ISMARA results: SMAD2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SMAD2

Z-value: 0.64

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Transcription factors associated with SMAD2

Gene Symbol	Gene ID	Gene Info
SMAD2 Ensembl NCBI GeneCards UniProt	ENSG00000175387.11	SMAD family member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SMAD2	hg19_v2_chr18_-_45456693_45456733	0.29	2.2e-01	Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

No targets for SMAD2

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0061536	glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0	0.6	GO:0032836	glomerular basement membrane development(GO:0032836)
0.1	0.5	GO:0048687	modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0	0.5	GO:0032060	bleb assembly(GO:0032060)
0.0	0.4	GO:0072144	glomerular mesangial cell development(GO:0072144)
0.0	0.4	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.1	0.3	GO:0060738	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.1	0.3	GO:0070843	misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1	0.3	GO:1905073	occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.0	0.3	GO:0038203	TORC2 signaling(GO:0038203)

Showing 1 to 10 of 41 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.5	GO:0043218	compact myelin(GO:0043218)
0.0	0.4	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.3	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0070436	Grb2-EGFR complex(GO:0070436)
0.0	0.2	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0070931	Golgi-associated vesicle lumen(GO:0070931)
0.0	0.1	GO:0045160	myosin I complex(GO:0045160)
0.0	0.1	GO:0097135	cyclin E2-CDK2 complex(GO:0097135)

Showing 1 to 10 of 11 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.2	0.7	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.5	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.3	GO:0042903	tubulin deacetylase activity(GO:0042903)
0.0	0.3	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.3	GO:0005114	transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114)
0.1	0.2	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.0	0.2	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.2	GO:0008481	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)

Showing 1 to 10 of 19 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters

Showing 1 to 1 of 1 entries

Results for SMAD2

Z-value: 0.64

Motif logo

Transcription factors associated with SMAD2

Activity-expression correlation:

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

No targets for SMAD2

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category: