ISMARA results: REST

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for REST

Z-value: 3.27

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Transcription factors associated with REST

Gene Symbol	Gene ID	Gene Info
REST Ensembl NCBI GeneCards UniProt	ENSG00000084093.11	RE1 silencing transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
REST	hg19_v2_chr4_+_57774042_57774114	-0.86	1.1e-06	Click!

Activity profile of REST motif

Sorted Z-values of REST motif

No targets for REST

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	32.6	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.0	18.9	GO:0043687	post-translational protein modification(GO:0043687)
2.3	9.1	GO:0035483	gastric motility(GO:0035482) gastric emptying(GO:0035483)
0.0	8.7	GO:0001837	epithelial to mesenchymal transition(GO:0001837)
0.1	7.9	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.2	7.5	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)
1.2	7.2	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	7.2	GO:0070268	cornification(GO:0070268)
0.9	6.4	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
1.0	5.8	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)

Showing 1 to 10 of 60 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	32.6	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0	22.1	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	9.2	GO:0008021	synaptic vesicle(GO:0008021)
1.1	9.1	GO:0043196	varicosity(GO:0043196)
0.1	7.7	GO:0031201	SNARE complex(GO:0031201)
0.9	7.2	GO:0005579	membrane attack complex(GO:0005579)
0.1	7.2	GO:0045095	keratin filament(GO:0045095)
0.8	5.8	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.2	4.4	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2	4.2	GO:0042583	chromaffin granule(GO:0042583)

Showing 1 to 10 of 36 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	34.8	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	25.6	GO:0005179	hormone activity(GO:0005179)
3.0	9.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.4	8.7	GO:0050786	RAGE receptor binding(GO:0050786)
0.2	7.0	GO:0008009	chemokine activity(GO:0008009)
0.0	6.0	GO:0000149	SNARE binding(GO:0000149)
0.7	5.8	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0	5.3	GO:0016651	oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.1	4.4	GO:0042169	SH2 domain binding(GO:0042169)
0.6	3.9	GO:0044736	acid-sensing ion channel activity(GO:0044736)

Showing 1 to 10 of 44 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	2.0	ST STAT3 PATHWAY	STAT3 Pathway
0.0	2.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	1.6	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	1.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.1	PID FANCONI PATHWAY	Fanconi anemia pathway

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.2	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	5.8	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	5.3	REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.1	5.0	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	4.1	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	3.9	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	3.8	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	3.0	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	2.5	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
0.0	2.1	REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	Genes involved in NCAM signaling for neurite out-growth

Showing 1 to 10 of 21 entries

Results for REST

Z-value: 3.27

Motif logo

Transcription factors associated with REST

Activity-expression correlation:

Activity profile of REST motif

Sorted Z-values of REST motif

No targets for REST

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: