Project
avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for HOXA4
Z-value: 1.29
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Transcription factors associated with HOXA4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA4 | hg38_v1_chr7_-_27130182_27130226 | -0.55 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_104085847 Show fit | 1.81 |
ENST00000648076.2
|
collagen type XVII alpha 1 chain |
|
| chr5_+_53480619 Show fit | 1.56 |
ENST00000396947.7
ENST00000256759.8 |
follistatin |
|
| chr5_-_1882902 Show fit | 0.94 |
ENST00000231357.7
|
iroquois homeobox 4 |
|
| chr5_+_67004618 Show fit | 0.78 |
ENST00000261569.11
ENST00000436277.5 |
microtubule associated serine/threonine kinase family member 4 |
|
| chr14_-_53956811 Show fit | 0.60 |
ENST00000559087.5
ENST00000245451.9 |
bone morphogenetic protein 4 |
|
| chr4_+_83536097 Show fit | 0.56 |
ENST00000395226.6
ENST00000264409.5 |
glycerol-3-phosphate acyltransferase 3 |
|
| chr18_+_31376777 Show fit | 0.55 |
ENST00000308128.9
ENST00000359747.4 |
desmoglein 4 |
|
| chr15_+_90201301 Show fit | 0.53 |
ENST00000411539.6
|
semaphorin 4B |
|
| chr8_-_42501224 Show fit | 0.52 |
ENST00000520262.6
ENST00000517366.1 |
solute carrier family 20 member 2 |
|
| chr1_-_204359885 Show fit | 0.43 |
ENST00000414478.1
ENST00000272203.8 |
pleckstrin homology domain containing A6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 1.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 1.6 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) positive regulation of hair follicle development(GO:0051798) |
| 0.3 | 0.9 | GO:0048560 | establishment of anatomical structure orientation(GO:0048560) |
| 0.1 | 0.8 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.2 | 0.7 | GO:0016116 | tetraterpenoid metabolic process(GO:0016108) carotenoid metabolic process(GO:0016116) carotene catabolic process(GO:0016121) xanthophyll metabolic process(GO:0016122) terpene catabolic process(GO:0046247) |
| 0.2 | 0.6 | GO:0072099 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.0 | 0.6 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 0.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 0.5 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 1.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.8 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.4 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.3 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.2 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 0.0 | 0.2 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.0 | 0.2 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 0.9 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.2 | 0.8 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.1 | 0.7 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 0.6 | GO:0004366 | glycerol-3-phosphate O-acyltransferase activity(GO:0004366) |
| 0.0 | 0.6 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.5 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.0 | 0.5 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.4 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.1 | 0.4 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.8 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.4 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.4 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.2 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |