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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPIB

Z-value: 2.54

Motif logo

Transcription factors associated with SPIB

Gene Symbol Gene ID Gene Info
ENSG00000269404.2 Spi-B transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPIBhg19_v2_chr19_+_50922187_50922215-0.454.5e-02Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 21.7 GO:0071461 cellular response to redox state(GO:0071461)
1.3 6.6 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
1.3 5.1 GO:0071226 response to molecule of fungal origin(GO:0002238) cellular response to molecule of fungal origin(GO:0071226)
1.0 3.1 GO:0045404 positive regulation of interleukin-4 biosynthetic process(GO:0045404)
1.0 5.0 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.0 3.9 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.9 10.4 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.9 10.6 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.9 5.2 GO:0042335 cuticle development(GO:0042335)
0.8 3.3 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.8 5.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.7 6.3 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.7 4.2 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.7 3.5 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.6 7.0 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.5 3.7 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.5 4.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.5 1.4 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.4 3.1 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.4 1.2 GO:2000744 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.4 1.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.4 4.5 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.4 6.2 GO:0006600 creatine metabolic process(GO:0006600)
0.3 1.7 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.3 2.6 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.3 4.8 GO:0060613 fat pad development(GO:0060613)
0.3 2.2 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.3 4.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 1.5 GO:0032796 uropod organization(GO:0032796)
0.3 4.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.3 4.0 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.3 5.7 GO:0016540 protein autoprocessing(GO:0016540)
0.3 1.3 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.3 1.1 GO:0044407 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.3 0.8 GO:0042040 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.3 4.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 1.0 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.2 3.1 GO:0090487 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.2 2.8 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.2 2.3 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.2 1.2 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.2 1.4 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.2 0.7 GO:1903371 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.2 0.6 GO:0061485 memory T cell proliferation(GO:0061485)
0.2 0.6 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.2 1.2 GO:0001692 histamine metabolic process(GO:0001692)
0.2 3.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 0.7 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.2 2.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 0.6 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.2 1.2 GO:1903977 positive regulation of glial cell migration(GO:1903977)
0.2 0.5 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
0.2 1.0 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.2 1.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 3.1 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 3.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 1.2 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 1.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.5 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 0.6 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 0.6 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 1.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.9 GO:0061198 fungiform papilla formation(GO:0061198)
0.1 1.6 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.1 0.5 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.8 GO:1901526 negative regulation of mitochondrial fusion(GO:0010637) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.1 1.7 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 0.7 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.7 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 2.8 GO:0007172 signal complex assembly(GO:0007172)
0.1 1.7 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 1.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.5 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.1 1.3 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 0.5 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 1.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 1.0 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.2 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.1 0.1 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.1 0.6 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.5 GO:0039019 pronephric nephron development(GO:0039019)
0.1 0.3 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.1 0.8 GO:0006105 succinate metabolic process(GO:0006105)
0.1 0.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.7 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 3.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.1 GO:0090168 Golgi reassembly(GO:0090168)
0.1 1.6 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 1.1 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 2.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 0.7 GO:0035973 aggrephagy(GO:0035973)
0.1 0.4 GO:0030879 mammary gland development(GO:0030879)
0.1 0.4 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.1 GO:0061183 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183)
0.1 3.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.3 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.1 2.8 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.0 0.8 GO:0001955 blood vessel maturation(GO:0001955)
0.0 1.7 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.9 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.5 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.4 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.2 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 1.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 6.9 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.2 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.4 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.5 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0 0.2 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.2 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 6.0 GO:0070268 cornification(GO:0070268)
0.0 2.4 GO:0008038 neuron recognition(GO:0008038)
0.0 1.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 1.9 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 0.2 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.2 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.3 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.6 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 0.6 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.5 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 1.5 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.4 GO:0060022 hard palate development(GO:0060022)
0.0 0.3 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.0 1.6 GO:1901998 toxin transport(GO:1901998)
0.0 3.9 GO:0030183 B cell differentiation(GO:0030183)
0.0 1.7 GO:0031325 positive regulation of cellular metabolic process(GO:0031325)
0.0 0.6 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.8 GO:0009299 mRNA transcription(GO:0009299)
0.0 1.8 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.6 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.0 GO:0071287 cellular response to manganese ion(GO:0071287)
0.0 1.0 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.2 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0035878 nail development(GO:0035878)
0.0 1.8 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 1.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 1.4 GO:0007004 telomere maintenance via telomerase(GO:0007004)
0.0 1.1 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.6 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.5 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 1.3 GO:0032465 regulation of cytokinesis(GO:0032465)
0.0 0.0 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.8 GO:0021762 substantia nigra development(GO:0021762)
0.0 0.4 GO:0001525 angiogenesis(GO:0001525)
0.0 0.6 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 0.3 GO:0034332 adherens junction organization(GO:0034332)
0.0 1.1 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.1 GO:0031673 H zone(GO:0031673)
0.6 4.4 GO:0019815 B cell receptor complex(GO:0019815)
0.6 1.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.6 7.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.4 3.1 GO:1990130 Iml1 complex(GO:1990130)
0.4 3.7 GO:0005955 calcineurin complex(GO:0005955)
0.3 3.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 2.3 GO:0033503 HULC complex(GO:0033503)
0.2 0.8 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.2 0.8 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.2 1.0 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.2 1.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 0.7 GO:0097635 extrinsic component of autophagosome membrane(GO:0097635)
0.2 3.1 GO:0070938 contractile ring(GO:0070938)
0.2 0.5 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.1 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.4 GO:0033263 CORVET complex(GO:0033263)
0.1 1.0 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 4.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.6 GO:0072487 MSL complex(GO:0072487)
0.1 1.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.7 GO:0030478 actin cap(GO:0030478)
0.1 1.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 11.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.4 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 1.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.6 GO:0070847 core mediator complex(GO:0070847)
0.1 1.0 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.4 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 1.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 1.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.4 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 1.6 GO:0030904 retromer complex(GO:0030904)
0.1 0.2 GO:0071159 NF-kappaB complex(GO:0071159)
0.1 0.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.6 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.1 GO:0005861 troponin complex(GO:0005861)
0.0 1.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 4.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 5.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 3.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.6 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 4.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.6 GO:0016600 flotillin complex(GO:0016600)
0.0 1.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0032449 CBM complex(GO:0032449)
0.0 2.4 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.2 GO:0044295 axonal growth cone(GO:0044295)
0.0 5.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 5.6 GO:0005795 Golgi stack(GO:0005795)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 2.0 GO:0030315 T-tubule(GO:0030315)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.4 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 5.8 GO:0005770 late endosome(GO:0005770)
0.0 0.3 GO:0097610 cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 3.3 GO:0005681 spliceosomal complex(GO:0005681)
0.0 1.2 GO:0030175 filopodium(GO:0030175)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.5 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 4.7 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 3.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
1.8 21.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.8 6.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.7 1.4 GO:0097110 scaffold protein binding(GO:0097110)
0.6 6.2 GO:0004111 creatine kinase activity(GO:0004111)
0.6 5.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 3.1 GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.5 1.9 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.4 1.7 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.4 1.7 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.4 5.0 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.4 1.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 1.3 GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.3 7.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 4.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 2.0 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.3 0.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.3 3.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 1.7 GO:0039552 RIG-I binding(GO:0039552)
0.3 0.8 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.3 5.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.3 0.8 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.2 4.5 GO:0008494 translation activator activity(GO:0008494)
0.2 2.8 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.2 2.6 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 6.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 1.9 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 9.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 4.2 GO:0045499 chemorepellent activity(GO:0045499)
0.2 6.5 GO:0017166 vinculin binding(GO:0017166)
0.2 0.5 GO:0030626 U12 snRNA binding(GO:0030626)
0.2 1.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 0.5 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 1.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 3.5 GO:0097602 cullin family protein binding(GO:0097602)
0.1 1.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 3.1 GO:0016918 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.1 8.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 1.7 GO:0045159 myosin II binding(GO:0045159)
0.1 1.1 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.7 GO:0005499 vitamin D binding(GO:0005499)
0.1 1.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 1.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 4.1 GO:0005521 lamin binding(GO:0005521)
0.1 4.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.6 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 2.2 GO:0031432 titin binding(GO:0031432)
0.1 4.0 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 1.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.1 GO:0031014 troponin T binding(GO:0031014)
0.1 1.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 6.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 1.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.0 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 1.5 GO:0005537 mannose binding(GO:0005537)
0.1 0.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 2.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.1 0.7 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 3.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 2.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 3.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.7 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 1.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.3 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.4 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 1.9 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 2.2 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 1.1 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 4.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.8 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 1.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 8.6 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 1.0 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.8 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.2 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 2.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 4.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 1.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.8 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.5 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 1.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.2 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0001032 RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.0 0.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 9.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 4.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 21.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 8.7 PID IL3 PATHWAY IL3-mediated signaling events
0.1 6.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 2.9 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 6.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 5.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 6.5 PID IL1 PATHWAY IL1-mediated signaling events
0.1 3.7 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 5.0 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.9 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 1.7 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 2.8 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 3.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 5.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.8 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 2.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 6.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 PID IL6 7 PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 2.9 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.2 9.4 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 8.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 1.0 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 4.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 3.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 2.8 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 0.8 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 24.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 14.7 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 6.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 6.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 3.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 16.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.0 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.9 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.4 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.9 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 0.5 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.5 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 1.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation