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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPI1

Z-value: 1.91

Motif logo

Transcription factors associated with SPI1

Gene Symbol Gene ID Gene Info
ENSG00000066336.7 Spi-1 proto-oncogene

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPI1hg19_v2_chr11_-_47400062_47400077-0.521.8e-02Click!

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.4 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
1.6 4.7 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.5 10.6 GO:0071461 cellular response to redox state(GO:0071461)
1.2 3.7 GO:1902362 melanocyte apoptotic process(GO:1902362)
1.0 3.0 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.9 4.7 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.9 2.8 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
0.9 4.4 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.9 9.6 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.8 9.7 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.7 2.9 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.7 2.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.6 5.6 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.6 2.4 GO:0030223 neutrophil differentiation(GO:0030223)
0.6 1.7 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.5 6.0 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.5 2.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.5 4.1 GO:0032485 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.5 5.1 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.5 4.1 GO:0030578 PML body organization(GO:0030578)
0.5 1.5 GO:0060086 circadian temperature homeostasis(GO:0060086)
0.5 2.0 GO:0009956 radial pattern formation(GO:0009956)
0.5 1.0 GO:0042730 fibrinolysis(GO:0042730)
0.5 2.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.5 0.5 GO:0043506 regulation of JUN kinase activity(GO:0043506) positive regulation of JUN kinase activity(GO:0043507)
0.5 2.8 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.5 1.4 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.4 2.6 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.4 3.9 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.4 1.3 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.4 1.2 GO:0003273 chronological cell aging(GO:0001300) cell migration involved in endocardial cushion formation(GO:0003273)
0.4 1.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.4 2.1 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.3 1.0 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.3 0.3 GO:0030225 macrophage differentiation(GO:0030225)
0.3 1.0 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.3 0.6 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
0.3 1.0 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) positive regulation of translational initiation by iron(GO:0045994)
0.3 2.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.3 0.6 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.3 2.1 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.3 3.0 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.3 4.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 1.2 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.3 0.9 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.3 0.8 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.3 2.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.3 6.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 4.0 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.3 1.6 GO:0001692 histamine metabolic process(GO:0001692)
0.3 1.0 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092)
0.2 4.2 GO:0033623 regulation of integrin activation(GO:0033623)
0.2 1.5 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.2 2.4 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2 0.9 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.2 1.6 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.2 1.1 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.2 4.0 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 3.5 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 0.8 GO:1900154 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.2 0.8 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 1.0 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.2 1.4 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.2 0.8 GO:0044010 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.2 0.6 GO:0071109 superior temporal gyrus development(GO:0071109)
0.2 1.2 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 4.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.2 1.3 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 0.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.2 1.6 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.2 0.5 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.2 3.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 1.7 GO:1903365 regulation of fear response(GO:1903365) regulation of behavioral fear response(GO:2000822)
0.2 4.9 GO:0035855 megakaryocyte development(GO:0035855)
0.2 1.3 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.2 0.7 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.2 1.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.2 1.9 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 4.1 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.2 0.5 GO:0042704 detection of oxygen(GO:0003032) uterine wall breakdown(GO:0042704)
0.2 1.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.2 0.6 GO:1902304 phosphatidylserine exposure on blood platelet(GO:0097045) positive regulation of potassium ion export(GO:1902304)
0.2 1.7 GO:0050890 cognition(GO:0050890)
0.2 2.0 GO:0032596 protein transport into membrane raft(GO:0032596)
0.1 0.6 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.1 0.6 GO:0060809 cardiac right atrium morphogenesis(GO:0003213) chemoattraction of serotonergic neuron axon(GO:0036517) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) mesodermal to mesenchymal transition involved in gastrulation(GO:0060809) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) chemoattraction of axon(GO:0061642) negative regulation of cell proliferation in midbrain(GO:1904934) planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation(GO:1904955)
0.1 0.6 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.1 0.3 GO:0010966 regulation of phosphate transport(GO:0010966)
0.1 0.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.9 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.5 GO:0050821 protein stabilization(GO:0050821)
0.1 2.1 GO:0070970 interleukin-2 secretion(GO:0070970)
0.1 4.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.4 GO:0003250 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250)
0.1 0.7 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.9 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 2.2 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 0.4 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.1 0.7 GO:0007296 vitellogenesis(GO:0007296)
0.1 1.6 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 0.2 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685)
0.1 1.1 GO:0001714 endodermal cell fate specification(GO:0001714)
0.1 0.8 GO:0006226 dUMP biosynthetic process(GO:0006226)
0.1 0.7 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.1 1.8 GO:0090050 peptidyl-lysine deacetylation(GO:0034983) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.5 GO:1904693 midbrain morphogenesis(GO:1904693)
0.1 0.3 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.1 0.8 GO:0048478 replication fork protection(GO:0048478)
0.1 0.8 GO:0032439 endosome localization(GO:0032439)
0.1 4.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.9 GO:1901166 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.1 0.4 GO:0001928 regulation of exocyst assembly(GO:0001928) regulation of exocyst localization(GO:0060178)
0.1 1.5 GO:0060613 fat pad development(GO:0060613)
0.1 0.4 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 0.3 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.1 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.1 1.0 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 1.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.4 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.2 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.3 GO:0061485 memory T cell proliferation(GO:0061485)
0.1 1.5 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 0.5 GO:0072752 cellular response to rapamycin(GO:0072752)
0.1 0.5 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 2.1 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 1.9 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 4.7 GO:0042554 superoxide anion generation(GO:0042554)
0.1 3.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.6 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 2.1 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 0.6 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.1 0.4 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 1.3 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.2 GO:0030220 platelet formation(GO:0030220)
0.1 0.6 GO:1901295 regulation of Wnt signaling pathway involved in heart development(GO:0003307) arterial endothelial cell fate commitment(GO:0060844) positive regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061419) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 2.3 GO:0002347 response to tumor cell(GO:0002347)
0.1 0.2 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008)
0.1 1.0 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 0.2 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1 0.6 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1 1.0 GO:0010815 bradykinin catabolic process(GO:0010815)
0.1 0.5 GO:0097475 motor neuron migration(GO:0097475)
0.1 1.0 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.9 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 0.6 GO:0080009 mRNA methylation(GO:0080009)
0.1 5.7 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 0.6 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.1 0.4 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 0.3 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.1 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.1 0.7 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 0.2 GO:0002879 leukocyte chemotaxis involved in inflammatory response(GO:0002232) positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.1 1.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 0.4 GO:0045995 regulation of embryonic development(GO:0045995)
0.1 0.5 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.1 0.4 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1 2.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.8 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.3 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.1 0.2 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.2 GO:1905053 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.1 0.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.4 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.1 2.9 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 3.2 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.1 1.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 0.2 GO:0019085 early viral transcription(GO:0019085)
0.1 0.4 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.1 0.7 GO:0097012 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.1 1.6 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 0.2 GO:1990637 response to prolactin(GO:1990637)
0.1 1.5 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.2 GO:0002678 positive regulation of chronic inflammatory response(GO:0002678)
0.1 0.2 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
0.1 1.4 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.1 0.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 0.5 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 0.4 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.9 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 0.1 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.1 0.7 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 0.2 GO:0035509 negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 11.4 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.1 0.4 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.1 1.2 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 0.6 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 0.3 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 1.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 2.0 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 1.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.2 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 1.4 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 3.6 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.4 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.4 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.2 GO:0021779 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 1.4 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.4 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.0 1.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.7 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 0.9 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.5 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 1.2 GO:0036065 fucosylation(GO:0036065)
0.0 0.3 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 1.2 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.2 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 1.8 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 0.2 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 1.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.9 GO:0006020 inositol metabolic process(GO:0006020)
0.0 1.1 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.5 GO:0046885 regulation of hormone biosynthetic process(GO:0046885)
0.0 0.7 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.7 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.0 0.2 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.0 0.6 GO:1903350 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.0 0.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.8 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.4 GO:1902902 positive regulation of autophagosome maturation(GO:1901098) negative regulation of autophagosome assembly(GO:1902902)
0.0 0.3 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.7 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.9 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.9 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.3 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.7 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.2 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.1 GO:0097051 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.5 GO:0070997 neuron death(GO:0070997)
0.0 0.1 GO:0061056 sclerotome development(GO:0061056)
0.0 1.9 GO:0055078 sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.0 0.1 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.0 0.2 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.5 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.0 0.5 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 3.3 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.1 GO:0048290 isotype switching to IgA isotypes(GO:0048290)
0.0 0.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 1.6 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.3 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.2 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.1 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0 0.6 GO:0045116 protein neddylation(GO:0045116)
0.0 0.2 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.3 GO:0015825 L-serine transport(GO:0015825)
0.0 0.2 GO:0019336 phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.0 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 1.2 GO:0021762 substantia nigra development(GO:0021762)
0.0 0.2 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.9 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:0042737 drug catabolic process(GO:0042737)
0.0 2.3 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.1 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.1 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110) cellular response to interleukin-2(GO:0071352)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.8 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.6 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) innate vocalization behavior(GO:0098582)
0.0 0.0 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 2.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.8 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.3 GO:0051149 positive regulation of muscle cell differentiation(GO:0051149)
0.0 2.0 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.9 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0038111 interleukin-7-mediated signaling pathway(GO:0038111) response to interleukin-7(GO:0098760) cellular response to interleukin-7(GO:0098761)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 2.6 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 1.5 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.5 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.5 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.0 0.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.3 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.0 2.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.5 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 0.3 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.3 GO:0051583 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.9 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.1 GO:0046108 uridine metabolic process(GO:0046108)
0.0 0.1 GO:0023035 CD40 signaling pathway(GO:0023035)
0.0 0.9 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 1.0 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.2 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 1.0 GO:0032259 methylation(GO:0032259)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 0.4 GO:0032460 negative regulation of protein oligomerization(GO:0032460)
0.0 0.1 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.4 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0 0.4 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.7 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.0 0.2 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.0 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.5 GO:1901796 regulation of signal transduction by p53 class mediator(GO:1901796)
0.0 0.2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.8 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.1 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.5 GO:0032272 negative regulation of protein polymerization(GO:0032272)
0.0 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.1 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.2 GO:0048839 inner ear development(GO:0048839)
0.0 0.0 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.1 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.0 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.1 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.3 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.4 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.6 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.7 6.9 GO:0032010 phagolysosome(GO:0032010)
0.4 2.2 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.4 4.7 GO:0005610 laminin-5 complex(GO:0005610)
0.4 5.1 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.4 1.2 GO:0072563 endothelial microparticle(GO:0072563)
0.3 3.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.3 1.0 GO:0008623 CHRAC(GO:0008623)
0.3 1.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 2.0 GO:1990393 3M complex(GO:1990393)
0.2 2.8 GO:0061689 tricellular tight junction(GO:0061689)
0.2 4.3 GO:0070938 contractile ring(GO:0070938)
0.2 0.2 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.2 1.0 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.2 3.4 GO:0071438 invadopodium membrane(GO:0071438)
0.2 3.0 GO:0043219 lateral loop(GO:0043219)
0.2 3.3 GO:0031209 SCAR complex(GO:0031209)
0.2 0.7 GO:0070985 TFIIK complex(GO:0070985)
0.2 1.9 GO:0005833 hemoglobin complex(GO:0005833)
0.2 0.7 GO:0031592 centrosomal corona(GO:0031592)
0.2 1.2 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.6 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 0.6 GO:0055087 Ski complex(GO:0055087)
0.1 0.4 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.4 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.4 GO:0030689 Noc complex(GO:0030689)
0.1 2.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.6 GO:0042643 actomyosin, actin portion(GO:0042643)
0.1 8.6 GO:0002102 podosome(GO:0002102)
0.1 0.1 GO:0097443 sorting endosome(GO:0097443)
0.1 0.7 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 0.3 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 2.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.1 1.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.3 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.3 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 1.2 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.4 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 4.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.6 GO:0070435 Shc-EGFR complex(GO:0070435)
0.1 0.7 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 1.2 GO:0097433 dense body(GO:0097433)
0.1 8.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 2.3 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.1 0.2 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.1 5.9 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 10.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.7 GO:0000322 storage vacuole(GO:0000322)
0.1 5.8 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.2 GO:0036457 keratohyalin granule(GO:0036457)
0.1 0.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 3.9 GO:0001533 cornified envelope(GO:0001533)
0.1 0.9 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0071159 NF-kappaB complex(GO:0071159)
0.0 0.7 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0042022 interleukin-12 receptor complex(GO:0042022)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.0 1.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.9 GO:0030897 HOPS complex(GO:0030897)
0.0 0.8 GO:0090543 Flemming body(GO:0090543)
0.0 1.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.6 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 0.3 GO:0032009 early phagosome(GO:0032009)
0.0 0.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 1.2 GO:0010369 chromocenter(GO:0010369)
0.0 0.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 6.0 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.3 GO:0097452 GAIT complex(GO:0097452)
0.0 0.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.1 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.4 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.6 GO:0005915 zonula adherens(GO:0005915)
0.0 0.6 GO:1990909 Wnt signalosome(GO:1990909)
0.0 1.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0070110 ciliary neurotrophic factor receptor complex(GO:0070110)
0.0 0.5 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.0 0.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 2.0 GO:0031201 SNARE complex(GO:0031201)
0.0 0.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0036284 tubulobulbar complex(GO:0036284)
0.0 5.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 2.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 8.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.5 GO:0005861 troponin complex(GO:0005861)
0.0 4.8 GO:0043209 myelin sheath(GO:0043209)
0.0 0.1 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.5 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.5 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 2.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.4 GO:0070603 SWI/SNF superfamily-type complex(GO:0070603)
0.0 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 1.0 GO:0043195 terminal bouton(GO:0043195)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.1 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 1.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.1 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.2 9.4 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.9 2.8 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.9 2.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.9 10.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7 15.7 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.5 1.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.5 8.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.4 2.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.4 1.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.4 2.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 3.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.3 1.0 GO:0086040 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086040)
0.3 7.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 1.5 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.3 1.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.3 1.4 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.3 1.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.3 3.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.2 2.2 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.2 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 5.1 GO:0015643 toxic substance binding(GO:0015643)
0.2 1.2 GO:0070064 proline-rich region binding(GO:0070064)
0.2 0.8 GO:0004132 dCMP deaminase activity(GO:0004132)
0.2 2.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 9.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 2.3 GO:0097016 L27 domain binding(GO:0097016)
0.2 6.5 GO:0017166 vinculin binding(GO:0017166)
0.2 4.7 GO:0031005 filamin binding(GO:0031005)
0.2 1.2 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.2 0.5 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.2 0.6 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.2 0.9 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.2 1.2 GO:0005534 galactose binding(GO:0005534)
0.1 0.6 GO:1902379 receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.1 3.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.7 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 1.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 0.7 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 2.4 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 1.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 0.5 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.1 2.4 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.1 GO:0035500 MH2 domain binding(GO:0035500)
0.1 2.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 5.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.3 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 0.4 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 1.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.7 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.9 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 3.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 1.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.4 GO:0015616 DNA translocase activity(GO:0015616)
0.1 2.0 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 5.0 GO:0001671 ATPase activator activity(GO:0001671)
0.1 2.8 GO:0031402 sodium ion binding(GO:0031402)
0.1 0.3 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.1 0.5 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.4 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 3.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 1.2 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.7 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 8.9 GO:0001618 virus receptor activity(GO:0001618)
0.1 0.4 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.1 0.2 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.1 1.1 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 0.2 GO:0019961 interferon binding(GO:0019961)
0.1 0.6 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 1.0 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 5.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 1.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.5 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 1.6 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 0.4 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 1.7 GO:0050700 CARD domain binding(GO:0050700)
0.1 4.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.3 GO:0005334 norepinephrine:sodium symporter activity(GO:0005334)
0.1 2.2 GO:0001848 complement binding(GO:0001848)
0.1 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.3 GO:0098808 mRNA cap binding(GO:0098808)
0.1 1.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.7 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 0.9 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 0.6 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 3.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.0 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.2 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.1 1.0 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 1.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.3 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.1 0.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.4 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.7 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.5 GO:0016805 dipeptidase activity(GO:0016805)
0.1 1.7 GO:0005112 Notch binding(GO:0005112)
0.1 0.5 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 1.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.4 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 1.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 1.1 GO:0008494 translation activator activity(GO:0008494)
0.1 1.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.6 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.7 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0016517 interleukin-12 receptor activity(GO:0016517)
0.0 6.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 2.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 2.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.0 0.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.5 GO:0015386 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.0 0.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.5 GO:0015288 porin activity(GO:0015288)
0.0 1.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.4 GO:0030911 TPR domain binding(GO:0030911)
0.0 3.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.4 GO:0036122 BMP binding(GO:0036122)
0.0 0.2 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.8 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.5 GO:0031014 troponin T binding(GO:0031014)
0.0 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.6 GO:0000150 recombinase activity(GO:0000150)
0.0 2.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.1 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 2.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.7 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 1.7 GO:0070888 E-box binding(GO:0070888)
0.0 3.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 3.7 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 3.9 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.3 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 4.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.0 1.6 GO:0043621 protein self-association(GO:0043621)
0.0 4.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 5.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 3.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.7 GO:0001047 core promoter binding(GO:0001047)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0097643 amylin receptor activity(GO:0097643)
0.0 0.1 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.0 0.4 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.1 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.0 4.3 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 2.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.6 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.6 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.2 GO:0031543 peptidyl-proline dioxygenase activity(GO:0031543)
0.0 0.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0071837 HMG box domain binding(GO:0071837)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 5.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 16.3 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.2 7.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 5.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 4.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 2.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 7.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 6.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 4.0 PID MYC PATHWAY C-MYC pathway
0.1 3.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 3.4 ST GAQ PATHWAY G alpha q Pathway
0.1 8.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 9.2 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 0.9 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 4.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 4.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 3.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 3.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.9 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.6 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 2.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 5.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 1.0 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.0 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.4 PID FOXO PATHWAY FoxO family signaling
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.1 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.4 SIG CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 3.4 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 3.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 2.9 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 6.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 2.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 4.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 5.9 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 3.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.1 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.1 3.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.4 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 0.9 REACTOME OPIOID SIGNALLING Genes involved in Opioid Signalling
0.1 1.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.9 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.1 3.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 3.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 0.6 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 0.7 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.1 2.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 8.7 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 1.2 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 13.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 5.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 2.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.0 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.1 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.0 1.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.7 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.2 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 2.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.0 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.1 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.7 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.3 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.7 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.6 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.0 0.3 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 2.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation