ISMARA results: DDIT3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DDIT3

Z-value: 1.51

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Transcription factors associated with DDIT3

Gene Symbol	Gene ID	Gene Info
DDIT3 Ensembl NCBI GeneCards UniProt	ENSG00000175197.6	DNA damage inducible transcript 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
DDIT3	hg19_v2_chr12_-_57914275_57914304	-0.41	7.4e-02	Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

No targets for DDIT3

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	4.7	GO:0001808	negative regulation of type IV hypersensitivity(GO:0001808)
0.0	4.1	GO:0008360	regulation of cell shape(GO:0008360)
0.0	3.7	GO:0048813	dendrite morphogenesis(GO:0048813)
0.3	3.6	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	2.7	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.1	2.6	GO:0000717	nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.1	2.6	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.6	2.3	GO:0006428	isoleucyl-tRNA aminoacylation(GO:0006428)
0.4	2.3	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.2	2.2	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)

Showing 1 to 10 of 53 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.2	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	2.7	GO:0045095	keratin filament(GO:0045095)
0.5	2.6	GO:0071942	XPC complex(GO:0071942)
0.1	2.3	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	2.3	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.3	2.2	GO:0097452	GAIT complex(GO:0097452)
0.1	2.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	1.9	GO:0031527	filopodium membrane(GO:0031527)
0.0	1.9	GO:0030175	filopodium(GO:0030175)
0.1	1.2	GO:0043083	synaptic cleft(GO:0043083)

Showing 1 to 10 of 24 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	4.7	GO:0042015	interleukin-20 binding(GO:0042015)
0.1	3.6	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	3.0	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	2.8	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	2.6	GO:0031593	polyubiquitin binding(GO:0031593)
0.6	2.3	GO:0004822	isoleucine-tRNA ligase activity(GO:0004822)
0.2	2.3	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.1	2.2	GO:0008143	poly(A) binding(GO:0008143)
0.1	2.1	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1	2.0	GO:0008494	translation activator activity(GO:0008494)

Showing 1 to 10 of 42 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
3.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.3	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
2.3	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
1.9	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.1	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
1.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Showing 1 to 7 of 7 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	2.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	2.3	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1	2.1	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.1	1.4	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	1.4	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	1.0	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	1.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.9	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC

Showing 1 to 10 of 18 entries

Results for DDIT3

Z-value: 1.51

Motif logo

Transcription factors associated with DDIT3

Activity-expression correlation:

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

No targets for DDIT3

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: