e
casein kinase 1, epsilon
chr17_-_24833089 1.078 NM_023040
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr7_-_128125714 1.067 NM_007672
Cdr2
cerebellar degeneration-related 2
chr2_+_28980511 1.041 NM_198033
Setx
senataxin
chr15_+_102236709 0.996 NM_013672
Sp1
trans-acting transcription factor 1
chr10_-_126971614 0.993 NM_183297
Nxph4
neurexophilin 4
chr2_+_37631768 0.965 NM_001163566
Crb2
crumbs homolog 2 (Drosophila)
chr5_+_108494692 0.963 NM_013827
Mtf2
metal response element binding transcription factor 2
chrX_+_104115963 0.951 NM_175271
Lpar4
lysophosphatidic acid receptor 4
chr11_-_89163840 0.941 NM_008711
Nog
noggin
chr5_-_24414236 0.938 NM_001170555
NM_001170556
Prkag2

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

chr2_+_61642509 0.933 NM_009322
Tbr1
T-box brain gene 1
chr1_-_183950050 0.925 NM_001083120
NM_001083121
NM_008680
NM_010135
Enah



enabled homolog (Drosophila)



chr7_-_135883942 0.925 NM_145955
Mcmbp
MCM (minichromosome maintenance deficient) binding protein
chr13_-_104968472 0.911 NM_001093759
NM_001093760
NM_025879
2410002O22Rik


RIKEN cDNA 2410002O22 gene


chr4_-_109959366 0.909 NM_001163399
NM_010488
Elavl4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chrX_-_53851046 0.881 NM_146234
Mmgt1
membrane magnesium transporter 1
chr6_-_30643681 0.859 NM_031998
Tsga14
testis specific gene A14
chr6_+_83276009 0.854 NM_145571
Mobkl1b
MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr18_+_42435006 0.818 NM_172626
Rbm27
RNA binding motif protein 27
chrX_+_50265390 0.799 NM_027642
Phf6
PHD finger protein 6
chr3_+_32716447 0.793 NM_001013024
Usp13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr5_+_67651890 0.753 NM_028975
NM_030108
Tmem33

transmembrane protein 33

chr9_-_62828677 0.738 NM_019663
Pias1
protein inhibitor of activated STAT 1
chr18_+_23910833 0.733 NM_001162942
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr17_-_80606644 0.722 NM_001195485
NM_001195486
NM_001195487
NM_146083
Srsf7



serine/arginine-rich splicing factor 7



chr2_+_28496752 0.661 NM_022887
Tsc1
tuberous sclerosis 1
chr11_-_78510874 0.627 NM_008702
Nlk
nemo like kinase
chr16_-_22163264 0.625 NM_183029
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr7_+_73254341 0.624 NM_001081163
Chsy1
chondroitin sulfate synthase 1
chr11_+_77499638 0.622 NM_001024205
Nufip2
nuclear fragile X mental retardation protein interacting protein 2
chr3_-_106350628 0.620 NM_133869
Cept1
choline/ethanolaminephosphotransferase 1
chr6_+_67216948 0.601 NM_001113564
NM_001113565
NM_001113566
NM_025814
Serbp1



serpine1 mRNA binding protein 1



chr8_+_109674517 0.600 NM_025558
Cyb5b
cytochrome b5 type B
chr3_+_108087046 0.595 NM_019972
Sort1
sortilin 1
chr18_-_58369579 0.584 NM_010181
Fbn2
fibrillin 2
chr11_-_106054817 0.571 NM_028126
Strada
STE20-related kinase adaptor alpha
chr19_+_18787654 0.568 NM_177640
D030056L22Rik
RIKEN cDNA D030056L22 gene
chr18_+_44540137 0.566 NM_027490
Dcp2
DCP2 decapping enzyme homolog (S. cerevisiae)
chr9_-_21856445 0.566 NM_010487
Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr6_-_86619001 0.561 NM_010751
Mxd1
MAX dimerization protein 1
chr7_+_66484094 0.536 NM_173010
NM_001033962
NM_011668
Ube3a


ubiquitin protein ligase E3A


chr19_-_4906607 0.512 NM_001033128
Bbs1
Bardet-Biedl syndrome 1 (human)
chr6_-_13627853 0.506 NM_175312
B630005N14Rik
RIKEN cDNA B630005N14 gene
chr1_-_64784316 0.506 NM_001042659
NM_022721
Fzd5

frizzled homolog 5 (Drosophila)

chr2_-_52280367 0.504 NM_182994
Arl5a
ADP-ribosylation factor-like 5A
chr13_+_112476313 0.501 NM_172593
Mier3
mesoderm induction early response 1, family member 3
chr14_+_47502637 0.497 NM_001037221
NM_028966
Samd4

sterile alpha motif domain containing 4

chr1_-_127808790 0.494 NM_145100
Lypd1
Ly6/Plaur domain containing 1
chr2_-_38781939 0.488 NM_010264
Nr6a1
nuclear receptor subfamily 6, group A, member 1
chr4_+_133140278 0.488 NM_133884
Gpn2
GPN-loop GTPase 2
chr19_-_29880498 0.481 NM_172836
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr2_-_152223710 0.481 NM_011438
Sox12
SRY-box containing gene 12
chr14_+_14845004 0.473 NM_139227
Atxn7
ataxin 7
chr13_-_40825789 0.472 NM_001122948
Tcfap2a
transcription factor AP-2, alpha
chr8_-_93837120 0.465 NM_173431
Rpgrip1l
Rpgrip1-like
chr7_+_52151432 0.451 NM_027376
Fuz
fuzzy homolog (Drosophila)
chr10_-_128258639 0.448 NM_024180
Ormdl2
ORM1-like 2 (S. cerevisiae)
chr12_+_36883692 0.436 NM_146033
Ankmy2
ankyrin repeat and MYND domain containing 2
chr13_-_64376186 0.432 NM_172587
Cdc14b
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr9_+_54711492 0.432 NM_022655
Ireb2
iron responsive element binding protein 2
chr9_+_122714664 0.428 NM_001013405
D9Ertd402e
DNA segment, Chr 9, ERATO Doi 402, expressed
chr19_+_53384990 0.426 NM_001008542
Mxi1
Max interacting protein 1
chr11_-_102046532 0.424 NM_172947
Lsm12
LSM12 homolog (S. cerevisiae)
chr10_+_128184908 0.417 NM_030100
Wibg
within bgcn homolog (Drosophila)
chr6_-_91465788 0.417 NM_009531
Xpc
xeroderma pigmentosum, complementation group C
chr7_+_119822831 0.416 NM_001166584
NM_009346
Tead1

TEA domain family member 1

chr2_-_12932442 0.414 NM_153155
C1ql3
C1q-like 3
chr10_+_24315247 0.412 NM_010217
Ctgf
connective tissue growth factor
chr4_+_53644336 0.405 NM_001195284
NM_176966
Fsd1l

fibronectin type III and SPRY domain containing 1-like

chr15_+_97998090 0.401 NM_177716
AI836003
expressed sequence AI836003
chr17_-_36408313 0.398 NM_178281
Trim39
tripartite motif-containing 39
chr7_-_144506112 0.397 NM_001113414
NM_001113415
NM_010096
Ebf3


early B-cell factor 3


chr14_-_118531951 0.384 NM_029578
Tgds
TDP-glucose 4,6-dehydratase
chr4_-_123427465 0.379 NM_023423
Akirin1
akirin 1
chr13_+_9275741 0.379 NM_001081426
Dip2c
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr2_+_4802609 0.371 NM_175400
Sephs1
selenophosphate synthetase 1
chr11_-_70796471 0.370 NM_007573
C1qbp
complement component 1, q subcomponent binding protein
chr4_-_45543623 0.370 NM_001033306
Shb
src homology 2 domain-containing transforming protein B
chr18_-_46358466 0.361 NM_001170855
Trim36
tripartite motif-containing 36
chr18_+_23962468 0.358 NM_153058
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr9_-_71959599 0.358 NM_011544
Tcf12
transcription factor 12
chr6_+_141578016 0.352 NM_020495
Slco1b2
solute carrier organic anion transporter family, member 1b2
chr12_+_21117592 0.342 NM_001004364
NM_001098168
NM_001135192
Asap2


ArfGAP with SH3 domain, ankyrin repeat and PH domain 2


chr1_+_78654399 0.342 NM_001001981
NM_001033606
NM_001136222
NM_028817
Utp14b
Acsl3


UTP14, U3 small nucleolar ribonucleoprotein, homolog B (yeast)
acyl-CoA synthetase long-chain family member 3


chr5_-_72559220 0.341 NM_178599
Commd8
COMM domain containing 8
chr11_-_115873976 0.337 NM_016905
Galk1
galactokinase 1
chr10_+_68186493 0.327 NM_177794
Tmem26
transmembrane protein 26
chr9_+_64808638 0.323 NM_001077631
NM_175153
2010321M09Rik

RIKEN cDNA 2010321M09 gene

chr15_-_50721552 0.317 NM_032000
Trps1
trichorhinophalangeal syndrome I (human)
chr5_-_108304062 0.317 NM_007964
Evi5
ecotropic viral integration site 5
chr1_+_140860285 0.317 NM_001166501
Dennd1b
DENN/MADD domain containing 1B
chr8_+_34710049 0.313 NM_017374
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr19_+_37281988 0.308 NM_001164336
NM_001164337
NM_027314
March5


membrane-associated ring finger (C3HC4) 5


chr7_-_139791248 0.306 NM_009123
Nkx1-2
NK1 transcription factor related, locus 2 (Drosophila)
chr2_+_121854287 0.303 NM_144545
Eif3j
eukaryotic translation initiation factor 3, subunit J
chr10_-_112365976 0.288 NM_001033474
Atxn7l3b
ataxin 7-like 3B
chr10_+_52137324 0.287 NM_030250
Nus1
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
chr4_-_55545337 0.286 NM_010637
Klf4
Kruppel-like factor 4 (gut)
chr16_+_22009551 0.285 NM_029457
Senp2
SUMO/sentrin specific peptidase 2
chr3_+_53267715 0.280 NM_173382
2810046L04Rik
RIKEN cDNA 2810046L04 gene
chr10_+_98569715 0.276 NM_027740
Poc1b
POC1 centriolar protein homolog B (Chlamydomonas)
chr2_-_136213509 0.275 NM_172858
Pak7
p21 protein (Cdc42/Rac)-activated kinase 7
chrX_+_130593867 0.272 NM_133196
Cstf2
cleavage stimulation factor, 3' pre-RNA subunit 2
chr8_+_28134259 0.262 NM_153592
Erlin2
ER lipid raft associated 2
chr1_+_138521477 0.261 NM_001160251
NM_177643
Zfp281

zinc finger protein 281

chr8_-_114400574 0.261 NM_025781
Tmem170
transmembrane protein 170
chr4_-_84320976 0.255 NM_172870
Bnc2
basonuclin 2
chr5_-_31482504 0.251 NM_027901
Gtf3c2
general transcription factor IIIC, polypeptide 2, beta
chr3_-_107957795 0.250 NM_175470
Gpr61
G protein-coupled receptor 61
chr10_+_7400978 0.247 NM_010690
Lats1
large tumor suppressor
chr4_-_131700278 0.245 NM_013622
Oprd1
opioid receptor, delta 1
chr18_+_36720238 0.243 NM_175375
Ankhd1
ankyrin repeat and KH domain containing 1
chr15_-_36724292 0.237 NM_011740
Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr11_+_93857338 0.233 NM_027569
Spag9
sperm associated antigen 9
chr15_-_77949709 0.232 NM_007583
Cacng2
calcium channel, voltage-dependent, gamma subunit 2
chr8_+_85689250 0.232 NM_001111304
NM_027758
Tbc1d9

TBC1 domain family, member 9

chr2_-_52414072 0.226 NM_146123
Cacnb4
calcium channel, voltage-dependent, beta 4 subunit
chr10_+_110735734 0.221 NM_027914
Bbs10
Bardet-Biedl syndrome 10 (human)
chr5_-_139821054 0.221 NM_197980
Cox19
COX19 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr3_+_122432075 0.218 NM_153422
Pde5a
phosphodiesterase 5A, cGMP-specific
chr13_+_113450958 0.214 NM_178746
Slc38a9
solute carrier family 38, member 9
chr1_-_191511950 0.204 NM_001081363
Cenpf
centromere protein F
chr11_+_98902556 0.198 NM_010517
Igfbp4
insulin-like growth factor binding protein 4
chr4_-_125933482 0.197 NM_001145970
NM_144941
Mtap7d1

microtubule-associated protein 7 domain containing 1

chr18_-_7626805 0.194 NM_001081287
NM_001161620
Mpp7

membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)

chr4_-_87452140 0.194 NM_029931
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr15_+_59205752 0.192 NM_001164604
NM_026746
Nsmce2

non-SMC element 2 homolog (MMS21, S. cerevisiae)

chr13_+_107737175 0.192 NM_025447
Dimt1
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr4_-_87679175 0.192 NM_027326
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr6_+_140572056 0.184 NM_001005605
Aebp2
AE binding protein 2
chr12_-_80397239 0.180 NM_001008550
Zfyve26
zinc finger, FYVE domain containing 26
chr12_-_103995925 0.179 NM_001142938
NM_001142939
AK010878

cDNA sequence AK010878

chr16_+_31422377 0.179 NM_175177
Bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr14_+_31832323 0.174 NM_001081251
Pbrm1
polybromo 1
chr19_+_40969176 0.173 NM_028319
E130314M14Rik
Zfp518a
RIKEN cDNA E130314M14 gene
zinc finger protein 518A
chr6_-_28084368 0.173 NM_008174
Grm8
glutamate receptor, metabotropic 8
chr18_+_69505374 0.172 NM_001083967
Tcf4
transcription factor 4
chrX_+_97969784 0.171 NM_001177779
Dlg3
discs, large homolog 3 (Drosophila)
chr12_-_16596573 0.169 NM_001130412
NM_015763
NM_172950
Lpin1


lipin 1


chrX_-_9046362 0.163 NM_007807
Cybb
cytochrome b-245, beta polypeptide
chr7_+_97591287 0.161 NM_145151
Crebzf
CREB/ATF bZIP transcription factor
chr15_-_58765248 0.161 NM_175151
Tatdn1
TatD DNase domain containing 1
chr4_-_98484163 0.160 NM_172872
Kank4
KN motif and ankyrin repeat domains 4
chr7_+_94395160 0.158 NM_015760
Nox4
NADPH oxidase 4
chr14_+_8835385 0.157 NM_025341
Abhd6
abhydrolase domain containing 6
chr8_+_56040080 0.156 NM_153581
Gpm6a
glycoprotein m6a
chr14_+_29831283 0.148 NM_176920
Lrtm1
leucine-rich repeats and transmembrane domains 1
chr11_-_5442157 0.147 NM_134033
Ccdc117
coiled-coil domain containing 117
chr7_+_117365214 0.143 NM_009302
Swap70
SWA-70 protein
chr18_+_35721811 0.142 NM_010771
Matr3
matrin 3
chr4_-_118966945 0.142 NM_011732
Ybx1
Y box protein 1
chr14_+_67530044 0.138 NM_175498
Pnma2
paraneoplastic antigen MA2
chr7_+_26067197 0.137 NM_001110131
NM_001110132
NM_027882
Cic


capicua homolog (Drosophila)


chr16_+_29209780 0.134 NM_013751
Hrasls
HRAS-like suppressor
chr15_-_100382354 0.134 NM_033476
Tcfcp2
transcription factor CP2
chr4_+_24825226 0.134 NM_026742
Ndufaf4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr18_-_10029925 0.133 NM_001038589
NM_021522
Usp14

ubiquitin specific peptidase 14

chr8_-_8660610 0.131 NM_010111
Efnb2
ephrin B2
chr10_+_69559860 0.128 NM_001111121
Ccdc6
coiled-coil domain containing 6
chr15_-_100325669 0.127 NM_153407
Csrnp2
cysteine-serine-rich nuclear protein 2
chr7_+_98239230 0.125 NM_011807
Dlg2
discs, large homolog 2 (Drosophila)
chr5_+_136293975 0.125 NM_021403
Srrm3
serine/arginine repetitive matrix 3
chr17_-_57170896 0.123 NM_010613
Khsrp
KH-type splicing regulatory protein
chr4_-_110024513 0.123 NM_001163397
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
3.56 3.15e-03 GO:0006355 regulation of transcription, DNA-dependent
3.49 3.97e-03 GO:0051252 regulation of RNA metabolic process
3.27 8.43e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
4.55 1.12e-02 GO:0010604 positive regulation of macromolecule metabolic process
3.19 1.12e-02 GO:0010556 regulation of macromolecule biosynthetic process
4.46 1.31e-02 GO:0031325 positive regulation of cellular metabolic process
2.76 1.45e-02 GO:0060255 regulation of macromolecule metabolic process
3.09 1.60e-02 GO:0010468 regulation of gene expression
3.04 1.95e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.02 2.10e-02 GO:0031326 regulation of cellular biosynthetic process
3.01 2.19e-02 GO:0051171 regulation of nitrogen compound metabolic process
4.19 2.23e-02 GO:0009893 positive regulation of metabolic process
2.98 2.42e-02 GO:0009889 regulation of biosynthetic process
2.65 2.44e-02 GO:0031323 regulation of cellular metabolic process
5.22 3.04e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
4.91 4.66e-02 GO:0031328 positive regulation of cellular biosynthetic process

Gene overrepresentation in compartment category:

enrichment p-value GO term description
1.92 6.47e-04 GO:0043231 intracellular membrane-bounded organelle
1.92 6.76e-04 GO:0043227 membrane-bounded organelle
1.79 1.54e-03 GO:0043229 intracellular organelle
1.78 1.64e-03 GO:0043226 organelle
1.64 2.85e-03 GO:0044424 intracellular part
1.60 4.68e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment p-value GO term description
1.63 2.47e-03 GO:0005488 binding
3.61 5.61e-03 GO:0003677 DNA binding
2.93 9.34e-03 GO:0003676 nucleic acid binding