ISMARA results: SPI1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPI1

Z-value: 1.91

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Transcription factors associated with SPI1

Gene Symbol	Gene ID	Gene Info
SPI1 Ensembl NCBI GeneCards UniProt	ENSG00000066336.7	Spi-1 proto-oncogene

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SPI1	hg19_v2_chr11_-_47400062_47400077	-0.52	1.8e-02	Click!

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

No targets for SPI1

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.4	GO:0007173	epidermal growth factor receptor signaling pathway(GO:0007173)
1.5	10.6	GO:0071461	cellular response to redox state(GO:0071461)
0.8	9.7	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.9	9.6	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
1.9	9.4	GO:0045658	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.5	6.0	GO:0060753	regulation of mast cell chemotaxis(GO:0060753)
0.3	6.0	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.1	5.7	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.6	5.6	GO:1902952	positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.5	5.1	GO:1904379	protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)

Showing 1 to 10 of 346 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.1	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
3.2	9.6	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.0	8.8	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1	8.6	GO:0002102	podosome(GO:0002102)
0.1	8.1	GO:0035577	azurophil granule membrane(GO:0035577)
0.7	6.9	GO:0032010	phagolysosome(GO:0032010)
0.0	6.0	GO:0005604	basement membrane(GO:0005604)
0.1	5.9	GO:0043198	dendritic shaft(GO:0043198)
0.1	5.8	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	5.5	GO:0031225	anchored component of membrane(GO:0031225)

Showing 1 to 10 of 144 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	15.7	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.9	10.6	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2	9.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
1.2	9.4	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	8.9	GO:0001618	virus receptor activity(GO:0001618)
0.5	8.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.3	7.0	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	6.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	6.5	GO:0017166	vinculin binding(GO:0017166)
0.1	5.8	GO:0070577	lysine-acetylated histone binding(GO:0070577)

Showing 1 to 10 of 218 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.3	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	9.2	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.2	8.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	8.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.2	7.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	7.4	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	6.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.2	5.8	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	5.4	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	5.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2

Showing 1 to 10 of 46 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	8.7	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1	6.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.1	5.9	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	5.1	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	4.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	3.9	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	3.5	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.2	3.4	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	3.3	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters

Showing 1 to 10 of 72 entries

Results for SPI1

Z-value: 1.91

Motif logo

Transcription factors associated with SPI1

Activity-expression correlation:

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

No targets for SPI1

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: