ISMARA results: FOXM1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXM1_TBL1XR1

Z-value: 6.17

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Transcription factors associated with FOXM1_TBL1XR1

Gene Symbol	Gene ID	Gene Info
FOXM1 Ensembl NCBI GeneCards UniProt	ENSG00000111206.8	forkhead box M1
TBL1XR1 Ensembl NCBI GeneCards UniProt	ENSG00000177565.11	TBL1X receptor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXM1	hg19_v2_chr12_-_2986107_2986258	-0.91	1.7e-08	Click!
TBL1XR1	hg19_v2_chr3_-_176914238_176914277	0.75	1.3e-04	Click!

Activity profile of FOXM1_TBL1XR1 motif

Sorted Z-values of FOXM1_TBL1XR1 motif

No targets for FOXM1_TBL1XR1

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXM1_TBL1XR1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	92.2	GO:0031581	hemidesmosome assembly(GO:0031581)
1.0	67.7	GO:0018149	peptide cross-linking(GO:0018149)
10.6	63.8	GO:0002225	positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.9	44.7	GO:0060216	definitive hemopoiesis(GO:0060216)
2.5	44.4	GO:0015816	glycine transport(GO:0015816)
9.7	38.9	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
1.9	36.7	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.7	34.3	GO:0032732	positive regulation of interleukin-1 production(GO:0032732)
0.7	34.0	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
1.7	33.2	GO:0016540	protein autoprocessing(GO:0016540)

Showing 1 to 10 of 1,299 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	112.3	GO:0001533	cornified envelope(GO:0001533)
10.5	73.3	GO:0097209	epidermal lamellar body(GO:0097209)
0.1	56.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
6.8	47.3	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
1.7	45.4	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.3	45.3	GO:0005796	Golgi lumen(GO:0005796)
0.4	40.7	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.4	40.1	GO:0035577	azurophil granule membrane(GO:0035577)
3.1	34.5	GO:0005610	laminin-5 complex(GO:0005610)
0.4	33.0	GO:0045095	keratin filament(GO:0045095)

Showing 1 to 10 of 433 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	215.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	166.0	GO:0003700	transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.0	150.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	70.9	GO:0060090	binding, bridging(GO:0060090)
0.5	46.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	46.9	GO:0050839	cell adhesion molecule binding(GO:0050839)
3.0	45.0	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
2.4	38.7	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.1	38.1	GO:0032561	guanyl ribonucleotide binding(GO:0032561)
2.0	34.4	GO:0032395	MHC class II receptor activity(GO:0032395)

Showing 1 to 10 of 731 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	201.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9	99.8	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.2	61.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.8	59.9	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.5	55.4	PID NOTCH PATHWAY	Notch signaling pathway
1.1	42.5	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
1.3	36.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.7	33.4	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.7	31.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.7	30.3	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events

Showing 1 to 10 of 109 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	113.8	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.5	62.7	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
1.1	45.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
2.1	44.7	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.5	33.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.6	31.0	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
1.2	28.3	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
1.3	20.4	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.1	19.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.7	18.7	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly

Showing 1 to 10 of 145 entries

Results for FOXM1_TBL1XR1

Z-value: 6.17

Motif logo

Transcription factors associated with FOXM1_TBL1XR1

Activity-expression correlation:

Activity profile of FOXM1_TBL1XR1 motif

Sorted Z-values of FOXM1_TBL1XR1 motif

No targets for FOXM1_TBL1XR1

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXM1_TBL1XR1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: