ISMARA results: GSC

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GSC_GSC2

Z-value: 1.11

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Transcription factors associated with GSC_GSC2

Gene Symbol	Gene ID	Gene Info
GSC Ensembl NCBI GeneCards UniProt	ENSG00000133937.3	goosecoid homeobox
GSC2 Ensembl NCBI GeneCards UniProt	ENSG00000063515.2	goosecoid homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GSC	hg19_v2_chr14_-_95236551_95236576	0.69	8.1e-04	Click!
GSC2	hg19_v2_chr22_-_19137796_19137796	-0.23	3.2e-01	Click!

Activity profile of GSC_GSC2 motif

Sorted Z-values of GSC_GSC2 motif

No targets for GSC_GSC2

Network of associatons between targets according to the STRING database.

First level regulatory network of GSC_GSC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.0	GO:0006081	cellular aldehyde metabolic process(GO:0006081)
0.3	3.1	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.1	2.5	GO:0071420	cellular response to histamine(GO:0071420)
0.0	2.3	GO:0071353	cellular response to interleukin-4(GO:0071353)
0.1	2.0	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	1.9	GO:0008045	motor neuron axon guidance(GO:0008045)
0.3	1.7	GO:0036343	psychomotor behavior(GO:0036343)
0.1	1.7	GO:0051256	mitotic spindle midzone assembly(GO:0051256)
0.1	1.6	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.5	1.5	GO:0043311	regulation of eosinophil degranulation(GO:0043309) positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)

Showing 1 to 10 of 64 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.3	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.1	2.5	GO:1902711	GABA-A receptor complex(GO:1902711)
0.0	2.4	GO:0045171	intercellular bridge(GO:0045171)
0.1	1.7	GO:0034709	methylosome(GO:0034709)
0.1	1.5	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	1.5	GO:0031143	pseudopodium(GO:0031143)
0.0	1.5	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	1.4	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.1	1.3	GO:0055028	cortical microtubule(GO:0055028)
0.0	1.2	GO:0001917	photoreceptor inner segment(GO:0001917)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.4	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	3.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	2.5	GO:0022851	GABA-gated chloride ion channel activity(GO:0022851)
0.0	2.0	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	1.9	GO:0046875	ephrin receptor binding(GO:0046875)
0.2	1.7	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	1.7	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3	1.5	GO:0098625	methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.3	1.5	GO:1990450	linear polyubiquitin binding(GO:1990450)
0.2	1.5	GO:0015057	thrombin receptor activity(GO:0015057)

Showing 1 to 10 of 44 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	2.3	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	1.8	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.5	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	1.3	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.8	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.4	PID CONE PATHWAY	Visual signal transduction: Cones

Showing 1 to 8 of 8 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	2.3	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	1.9	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0	1.7	REACTOME KINESINS	Genes involved in Kinesins
0.1	1.5	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	1.5	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	1.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	1.3	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	1.3	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.1	1.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation

Showing 1 to 10 of 17 entries

Results for GSC_GSC2

Z-value: 1.11

Motif logo

Transcription factors associated with GSC_GSC2

Activity-expression correlation:

Activity profile of GSC_GSC2 motif

Sorted Z-values of GSC_GSC2 motif

No targets for GSC_GSC2

Network of associatons between targets according to the STRING database.

First level regulatory network of GSC_GSC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: