ISMARA results: BACH1_NFE2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for BACH1_NFE2_NFE2L2

Z-value: 4.19

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Transcription factors associated with BACH1_NFE2_NFE2L2

Gene Symbol	Gene ID	Gene Info
BACH1 Ensembl NCBI GeneCards UniProt	ENSG00000156273.11	BTB domain and CNC homolog 1
NFE2 Ensembl NCBI GeneCards UniProt	ENSG00000123405.9	nuclear factor, erythroid 2
NFE2L2 Ensembl NCBI GeneCards UniProt	ENSG00000116044.11	nuclear factor, erythroid 2 like 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFE2L2	hg19_v2_chr2_-_178128199_178128245	-0.66	1.5e-03	Click!
BACH1	hg19_v2_chr21_+_30671690_30671762	-0.66	1.6e-03	Click!
NFE2	hg19_v2_chr12_-_54694807_54694905	0.07	7.6e-01	Click!

Activity profile of BACH1_NFE2_NFE2L2 motif

Sorted Z-values of BACH1_NFE2_NFE2L2 motif

No targets for BACH1_NFE2_NFE2L2

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH1_NFE2_NFE2L2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	34.7	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.3	28.9	GO:0098869	cellular oxidant detoxification(GO:0098869)
0.4	19.7	GO:0019430	removal of superoxide radicals(GO:0019430)
0.0	18.0	GO:0000209	protein polyubiquitination(GO:0000209)
1.2	16.8	GO:0018298	protein-chromophore linkage(GO:0018298)
4.0	12.1	GO:0016107	sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488)
0.0	10.9	GO:0032259	methylation(GO:0032259)
1.1	10.7	GO:0034036	purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.6	10.6	GO:0038203	TORC2 signaling(GO:0038203)
0.8	10.5	GO:0001887	selenium compound metabolic process(GO:0001887)

Showing 1 to 10 of 177 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.9	GO:0072562	blood microparticle(GO:0072562)
1.4	16.7	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.6	15.4	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	12.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	11.7	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.4	10.6	GO:0031932	TORC2 complex(GO:0031932)
0.1	10.4	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	9.6	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.3	9.2	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.1	9.2	GO:0030173	integral component of Golgi membrane(GO:0030173)

Showing 1 to 10 of 83 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	22.1	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
4.4	17.5	GO:0004362	glutathione-disulfide reductase activity(GO:0004362)
0.6	17.1	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4	15.5	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
5.1	15.4	GO:0019862	IgA binding(GO:0019862)
3.1	15.4	GO:1990450	linear polyubiquitin binding(GO:1990450)
5.1	15.2	GO:0003955	NAD(P)H dehydrogenase (quinone) activity(GO:0003955)
0.1	13.2	GO:0019208	phosphatase regulator activity(GO:0019208)
4.0	12.1	GO:0045550	geranylgeranyl reductase activity(GO:0045550)
3.7	11.0	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)

Showing 1 to 10 of 137 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	22.7	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	18.2	PID TNF PATHWAY	TNF receptor signaling pathway
0.4	17.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	13.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	11.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	10.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	9.6	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	8.1	PID MTOR 4PATHWAY	mTOR signaling pathway
0.1	7.6	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.1	6.9	PID AURORA B PATHWAY	Aurora B signaling

Showing 1 to 10 of 37 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	34.8	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.8	33.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.8	15.4	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.2	14.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.2	13.7	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.4	11.9	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.4	8.5	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.5	7.7	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.1	7.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	6.7	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production

Showing 1 to 10 of 63 entries

Results for BACH1_NFE2_NFE2L2

Z-value: 4.19

Motif logo

Transcription factors associated with BACH1_NFE2_NFE2L2

Activity-expression correlation:

Activity profile of BACH1_NFE2_NFE2L2 motif

Sorted Z-values of BACH1_NFE2_NFE2L2 motif

No targets for BACH1_NFE2_NFE2L2

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH1_NFE2_NFE2L2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: