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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for LHX2

Z-value: 0.41

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Transcription factors associated with LHX2

Gene Symbol Gene ID Gene Info
ENSG00000106689.6 LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX2hg19_v2_chr9_+_126777676_126777700-0.292.1e-01Click!

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.2 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.1 0.3 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.0 0.1 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.2 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.2 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.3 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.1 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.0 0.2 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.2 GO:1903284 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.6 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.2 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.0 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:1902912 pyruvate kinase complex(GO:1902912)
0.0 0.2 GO:1990812 growth cone filopodium(GO:1990812)
0.0 0.6 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0032010 phagolysosome(GO:0032010)
0.0 0.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558) protease inhibitor complex(GO:0097179)
0.0 0.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.1 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.0 0.2 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.1 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.1 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.0 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome