ISMARA results: HOXD11

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXD11_HOXA11

Z-value: 0.61

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Transcription factors associated with HOXD11_HOXA11

Gene Symbol	Gene ID	Gene Info
HOXD11 Ensembl NCBI GeneCards UniProt	ENSG00000128713.11	homeobox D11
HOXA11 Ensembl NCBI GeneCards UniProt	ENSG00000005073.5	homeobox A11

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXA11	hg19_v2_chr7_-_27224795_27224840	0.31	1.8e-01	Click!
HOXD11	hg19_v2_chr2_+_176972000_176972025	0.06	8.2e-01	Click!

Activity profile of HOXD11_HOXA11 motif

Sorted Z-values of HOXD11_HOXA11 motif

No targets for HOXD11_HOXA11

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD11_HOXA11

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	GO:0042246	tissue regeneration(GO:0042246)
0.2	1.9	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.0	1.7	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.4	1.6	GO:0060585	nitric oxide transport(GO:0030185) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1	1.5	GO:0035493	SNARE complex assembly(GO:0035493)
0.1	1.4	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	1.4	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.4	1.2	GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.4	1.2	GO:0007412	axon target recognition(GO:0007412)
0.4	1.1	GO:2000830	vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)

Showing 1 to 10 of 180 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	GO:0044306	neuron projection terminus(GO:0044306)
0.4	1.6	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.0	1.5	GO:0035580	specific granule lumen(GO:0035580)
0.3	1.0	GO:1990423	RZZ complex(GO:1990423)
0.1	1.0	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	1.0	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.9	GO:0000786	nucleosome(GO:0000786)
0.1	0.8	GO:0005579	membrane attack complex(GO:0005579)
0.2	0.7	GO:0042720	mitochondrial inner membrane peptidase complex(GO:0042720)
0.1	0.7	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)

Showing 1 to 10 of 54 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	GO:0098531	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1	1.7	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.3	1.6	GO:0031708	endothelin B receptor binding(GO:0031708)
0.1	1.4	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	1.3	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	1.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.4	1.2	GO:0016603	glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.3	1.2	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.1	1.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	1.1	GO:0008061	chitin binding(GO:0008061)

Showing 1 to 10 of 117 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.9	PID ENDOTHELIN PATHWAY	Endothelins
1.4	PID GLYPICAN 1PATHWAY	Glypican 1 network
1.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.7	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.5	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.5	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.4	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5

Showing 1 to 10 of 13 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	1.7	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	1.7	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.5	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	1.5	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	1.4	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	1.0	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.1	1.0	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.9	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.8	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters

Showing 1 to 10 of 27 entries

Results for HOXD11_HOXA11

Z-value: 0.61

Motif logo

Transcription factors associated with HOXD11_HOXA11

Activity-expression correlation:

Activity profile of HOXD11_HOXA11 motif

Sorted Z-values of HOXD11_HOXA11 motif

No targets for HOXD11_HOXA11

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD11_HOXA11

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: