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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU6F1

Z-value: 0.75

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
ENSG00000184271.11 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg19_v2_chr12_-_51611477_51611612-0.492.8e-02Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.4 GO:1902024 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.7 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 0.6 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.2 GO:0007387 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.1 0.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.7 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.6 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.5 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 1.2 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.6 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.6 GO:0016180 snRNA processing(GO:0016180)
0.0 0.3 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.4 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.3 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.3 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.1 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071001 U4/U6 snRNP(GO:0071001)
0.1 0.6 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.8 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.1 0.6 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 1.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.4 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.0 0.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.3 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.7 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.8 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.0 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC