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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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ISMARA results avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

Original results

Sample Condition
01_GSM710379_01_HMLE-24hi_aEpithelial
02_GSM710383_05_HMLE-24hi_bEpithelial
03_GSM710380_02_HMLE-msp1_aMesenchymal
04_GSM710381_03_HMLE-msp2_aMesenchymal
05_GSM710382_04_HMLE-msp3_aMesenchymal
06_GSM710384_06_HMLE-msp1_bMesenchymal
07_GSM710385_07_HMLE-msp2_bMesenchymal
08_GSM710386_08_HMLE-msp3_bMesenchymal

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
ZEB1 18.32 small profile SeqLogo of ZEB1
ID4_TCF4_SNAI2 6.39 small profile SeqLogo of ID4_TCF4_SNAI2
TWIST1_SNAI1 4.83 small profile SeqLogo of TWIST1_SNAI1
MXI1_MYC_MYCN 4.13 small profile SeqLogo of MXI1_MYC_MYCN
NRF1 3.98 small profile SeqLogo of NRF1
KLF1 3.88 small profile SeqLogo of KLF1
FOSL1 3.82 small profile SeqLogo of FOSL1
TAF1 3.75 small profile SeqLogo of TAF1
EPAS1_BCL3 3.61 small profile SeqLogo of EPAS1_BCL3
NR1I2 3.39 small profile SeqLogo of NR1I2
NR2E3 3.30 small profile SeqLogo of NR2E3
MBD2 3.27 small profile SeqLogo of MBD2
IKZF1 3.25 small profile SeqLogo of IKZF1
GATA2 3.21 small profile SeqLogo of GATA2
AGCAGCA 3.19 small profile SeqLogo of AGCAGCA
ERG 3.06 small profile SeqLogo of ERG
CUX1 3.03 small profile SeqLogo of CUX1
BARHL1 2.99 small profile SeqLogo of BARHL1
TBP 2.92 small profile SeqLogo of TBP
MAFB 2.89 small profile SeqLogo of MAFB
E2F3 2.88 small profile SeqLogo of E2F3
HNF4G 2.88 small profile SeqLogo of HNF4G
ESRRA_ESR2 2.86 small profile SeqLogo of ESRRA_ESR2
SPIC 2.78 small profile SeqLogo of SPIC
MEIS2 2.76 small profile SeqLogo of MEIS2
HOXB6_PRRX2 2.70 small profile SeqLogo of HOXB6_PRRX2
MEIS1 2.70 small profile SeqLogo of MEIS1
ELK4_ETV5_ELK1_ELK3_ELF4 2.68 small profile SeqLogo of ELK4_ETV5_ELK1_ELK3_ELF4
CCCUGAG 2.68 small profile SeqLogo of CCCUGAG
ZBTB6 2.65 small profile SeqLogo of ZBTB6
MLX_USF2_USF1_PAX2 2.60 small profile SeqLogo of MLX_USF2_USF1_PAX2
ETV1_ERF_FEV_ELF1 2.58 small profile SeqLogo of ETV1_ERF_FEV_ELF1
NFATC4 2.58 small profile SeqLogo of NFATC4
YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ 2.57 small profile SeqLogo of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
AGCACCA 2.57 small profile SeqLogo of AGCACCA
EBF1 2.52 small profile SeqLogo of EBF1
MIXL1_GSX1_BSX_MEOX2_LHX4 2.48 small profile SeqLogo of MIXL1_GSX1_BSX_MEOX2_LHX4
GLI3 2.35 small profile SeqLogo of GLI3
WRNIP1 2.35 small profile SeqLogo of WRNIP1
FOXO3_FOXD2 2.33 small profile SeqLogo of FOXO3_FOXD2
HIC2 2.26 small profile SeqLogo of HIC2
NFE2L1 2.24 small profile SeqLogo of NFE2L1
MZF1 2.23 small profile SeqLogo of MZF1
E2F6 2.22 small profile SeqLogo of E2F6
ZNF711_TFAP2A_TFAP2D 2.18 small profile SeqLogo of ZNF711_TFAP2A_TFAP2D
TP63 2.18 small profile SeqLogo of TP63
PITX3 2.16 small profile SeqLogo of PITX3
LEF1 2.14 small profile SeqLogo of LEF1
TGIF1 2.12 small profile SeqLogo of TGIF1
ATF6 2.12 small profile SeqLogo of ATF6
CUX2 2.10 small profile SeqLogo of CUX2
CEBPA 2.08 small profile SeqLogo of CEBPA
ZNF652 2.08 small profile SeqLogo of ZNF652
SMAD4 2.08 small profile SeqLogo of SMAD4
TFAP2C 2.04 small profile SeqLogo of TFAP2C
GGAAUGU 2.01 small profile SeqLogo of GGAAUGU
IRF7 2.01 small profile SeqLogo of IRF7
OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 2.00 small profile SeqLogo of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4
SRF 1.98 small profile SeqLogo of SRF
SPIB 1.98 small profile SeqLogo of SPIB
TFEC_MITF_ARNTL_BHLHE41 1.97 small profile SeqLogo of TFEC_MITF_ARNTL_BHLHE41
RFX3_RFX2 1.96 small profile SeqLogo of RFX3_RFX2
OTX1 1.96 small profile SeqLogo of OTX1
NR0B1 1.96 small profile SeqLogo of NR0B1
FOXL1 1.95 small profile SeqLogo of FOXL1
FOSB 1.95 small profile SeqLogo of FOSB
HIVEP1 1.95 small profile SeqLogo of HIVEP1
OLIG3_NEUROD2_NEUROG2 1.94 small profile SeqLogo of OLIG3_NEUROD2_NEUROG2
GRHL1 1.91 small profile SeqLogo of GRHL1
FIGLA 1.91 small profile SeqLogo of FIGLA
ALX3 1.90 small profile SeqLogo of ALX3
SIX5_SMARCC2_HCFC1 1.90 small profile SeqLogo of SIX5_SMARCC2_HCFC1
UUGGUCC 1.89 small profile SeqLogo of UUGGUCC
RELA 1.88 small profile SeqLogo of RELA
XBP1 1.88 small profile SeqLogo of XBP1
ZBTB18 1.84 small profile SeqLogo of ZBTB18
TBX2 1.83 small profile SeqLogo of TBX2
AAUACUG 1.83 small profile SeqLogo of AAUACUG
IRF6_IRF4_IRF5 1.82 small profile SeqLogo of IRF6_IRF4_IRF5
SIN3A_CHD1 1.81 small profile SeqLogo of SIN3A_CHD1
ETV2 1.80 small profile SeqLogo of ETV2
RCOR1_MTA3 1.80 small profile SeqLogo of RCOR1_MTA3
BHLHE22_BHLHA15_BHLHE23 1.80 small profile SeqLogo of BHLHE22_BHLHA15_BHLHE23
MAZ_ZNF281_GTF2F1 1.78 small profile SeqLogo of MAZ_ZNF281_GTF2F1
RARG 1.78 small profile SeqLogo of RARG
HES1 1.76 small profile SeqLogo of HES1
ZBTB33_CHD2 1.76 small profile SeqLogo of ZBTB33_CHD2
GLI2 1.73 small profile SeqLogo of GLI2
FOXQ1 1.73 small profile SeqLogo of FOXQ1
TCF3_MYOG 1.72 small profile SeqLogo of TCF3_MYOG
KLF3 1.71 small profile SeqLogo of KLF3
ESRRB_ESRRG 1.70 small profile SeqLogo of ESRRB_ESRRG
DUXA 1.69 small profile SeqLogo of DUXA
CXXC1 1.68 small profile SeqLogo of CXXC1
CDC5L 1.66 small profile SeqLogo of CDC5L
CDX2 1.66 small profile SeqLogo of CDX2
ZNF143 1.64 small profile SeqLogo of ZNF143
BHLHE40 1.64 small profile SeqLogo of BHLHE40
HOXB3 1.62 small profile SeqLogo of HOXB3
MNT_HEY1_HEY2 1.60 small profile SeqLogo of MNT_HEY1_HEY2
CPEB1 1.60 small profile SeqLogo of CPEB1
GMEB1 1.59 small profile SeqLogo of GMEB1
MYBL1 1.58 small profile SeqLogo of MYBL1
AUUGCAC 1.55 small profile SeqLogo of AUUGCAC
SMAD1 1.55 small profile SeqLogo of SMAD1
SHOX 1.54 small profile SeqLogo of SHOX
HOXB8 1.54 small profile SeqLogo of HOXB8
HOXC12_HOXD12 1.52 small profile SeqLogo of HOXC12_HOXD12
TFAP2B 1.51 small profile SeqLogo of TFAP2B
UGGUCCC 1.49 small profile SeqLogo of UGGUCCC
RXRG 1.49 small profile SeqLogo of RXRG
FOSL2_SMARCC1 1.48 small profile SeqLogo of FOSL2_SMARCC1
HSF1 1.48 small profile SeqLogo of HSF1
AACACUG 1.46 small profile SeqLogo of AACACUG
EGR3_EGR2 1.46 small profile SeqLogo of EGR3_EGR2
NKX2-6 1.45 small profile SeqLogo of NKX2-6
MYBL2 1.44 small profile SeqLogo of MYBL2
ZBTB16 1.43 small profile SeqLogo of ZBTB16
FOXO4 1.43 small profile SeqLogo of FOXO4
WT1_MTF1_ZBTB7B 1.43 small profile SeqLogo of WT1_MTF1_ZBTB7B
HOXC8 1.43 small profile SeqLogo of HOXC8
DBP 1.43 small profile SeqLogo of DBP
POU2F2_POU3F1 1.41 small profile SeqLogo of POU2F2_POU3F1
RHOXF1 1.41 small profile SeqLogo of RHOXF1
TP53 1.40 small profile SeqLogo of TP53
DLX4_HOXD8 1.40 small profile SeqLogo of DLX4_HOXD8
SMAD2 1.38 small profile SeqLogo of SMAD2
SIX1_SIX3_SIX2 1.38 small profile SeqLogo of SIX1_SIX3_SIX2
RELB 1.36 small profile SeqLogo of RELB
HOXA13 1.35 small profile SeqLogo of HOXA13
MSX1 1.35 small profile SeqLogo of MSX1
AGUGCAA 1.34 small profile SeqLogo of AGUGCAA
CREB3L2 1.34 small profile SeqLogo of CREB3L2
HOXD1 1.33 small profile SeqLogo of HOXD1
TBX20 1.32 small profile SeqLogo of TBX20
DBX2_HLX 1.32 small profile SeqLogo of DBX2_HLX
HOXA4 1.29 small profile SeqLogo of HOXA4
FOXN1 1.28 small profile SeqLogo of FOXN1
ZIC3_ZIC4 1.28 small profile SeqLogo of ZIC3_ZIC4
ZNF423 1.28 small profile SeqLogo of ZNF423
PBX3 1.27 small profile SeqLogo of PBX3
EOMES 1.27 small profile SeqLogo of EOMES
HOMEZ 1.26 small profile SeqLogo of HOMEZ
YY1_YY2 1.26 small profile SeqLogo of YY1_YY2
ATF7 1.26 small profile SeqLogo of ATF7
EMX1 1.25 small profile SeqLogo of EMX1
REL 1.25 small profile SeqLogo of REL
IKZF2 1.24 small profile SeqLogo of IKZF2
HOXA1 1.24 small profile SeqLogo of HOXA1
TAL1 1.23 small profile SeqLogo of TAL1
PAX5 1.23 small profile SeqLogo of PAX5
PRRX1_ALX4_PHOX2A 1.22 small profile SeqLogo of PRRX1_ALX4_PHOX2A
AGCAGCG 1.22 small profile SeqLogo of AGCAGCG
FOXC1 1.21 small profile SeqLogo of FOXC1
AHR_ARNT2 1.21 small profile SeqLogo of AHR_ARNT2
STAT5A 1.21 small profile SeqLogo of STAT5A
FOXA1 1.21 small profile SeqLogo of FOXA1
IRF2_STAT2_IRF8_IRF1 1.20 small profile SeqLogo of IRF2_STAT2_IRF8_IRF1
SPI1 1.20 small profile SeqLogo of SPI1
AGUGCUU 1.19 small profile SeqLogo of AGUGCUU
ETV4_ETS2 1.18 small profile SeqLogo of ETV4_ETS2
MYF6 1.18 small profile SeqLogo of MYF6
HOXB4_LHX9 1.17 small profile SeqLogo of HOXB4_LHX9
FOXA2_FOXJ3 1.17 small profile SeqLogo of FOXA2_FOXJ3
TCF7L1 1.17 small profile SeqLogo of TCF7L1
RBPJ 1.17 small profile SeqLogo of RBPJ
PRDM1 1.17 small profile SeqLogo of PRDM1
HOXC9 1.16 small profile SeqLogo of HOXC9
GTF2I 1.14 small profile SeqLogo of GTF2I
NR2E1 1.12 small profile SeqLogo of NR2E1
SIX6 1.12 small profile SeqLogo of SIX6
INSM1 1.12 small profile SeqLogo of INSM1
E4F1 1.11 small profile SeqLogo of E4F1
HOXB7 1.11 small profile SeqLogo of HOXB7
POU5F1_POU2F3 1.11 small profile SeqLogo of POU5F1_POU2F3
TCF7L2 1.11 small profile SeqLogo of TCF7L2
VENTX 1.10 small profile SeqLogo of VENTX
NKX2-4 1.08 small profile SeqLogo of NKX2-4
TLX2 1.08 small profile SeqLogo of TLX2
ZNF524 1.08 small profile SeqLogo of ZNF524
UCCAGUU 1.07 small profile SeqLogo of UCCAGUU
GCUACAU 1.07 small profile SeqLogo of GCUACAU
ELF3_EHF 1.07 small profile SeqLogo of ELF3_EHF
MAFA 1.06 small profile SeqLogo of MAFA
IRX2 1.06 small profile SeqLogo of IRX2
ZNF691 1.06 small profile SeqLogo of ZNF691
PBX1 1.06 small profile SeqLogo of PBX1
HMX1 1.06 small profile SeqLogo of HMX1
HOXA5 1.06 small profile SeqLogo of HOXA5
ETV3 1.05 small profile SeqLogo of ETV3
MEF2D_MEF2A 1.05 small profile SeqLogo of MEF2D_MEF2A
BARHL2 1.03 small profile SeqLogo of BARHL2
SP1 1.01 small profile SeqLogo of SP1
CTCF_CTCFL 1.00 small profile SeqLogo of CTCF_CTCFL
ATF5 0.99 small profile SeqLogo of ATF5
MEF2B 0.98 small profile SeqLogo of MEF2B
KLF6 0.98 small profile SeqLogo of KLF6
SOX13_SOX12 0.98 small profile SeqLogo of SOX13_SOX12
POU4F1_POU4F3 0.98 small profile SeqLogo of POU4F1_POU4F3
FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 0.97 small profile SeqLogo of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
CEBPE_CEBPD 0.97 small profile SeqLogo of CEBPE_CEBPD
UBP1 0.96 small profile SeqLogo of UBP1
NR5A2 0.96 small profile SeqLogo of NR5A2
ZNF740_ZNF219 0.96 small profile SeqLogo of ZNF740_ZNF219
PRDM14 0.95 small profile SeqLogo of PRDM14
TBX3 0.95 small profile SeqLogo of TBX3
TEAD3_TEAD1 0.95 small profile SeqLogo of TEAD3_TEAD1
TFAP4_MSC 0.95 small profile SeqLogo of TFAP4_MSC
KLF16_SP2 0.94 small profile SeqLogo of KLF16_SP2
AACAGUC 0.94 small profile SeqLogo of AACAGUC
DLX1_HOXA3_BARX2 0.94 small profile SeqLogo of DLX1_HOXA3_BARX2
TBX21_TBR1 0.93 small profile SeqLogo of TBX21_TBR1
OLIG1 0.93 small profile SeqLogo of OLIG1
MLXIPL 0.92 small profile SeqLogo of MLXIPL
STAT1_STAT3_BCL6 0.91 small profile SeqLogo of STAT1_STAT3_BCL6
GLIS2 0.91 small profile SeqLogo of GLIS2
FOXK1_FOXP2_FOXB1_FOXP3 0.91 small profile SeqLogo of FOXK1_FOXP2_FOXB1_FOXP3
HIC1 0.90 small profile SeqLogo of HIC1
HESX1 0.90 small profile SeqLogo of HESX1
ETV7 0.90 small profile SeqLogo of ETV7
MESP1 0.90 small profile SeqLogo of MESP1
SCRT1_SCRT2 0.89 small profile SeqLogo of SCRT1_SCRT2
IRX5 0.88 small profile SeqLogo of IRX5
SREBF1_TFE3 0.88 small profile SeqLogo of SREBF1_TFE3
STAT5B 0.87 small profile SeqLogo of STAT5B
PTF1A 0.87 small profile SeqLogo of PTF1A
GCAGCAU 0.86 small profile SeqLogo of GCAGCAU
GCM2 0.86 small profile SeqLogo of GCM2
HMBOX1 0.86 small profile SeqLogo of HMBOX1
GAGGUAG 0.85 small profile SeqLogo of GAGGUAG
FOXJ2 0.85 small profile SeqLogo of FOXJ2
NHLH1 0.85 small profile SeqLogo of NHLH1
HSFY2 0.85 small profile SeqLogo of HSFY2
UGGCACU 0.84 small profile SeqLogo of UGGCACU
VSX1 0.84 small profile SeqLogo of VSX1
T 0.83
small profile SeqLogo of T
PPARG 0.83 small profile SeqLogo of PPARG
NFATC1 0.82 small profile SeqLogo of NFATC1
MAFK 0.82 small profile SeqLogo of MAFK
KLF12 0.82 small profile SeqLogo of KLF12
EZH2 0.82 small profile SeqLogo of EZH2
PATZ1_KLF4 0.82 small profile SeqLogo of PATZ1_KLF4
GCM1 0.81 small profile SeqLogo of GCM1
UAAGGCA 0.80 small profile SeqLogo of UAAGGCA
MAFF_MAFG 0.80 small profile SeqLogo of MAFF_MAFG
TFDP1 0.79 small profile SeqLogo of TFDP1
TBX5 0.79 small profile SeqLogo of TBX5
ZNF263 0.79 small profile SeqLogo of ZNF263
IRF9 0.78 small profile SeqLogo of IRF9
NR1H2 0.78 small profile SeqLogo of NR1H2
DMBX1 0.77 small profile SeqLogo of DMBX1
ZBTB12 0.76 small profile SeqLogo of ZBTB12
HOXD9 0.76 small profile SeqLogo of HOXD9
PKNOX2 0.76 small profile SeqLogo of PKNOX2
NR2C1 0.75 small profile SeqLogo of NR2C1
ZBTB3 0.74