Motif ID: Aire

Z-value: 1.033


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 84 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 26.787 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr9_-_124493793 2.463 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr10_-_130280218 2.050 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr5_-_84417359 0.957 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr4_+_63558748 0.762 ENSMUST00000077709.4
 6330416G13Rik
RIKEN cDNA 6330416G13 gene
chr2_+_55435918 0.708 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr9_+_109054839 0.681 ENSMUST00000154184.1
 Shisa5
shisa homolog 5 (Xenopus laevis)
chr14_+_21481428 0.677 ENSMUST00000182996.1
 Kat6b
K(lysine) acetyltransferase 6B
chr17_-_53463315 0.656 ENSMUST00000024725.4
 Efhb
EF hand domain family, member B
chr9_+_13662460 0.646 ENSMUST00000177755.1
 Maml2
mastermind like 2 (Drosophila)
chr19_+_46707443 0.585 ENSMUST00000003655.7
 As3mt
arsenic (+3 oxidation state) methyltransferase
chr10_+_37139558 0.581 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr12_-_78983476 0.552 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr16_-_91618986 0.545 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr8_-_4217133 0.530 ENSMUST00000175906.1
 BC068157
cDNA sequence BC068157
chr6_-_91515878 0.525 ENSMUST00000032182.3
 Xpc
xeroderma pigmentosum, complementation group C
chr1_+_65186727 0.514 ENSMUST00000097707.4
ENSMUST00000081154.7
 Pikfyve

phosphoinositide kinase, FYVE finger containing

chr4_-_19570073 0.509 ENSMUST00000029885.4
 Cpne3
copine III
chr5_-_50058908 0.504 ENSMUST00000030971.5
 Gpr125
G protein-coupled receptor 125
chr1_+_44119952 0.500 ENSMUST00000114709.2
 Bivm
basic, immunoglobulin-like variable motif containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 1.0 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.7 GO:0010107 potassium ion import(GO:0010107)
0.0 0.7 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 0.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.6 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 0.5 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.5 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.5 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.5 GO:0032288 myelin assembly(GO:0032288)
0.0 0.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.3 GO:0015813 L-glutamate transport(GO:0015813)
0.1 0.2 GO:0034241 positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289)
0.1 0.2 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.2 GO:0008300 isoprenoid catabolic process(GO:0008300)

Gene overrepresentation in cellular_component category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.5 GO:0071942 XPC complex(GO:0071942)
0.1 0.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0003684 damaged DNA binding(GO:0003684)
0.1 1.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 0.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.1 0.2 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.1 0.2 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.2 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)