ISMARA results: SPIB

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPIB

Z-value: 2.54

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Transcription factors associated with SPIB

Gene Symbol	Gene ID	Gene Info
SPIB Ensembl NCBI GeneCards UniProt	ENSG00000269404.2	Spi-B transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SPIB	hg19_v2_chr19_+_50922187_50922215	-0.45	4.5e-02	Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

No targets for SPIB

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	21.7	GO:0071461	cellular response to redox state(GO:0071461)
0.9	10.6	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.9	10.4	GO:0060753	regulation of mast cell chemotaxis(GO:0060753)
0.6	7.0	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)
0.0	6.9	GO:0006903	vesicle targeting(GO:0006903)
1.3	6.6	GO:0045659	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.7	6.3	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.4	6.2	GO:0006600	creatine metabolic process(GO:0006600)
0.0	6.0	GO:0070268	cornification(GO:0070268)
0.3	5.7	GO:0016540	protein autoprocessing(GO:0016540)

Showing 1 to 10 of 156 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.0	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.6	7.0	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	5.8	GO:0005770	late endosome(GO:0005770)
0.0	5.6	GO:0005795	Golgi stack(GO:0005795)
0.0	5.4	GO:0005882	intermediate filament(GO:0005882)
0.0	5.0	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	4.8	GO:0005876	spindle microtubule(GO:0005876)
0.0	4.7	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1	4.5	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.6	4.4	GO:0019815	B cell receptor complex(GO:0019815)

Showing 1 to 10 of 84 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	21.7	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2	9.7	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	8.7	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	8.6	GO:0019887	protein kinase regulator activity(GO:0019887)
0.3	7.0	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.8	6.6	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2	6.5	GO:0017166	vinculin binding(GO:0017166)
0.2	6.4	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
2.1	6.3	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
0.6	6.2	GO:0004111	creatine kinase activity(GO:0004111)

Showing 1 to 10 of 113 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	21.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.2	9.4	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	8.7	PID IL3 PATHWAY	IL3-mediated signaling events
0.3	7.0	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	6.8	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	6.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	6.5	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	6.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	5.9	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	5.0	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Showing 1 to 10 of 25 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	24.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	16.5	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	14.7	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2	9.4	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.2	8.7	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	6.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	6.0	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	4.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.3	4.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	3.5	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER

Showing 1 to 10 of 46 entries

Results for SPIB

Z-value: 2.54

Motif logo

Transcription factors associated with SPIB

Activity-expression correlation:

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

No targets for SPIB

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: