ISMARA results: NKX2-8

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-8

Z-value: 0.46

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Transcription factors associated with NKX2-8

Gene Symbol	Gene ID	Gene Info
NKX2-8 Ensembl NCBI GeneCards UniProt	ENSG00000136327.6	NK2 homeobox 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX2-8	hg19_v2_chr14_-_37051798_37051831	-0.69	8.1e-04	Click!

Activity profile of NKX2-8 motif

Sorted Z-values of NKX2-8 motif

No targets for NKX2-8

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	GO:0032060	bleb assembly(GO:0032060)
0.2	1.3	GO:0043163	cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1	1.0	GO:1900625	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3	0.8	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.2	0.7	GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2	0.7	GO:0003131	mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.1	0.5	GO:0042335	cuticle development(GO:0042335)
0.0	0.5	GO:0034770	histone H4-K20 methylation(GO:0034770)
0.0	0.5	GO:1903846	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.5	GO:0030488	tRNA methylation(GO:0030488)

Showing 1 to 10 of 60 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0001533	cornified envelope(GO:0001533)
0.1	1.0	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0	0.8	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.8	GO:0043034	costamere(GO:0043034)
0.1	0.7	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
0.1	0.7	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	0.4	GO:0032144	4-aminobutyrate transaminase complex(GO:0032144)
0.0	0.4	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.4	GO:0043209	myelin sheath(GO:0043209)
0.1	0.3	GO:0044611	nuclear pore inner ring(GO:0044611)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	1.0	GO:0005540	hyaluronic acid binding(GO:0005540)
0.2	0.7	GO:0035501	MH1 domain binding(GO:0035501)
0.0	0.7	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.0	0.7	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.1	0.6	GO:0009019	tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0	0.6	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.5	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.5	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.1	0.4	GO:0003867	4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.8	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.8	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.5	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.3	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling

Showing 1 to 5 of 5 entries

Results for NKX2-8

Z-value: 0.46

Motif logo

Transcription factors associated with NKX2-8

Activity-expression correlation:

Activity profile of NKX2-8 motif

Sorted Z-values of NKX2-8 motif

No targets for NKX2-8

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: