ISMARA results: FOXD1_FOXO1_FOXO6_FOXG1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Z-value: 1.92

Motif logo

Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Gene Symbol	Gene ID	Gene Info
FOXD1 Ensembl NCBI GeneCards UniProt	ENSG00000251493.2	forkhead box D1
FOXO1 Ensembl NCBI GeneCards UniProt	ENSG00000150907.6	forkhead box O1
FOXO6 Ensembl NCBI GeneCards UniProt	ENSG00000204060.4	forkhead box O6
FOXG1 Ensembl NCBI GeneCards UniProt	ENSG00000176165.7	forkhead box G1
FOXP1 Ensembl NCBI GeneCards UniProt	ENSG00000114861.14	forkhead box P1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXP1	hg19_v2_chr3_-_71114066_71114114	0.90	8.5e-08	Click!
FOXO1	hg19_v2_chr13_-_41240717_41240735	0.74	1.9e-04	Click!
FOXO6	hg19_v2_chr1_+_41827594_41827594	-0.70	5.3e-04	Click!
FOXG1	hg19_v2_chr14_+_29234870_29235050	0.12	6.2e-01	Click!
FOXD1	hg19_v2_chr5_-_72744336_72744359	-0.01	9.8e-01	Click!

Activity profile of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif

Sorted Z-values of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif

No targets for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	13.7	GO:0090179	planar cell polarity pathway involved in neural tube closure(GO:0090179)
1.9	11.4	GO:0032625	interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.3	10.1	GO:0032060	bleb assembly(GO:0032060)
1.8	9.2	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.8	9.2	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.3	8.6	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592)
1.1	8.0	GO:0072675	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.6	7.9	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
1.0	7.8	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.2	7.6	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)

Showing 1 to 10 of 304 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	9.6	GO:0030478	actin cap(GO:0030478)
0.5	8.5	GO:0031209	SCAR complex(GO:0031209)
0.8	7.9	GO:0000798	nuclear cohesin complex(GO:0000798)
0.1	7.6	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2	7.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	6.3	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	6.0	GO:0005795	Golgi stack(GO:0005795)
1.0	5.8	GO:0031673	H zone(GO:0031673)
0.0	5.6	GO:0005905	clathrin-coated pit(GO:0005905)
0.2	5.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)

Showing 1 to 10 of 136 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	17.9	GO:0070888	E-box binding(GO:0070888)
0.1	15.3	GO:0031490	chromatin DNA binding(GO:0031490)
0.2	14.5	GO:0050681	androgen receptor binding(GO:0050681)
0.0	14.1	GO:0045296	cadherin binding(GO:0045296)
0.2	10.8	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	9.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	9.6	GO:0005523	tropomyosin binding(GO:0005523)
3.1	9.2	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.7	9.2	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1	8.7	GO:0001786	phosphatidylserine binding(GO:0001786)

Showing 1 to 10 of 200 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	21.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	11.8	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	11.8	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	11.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	11.4	PID MYC PATHWAY	C-MYC pathway
0.1	7.6	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.2	7.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	4.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	4.9	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	4.2	PID TGFBR PATHWAY	TGF-beta receptor signaling

Showing 1 to 10 of 47 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.1	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.1	9.9	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	7.5	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3	7.0	REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	Genes involved in Activation of Chaperones by ATF6-alpha
0.1	6.8	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	6.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	6.5	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	6.2	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	6.1	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.2	5.8	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)

Showing 1 to 10 of 72 entries

Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Z-value: 1.92

Motif logo

Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Activity-expression correlation:

Activity profile of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif

Sorted Z-values of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif

No targets for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: