Project
avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for REST
Z-value: 3.27
Motif logo
Transcription factors associated with REST
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
REST
|
ENSG00000084093.11 | RE1 silencing transcription factor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| REST | hg19_v2_chr4_+_57774042_57774114 | -0.86 | 1.1e-06 | Click! |
Activity profile of REST motif
Sorted Z-values of REST motif
Network of associatons between targets according to the STRING database.
First level regulatory network of REST
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 9.1 | GO:0035483 | gastric motility(GO:0035482) gastric emptying(GO:0035483) |
| 1.4 | 4.2 | GO:1900738 | dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705) |
| 1.2 | 7.2 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 1.2 | 32.6 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 1.0 | 3.0 | GO:2000824 | negative regulation of androgen receptor activity(GO:2000824) |
| 1.0 | 5.8 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 1.0 | 3.9 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 0.9 | 6.4 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
| 0.8 | 3.9 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.8 | 3.0 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.5 | 2.0 | GO:0071393 | cellular response to progesterone stimulus(GO:0071393) |
| 0.5 | 0.5 | GO:0032097 | positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100) |
| 0.5 | 1.4 | GO:1990258 | box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258) |
| 0.4 | 4.4 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.4 | 3.9 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.4 | 1.1 | GO:2000974 | auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974) |
| 0.4 | 1.1 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) |
| 0.4 | 2.2 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.3 | 2.3 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
| 0.3 | 0.6 | GO:0003192 | mitral valve formation(GO:0003192) |
| 0.3 | 2.6 | GO:0032099 | negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) |
| 0.2 | 4.4 | GO:0048149 | behavioral response to ethanol(GO:0048149) |
| 0.2 | 2.9 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.2 | 2.1 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.2 | 1.7 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.2 | 7.5 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.2 | 3.8 | GO:0034776 | response to histamine(GO:0034776) cellular response to histamine(GO:0071420) |
| 0.2 | 1.3 | GO:1902075 | cellular response to salt(GO:1902075) |
| 0.2 | 1.6 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.1 | 2.1 | GO:0032782 | bile acid secretion(GO:0032782) |
| 0.1 | 2.0 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 0.4 | GO:0040040 | thermosensory behavior(GO:0040040) |
| 0.1 | 0.3 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.1 | 4.1 | GO:0002021 | response to dietary excess(GO:0002021) |
| 0.1 | 0.8 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 3.3 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.1 | 0.9 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.1 | 1.1 | GO:0090385 | phagosome-lysosome fusion(GO:0090385) |
| 0.1 | 7.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.1 | 3.1 | GO:0030033 | microvillus assembly(GO:0030033) |
| 0.1 | 1.0 | GO:0010917 | negative regulation of mitochondrial membrane potential(GO:0010917) |
| 0.1 | 4.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 0.5 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
| 0.1 | 5.3 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 7.2 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 2.4 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 0.8 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 1.7 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 0.2 | GO:0048165 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.0 | 0.7 | GO:0030575 | nuclear body organization(GO:0030575) |
| 0.0 | 8.7 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.0 | 2.5 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 18.9 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.0 | 0.4 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 1.1 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.4 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 1.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.2 | GO:0010578 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) |
| 0.0 | 0.2 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
| 0.0 | 0.4 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 32.6 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 1.1 | 9.1 | GO:0043196 | varicosity(GO:0043196) |
| 0.9 | 7.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.8 | 5.8 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.5 | 2.2 | GO:0032127 | dense core granule membrane(GO:0032127) microvesicle(GO:1990742) |
| 0.4 | 2.5 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.3 | 0.9 | GO:0016935 | glycine-gated chloride channel complex(GO:0016935) |
| 0.2 | 2.1 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.2 | 4.4 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 1.4 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.2 | 1.6 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.2 | 2.0 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.2 | 4.2 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.2 | 2.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 2.9 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.1 | 1.7 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.1 | 3.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 7.7 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 1.3 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 7.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 1.1 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 0.3 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.1 | 3.1 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 1.1 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 22.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 9.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.0 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 3.3 | GO:0030658 | transport vesicle membrane(GO:0030658) |
| 0.0 | 3.8 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.0 | 0.2 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 1.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 1.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.1 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 9.1 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 1.0 | 3.0 | GO:0004781 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.7 | 3.0 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.7 | 5.8 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.6 | 3.9 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.6 | 34.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.5 | 1.4 | GO:0036009 | protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259) |
| 0.4 | 1.6 | GO:0015173 | aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.4 | 8.7 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.3 | 3.8 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.2 | 1.7 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.2 | 25.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.2 | 2.0 | GO:0071253 | connexin binding(GO:0071253) |
| 0.2 | 7.0 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.2 | 3.2 | GO:0008430 | selenium binding(GO:0008430) inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.2 | 0.8 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.1 | 2.0 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 0.8 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.1 | 1.7 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 1.6 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 0.5 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.1 | 2.9 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 0.8 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 4.4 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 0.7 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.1 | 2.3 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 1.1 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 2.1 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 6.0 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 1.1 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.4 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 0.3 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 5.3 | GO:0016651 | oxidoreductase activity, acting on NAD(P)H(GO:0016651) |
| 0.0 | 3.8 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.4 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 1.4 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.2 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 2.6 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 3.3 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 3.1 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.5 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 2.0 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 8.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.8 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 7.2 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 3.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 5.0 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.1 | 3.0 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 2.0 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 0.8 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.1 | 1.1 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 0.8 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.5 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 4.1 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.6 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 1.0 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 5.3 | REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| 0.0 | 0.5 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 0.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 2.1 | REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | Genes involved in NCAM signaling for neurite out-growth |
| 0.0 | 2.5 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.0 | 3.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.2 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |