ISMARA results

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
Hdx 9.112 Hdx
Nfatc1 7.472 Nfatc1
Irf2_Irf1_Irf8_Irf9_Irf7 4.642 Irf2
Irf1
Irf8
Irf9
Irf7
Chd1_Pml 4.501 Chd1
Pml
Hoxb7 4.283 Hoxb7
Zfp110 4.097 Zfp110
Yy1_Yy2 3.685 Yy1
Yy2
Sp100 3.379 Sp100
Tbp 2.922 Tbp
Wrnip1_Mta3_Rcor1 2.877 Wrnip1
Mta3
Rcor1
Nrf1 2.841 Nrf1
Ppara 2.693 Ppara
Sox2 2.620 Sox2
Tfdp1_Wt1_Egr2 2.609 Tfdp1
Wt1
Egr2
Taf1 2.408 Taf1
Stat2 2.394 Stat2
Nfatc3 2.381 Nfatc3
Esr2 2.286 Esr2
Ybx1_Nfya_Nfyb_Nfyc_Cebpz 2.203 Ybx1
Nfya
Nfyb
Nfyc
Cebpz
Elf1_Elf2_Etv2_Elf4 2.116 Elf1
Elf2
Etv2
Elf4
E2f1 2.095 E2f1
Onecut1_Cux2 2.035 Onecut1
Cux2
Cux2
Nfic_Nfib 2.029 Nfic
Nfib
Dmc1 1.985 Dmc1
Zbtb33_Chd2 1.980 Zbtb33
Chd2
Hmga2 1.966 Hmga2
Gtf2i_Gtf2f1 1.953 Gtf2i
Gtf2f1
Etv1_Etv5_Gabpa 1.933 Etv1
Etv5
Gabpa
Spic 1.930 Spic
Nfatc2 1.921 Nfatc2
Scrt2 1.920 Scrt2
Vdr 1.913 Vdr
Msx2_Hoxd4 1.882 Msx2
Dlx5_Dlx4 1.876 Dlx5
Dlx4
Runx2_Bcl11a 1.872 Runx2
Bcl11a
Pitx2_Otx2 1.830 Pitx2
Otx2
Nkx6-2 1.829 Nkx6-2
Tbr1 1.810 Tbr1
Smad1 1.802 Smad1
Hnf4g 1.793 Hnf4g
Max_Mycn 1.759 Max
Mycn
Sox3_Sox10 1.757 Sox3
Sox10
Sox5_Sry 1.749 Sox5
Sry
Hcfc1_Six5_Smarcc2_Zfp143 1.742 Hcfc1
Six5
Smarcc2
Zfp143
Elf3 1.738 Elf3
Nr1i3 1.719 Nr1i3
Myf6 1.712 Myf6
Meis2 1.696 Meis2
Gata3 1.684 Gata3
Hic1 1.664 Hic1
Gfi1_Gfi1b 1.656 Gfi1
Gfi1b
Nanog 1.615 Nanog
Zbtb14 1.611 Zbtb14
Gli1 1.608 Gli1
Pou5f1 1.591 Pou5f1
Zfx_Zfp711 1.571 Zfx
Zfp711
Snai1_Zeb1_Snai2 1.566 Snai1
Zeb1
Snai2
Ezh2_Atf2_Ikzf1 1.559 Ezh2
Atf2
Ikzf1
Pou1f1 1.553 Pou1f1
Foxi1_Foxo1 1.548 Foxi1
Foxo1
Tead3_Tead4 1.545 Tead3
Tead4
Maz_Zfp281 1.536 Maz
Zfp281
Hand1 1.535 Hand1
Sox6_Sox9 1.534 Sox6
Sox9
Hoxd12 1.524 Hoxd12
Tgif1_Meis3 1.522 Tgif1
Meis3
Nkx2-2 1.500 Nkx2-2
Zbtb4 1.500 Zbtb4
Prop1 1.500 Prop1
Six3_Six1_Six2 1.492 Six3
Six1
Six2
Klf6_Patz1 1.489 Klf6
Patz1
Foxd1 1.486 Foxd1
E2f2_E2f5 1.484 E2f2
E2f5
Hsf2 1.476 Hsf2
Ebf1 1.470 Ebf1
Ebf1
Spib 1.469 Spib
Gata5 1.450 Gata5
Myb 1.450 Myb
Cebpb 1.446 Cebpb
Zfp148 1.442 Zfp148
Lef1 1.438 Lef1
Scrt1 1.435 Scrt1
Tfap2c 1.425 Tfap2c
Zbtb7a 1.415 Zbtb7a
Lhx4 1.410 Lhx4
Pou2f1 1.409 Pou2f1
Pou6f2_Pou4f2 1.407 Pou6f2
Pou4f2
Srf 1.399 Srf
Pou2f2_Pou3f1 1.399 Pou2f2
Pou3f1
Cenpb 1.398 Cenpb
Hoxb3 1.397 Hoxb3
Pax5 1.395 Pax5
Prdm1 1.393 Prdm1
Gata2_Gata1 1.392 Gata2
Gata1
Foxb1 1.376 Foxb1
Nfia 1.376 Nfia
Glis3 1.375 Glis3
Glis3
Hmga1 1.374 Hmga1
Nfe2l1_Mafg 1.367 Nfe2l1
Mafg
Mafg
Tcf4_Mesp1 1.357 Tcf4
Mesp1
Rest 1.348 Rest
Zbtb16 1.348 Zbtb16
Tbx1_Eomes 1.345 Tbx1
Eomes
Osr2_Osr1 1.340 Osr2
Osr1
Junb_Jund 1.331 Junb
Jund
Rad21_Smc3 1.327 Rad21
Smc3
Hoxb2_Dlx2 1.325 Hoxb2
Dlx2
Gli3_Zic1 1.320 Gli3
Zic1
Tlx2 1.319 Tlx2
Cux1 1.314 Cux1
Epas1_Bcl3 1.306 Epas1
Bcl3
Egr3 1.301 Egr3
Hoxa6 1.286 Hoxa6
Ctcfl_Ctcf 1.283 Ctcfl
Ctcf
Mbd2 1.278 Mbd2
Dbp 1.275 Dbp
Zfp524 1.273 Zfp524
Pou2f3 1.269 Pou2f3
Klf4_Sp3 1.266 Klf4
Sp3
Tbx19 1.266 Tbx19
Hoxa4 1.263 Hoxa4
Id4 1.253 Id4
Lhx2_Hoxc5 1.252 Lhx2
Hoxc5
E2f8 1.251 E2f8
Rarg 1.248 Rarg
Etv3_Erf_Fev_Elk4_Elk1_Elk3 1.247 Etv3
Erf
Fev
Elk4
Elk1
Elk3
Tcf7l1 1.247 Tcf7l1
Rfx2_Rfx7 1.246 Rfx2
Rfx7
Foxa3 1.242 Foxa3
E2f7 1.242 E2f7
Egr1 1.239 Egr1
Tfcp2 1.238 Tfcp2
Zbtb6 1.234 Zbtb6
Cebpe 1.217 Cebpe
Ar 1.195 Ar
Pou4f1_Pou6f1 1.193 Pou4f1
Pou6f1
Mafa 1.190 Mafa
Mzf1 1.187 Mzf1
Tbx2 1.185 Tbx2
Klf16_Sp8 1.184 Klf16
Sp8
Hsf4 1.180 Hsf4
Zfp263 1.175 Zfp263
Zbtb7b 1.163 Zbtb7b
Foxc1 1.161 Foxc1
Foxf2 1.159 Foxf2
Isl2 1.158 Isl2
Irf3 1.156 Irf3
Ebf3 1.155 Ebf3
Ubp1 1.148 Ubp1
Meox2 1.142 Meox2
Foxo4 1.140 Foxo4
Mybl2 1.139 Mybl2
Sox15 1.139 Sox15
Foxp1_Foxj2 1.137 Foxp1
Foxj2
Rfx3_Rfx1_Rfx4 1.137 Rfx3
Rfx1
Rfx4
Ikzf2 1.136 Ikzf2
Mef2d_Mef2a 1.134 Mef2d
Mef2a
Hey1_Myc_Mxi1 1.133 Hey1
Myc
Mxi1
Atf5 1.128 Atf5
Mybl1 1.122 Mybl1
Tfap4 1.119 Tfap4
Creb1 1.116 Creb1
Foxq1 1.112 Foxq1
Tcf3 1.111 Tcf3
Glis2 1.109 Glis2
Stat5a 1.108 Stat5a
Mtf1 1.107 Mtf1
Nr2c2 1.106 Nr2c2
Gcm2 1.101 Gcm2
E2f4 1.094 E2f4
Foxj3_Tbl1xr1 1.094 Foxj3
Tbl1xr1
Ahr 1.094 Ahr
Zfp384 1.086 Zfp384
Tfap2a 1.084 Tfap2a
Sox14 1.083 Sox14
Foxl1 1.081 Foxl1
Foxl1
Nfe2_Bach1_Mafk 1.076 Nfe2
Bach1
Mafk
Atf4 1.070 Atf4
Nfkb2 1.060 Nfkb2
Mecp2 1.059 Mecp2
Hivep1 1.058 Hivep1
Klf1 1.055 Klf1
Erg 1.050 Erg
Tgif2_Tgif2lx1_Tgif2lx2 1.048 Tgif2
Tgif2lx1
Tgif2lx2
Maff 1.048 Maff
Hey2 1.038 Hey2
Zbtb18 1.033 Zbtb18
Aire 1.033 Aire
Nhlh1 1.030 Nhlh1
Elf5 1.029 Elf5
Mecom 1.028 Mecom
Hif1a 1.022 Hif1a
Etv6 1.020 Etv6
Esrrb_Esrra 1.018 Esrrb
Esrra
Foxf1 1.017 Foxf1
Sin3a 1.014 Sin3a
Evx2 1.011 Evx2
Hoxc13_Hoxd13 1.009
Onecut2_Onecut3 1.007 Onecut2
Onecut3
Neurod1 1.006 Neurod1
Obox6_Obox5 1.002 Obox6
Obox5
Hoxb1 1.001 Hoxb1
Dlx1 1.000 Dlx1
Tfcp2l1 0.992 Tfcp2l1
Zfhx3 0.983 Zfhx3
Hoxb13 0.971 Hoxb13
Thra 0.970 Thra
Irx5 0.963 Irx5
Pax8 0.960 Pax8
Cdc5l 0.958 Cdc5l
Tfap2d 0.957 Tfap2d
Pax6 0.952 Pax6
Hoxa11_Hoxc12 0.951 Hoxa11
Hoxc12
Lhx5_Lmx1b_Lhx1 0.951 Lhx5
Lmx1b
Lhx1
Mef2c 0.950 Mef2c
Nkx2-5 0.950 Nkx2-5
E2f3 0.948 E2f3
Nr2e3 0.944 Nr2e3
Hsfy2 0.942 Hsfy2
Hes5_Hes7 0.937 Hes5
Hes7
Foxm1 0.937 Foxm1
Zfp219_Zfp740 0.935 Zfp219
Zfp740
Tal1 0.932 Tal1
Jun 0.931 Jun
Thrb 0.930 Thrb
Rela_Rel_Nfkb1 0.929 Rela
Rel
Nfkb1
Esr1 0.929 Esr1
Nr4a2 0.925 Nr4a2
Clock 0.919 Clock
Runx1 0.913 Runx1
Alx4 0.912 Alx4
Hnf1a 0.907 Hnf1a
Meis1 0.905 Meis1
Atf7_E4f1 0.898 Atf7
Atf7
E4f1
Rhox4e_Rhox6_Vax2 0.896 Rhox4e
Rhox6
Vax2
Bptf 0.895 Bptf
Obox1 0.893 Obox1
Rreb1 0.893 Rreb1
Fos 0.891 Fos
Gsx2_Hoxd3_Vax1 0.890 Gsx2
Hoxd3
Vax1
Ddit3 0.890 Ddit3
Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 0.890 Tfeb
Usf1
Srebf1
Usf2
Bhlhe41
Srebf2
Tfap2e 0.887 Tfap2e
Tlx1 0.885 Tlx1
Smad4 0.884 Smad4
Klf12_Klf14_Sp4 0.880 Klf12
Klf14
Sp4
Prrx1_Isx_Prrxl1 0.880 Prrx1
Isx
Prrxl1
Tcf7_Tcf7l2 0.880 Tcf7
Tcf7l2
Smad2 0.878 Smad2
Hoxd11_Cdx1_Hoxc11 0.876 Hoxd11
Cdx1
Hoxc11
Pitx3 0.873 Pitx3
Hoxa13 0.872 Hoxa13
Bhlhe40 0.868 Bhlhe40
Stat4_Stat3_Stat5b 0.867 Stat4
Stat3
Stat5b
Neurod2_Bhlha15_Bhlhe22_Olig1 0.862 Neurod2
Bhlha15
Bhlhe22
Olig1
Meox1 0.858 Meox1
Trp63 0.857 Trp63
Six6 0.856 Six6
Nkx3-1 0.855 Nkx3-1
Sp2 0.851 Sp2
Homez 0.850 Homez
Hoxa1 0.849 Hoxa1
Pbx2 0.849 Pbx2
Tbx5 0.849 Tbx5
Nfix 0.845 Nfix
Nkx3-2 0.844 Nkx3-2
Nkx6-1_Evx1_Hesx1 0.842 Nkx6-1
Evx1
Hesx1
Irf5_Irf6 0.839 Irf5
Irf6
Hmx1 0.838 Hmx1
Hinfp 0.836 Hinfp
Hoxb5 0.833 Hoxb5
Mef2b 0.831 Mef2b
Fosb 0.825 Fosb
Trp53 0.824 Trp53
Hnf1b 0.823 Hnf1b
Bcl6 0.822 Bcl6
Zic3 0.819 Zic3
Zkscan1 0.818 Zkscan1
Hoxd1 0.818 Hoxd1
Zbtb7c 0.818 Zbtb7c
Fubp1 0.816 Fubp1
Atf6 0.815 Atf6
Lhx8 0.815 Lhx8
Sp1 0.813 Sp1
Twist1 0.813 Twist1
Olig2_Olig3 0.812 Olig2
Olig3
Nr5a2 0.810 Nr5a2
Cdx2 0.810 Cdx2
En2 0.810 En2
Cpeb1 0.807 Cpeb1
Nkx2-4 0.804 Nkx2-4
Nr2f1_Nr4a1 0.803 Nr2f1
Nr4a1
Nkx6-3_Dbx2_Barx2 0.801 Nkx6-3
Dbx2
Barx2
Pparg_Rxrg 0.799 Pparg
Rxrg
Sox18_Sox12 0.796 Sox18
Sox12
Hoxc10 0.791 Hoxc10
Nfat5 0.790 Nfat5
Lhx3 0.789 Lhx3
Sox7 0.783 Sox7
Smarcc1_Fosl1 0.781 Smarcc1
Fosl1
Foxp2_Foxp3 0.780 Foxp2
Foxp3
Nfe2l2 0.780 Nfe2l2
Hsf1 0.778 Hsf1
Hes1 0.775 Hes1
Pax2 0.772 Pax2
Fosl2_Bach2 0.771 Fosl2
Bach2
Nr1h4 0.769 Nr1h4
Hoxb8_Pdx1 0.768 Hoxb8
Pdx1
Ets1 0.766 Ets1
Runx3 0.765 Runx3
Mnt 0.765 Mnt
Pou3f2 0.763 Pou3f2
E2f6 0.760 E2f6
Rbpj 0.758 Rbpj
Arid3a 0.757 Arid3a
Hoxa5 0.755 Hoxa5
Zfp105 0.754 Zfp105
Gmeb2 0.753 Gmeb2
En1 0.751 En1
Foxa2_Foxa1 0.749 Foxa2
Foxa1
Spdef 0.749 Spdef
Atf3 0.749 Atf3
Sox21 0.748 Sox21
Spi1 0.742 Spi1
Pax7 0.737 Pax7
Vsx1_Uncx_Prrx2_Shox2_Noto 0.735 Vsx1
Uncx
Prrx2
Shox2
Noto
Pbx1_Pbx3 0.734 Pbx1
Pbx3
Klf8 0.733 Klf8
Batf 0.732 Batf
Mnx1_Lhx6_Lmx1a 0.730 Mnx1
Lhx6
Lmx1a
Obox3 0.729 Obox3
Stat6 0.728 Stat6
Klf7 0.724 Klf7
Nkx2-3 0.719 Nkx2-3
Pitx1 0.718 Pitx1
Gcm1 0.718 Gcm1
Ptf1a 0.718 Ptf1a
Trp73 0.713 Trp73
Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec 0.711 Arntl
Tfe3
Mlx
Mitf
Mlxipl
Tfec
Irx6_Irx2_Irx3 0.710 Irx6
Irx2
Irx3
Maf_Nrl 0.709 Maf
Nrl
Hic2 0.709 Hic2
Gsc2_Dmbx1 0.706 Gsc2
Dmbx1
Bsx 0.706 Bsx
Ascl2 0.706 Ascl2
Zic2 0.702 Zic2
Sox4 0.697 Sox4
Zic4 0.696 Zic4
Hoxa10 0.694 Hoxa10
Msx1_Lhx9_Barx1_Rax_Dlx6 0.690 Msx1
Lhx9
Barx1
Rax
Dlx6
Irf4 0.690 Irf4
Egr4 0.688 Egr4
Tcf21_Msc 0.687 Tcf21
Msc
Zscan4c 0.679 Zscan4c
Tfap2b 0.677 Tfap2b
Hoxd9 0.677 Hoxd9
Nr4a3 0.675 Nr4a3
Crem_Jdp2 0.674 Crem
Jdp2
Plag1 0.673 Plag1
Hbp1 0.670 Hbp1
Bcl6b 0.667 Bcl6b
Pax4 0.667 Pax4
T 0.666 T
Fli1 0.665 Fli1
Foxd3 0.664 Foxd3
Zbtb3 0.664 Zbtb3
Ep300 0.664 Ep300
Zfp652 0.659 Zfp652
Nr1i2 0.657 Nr1i2
Pknox2_Pknox1 0.656 Pknox2
Pknox1
Pou4f3 0.651 Pou4f3
Mafb 0.649 Mafb
Relb 0.649 Relb
Prdm14 0.649 Prdm14
Isl1 0.648 Isl1
Nkx2-9 0.647 Nkx2-9
Foxo6 0.646 Foxo6
Hmbox1 0.644 Hmbox1
Rxrb 0.641 Rxrb
Pgr_Nr3c1 0.637 Pgr
Nr3c1
Myog_Tcf12 0.634 Myog
Tcf12
Gbx2 0.633 Gbx2
Rhox11 0.632 Rhox11
Foxn1 0.632 Foxn1
Nfil3_Tef 0.625 Nfil3
Tef
Atf1_Creb5 0.625 Atf1
Creb5
Nfatc4 0.625 Nfatc4
Nr6a1 0.621 Nr6a1
Hoxc4_Arx_Otp_Esx1_Phox2b 0.620 Hoxc4
Arx
Otp
Esx1
Phox2b
Hlf 0.618 Hlf
Nr1h2 0.617 Nr1h2
Zbtb49 0.616 Zbtb49
Cebpa_Cebpg 0.614 Cebpa
Cebpg
Zfp282 0.613 Zfp282
Foxo3 0.613 Foxo3
Klf13 0.613 Klf13
Vsx2_Dlx3 0.611 Vsx2
Dlx3
Sox11 0.610 Sox11
Rora 0.609 Rora
Hoxa2 0.607 Hoxa2
Hoxa9_Hoxb9 0.605 Hoxa9
Hoxb9
Gsx1_Alx1_Mixl1_Lbx2 0.602 Gsx1
Alx1
Mixl1
Lbx2
Nr2f2 0.597 Nr2f2
Nr2f6 0.594 Nr2f6
Sox17 0.592 Sox17
Zkscan3 0.592 Zkscan3
Esrrg 0.586 Esrrg
Atoh1_Bhlhe23 0.583 Atoh1
Bhlhe23
Brca1 0.580 Brca1
Tbx15 0.579 Tbx15
Hoxc9 0.579 Hoxc9
Hmx3 0.572 Hmx3
Sox30 0.570 Sox30
Gbx1_Nobox_Alx3 0.569 Gbx1
Nobox
Alx3
Zfp784 0.568 Zfp784
Gata4 0.566 Gata4
Xbp1_Creb3l1 0.565 Xbp1
Creb3l1
Insm1 0.560 Insm1
Foxk1_Foxj1 0.556 Foxk1
Foxj1
Nr3c2 0.555 Nr3c2
Ets2 0.552 Ets2
Nr0b1 0.552 Nr0b1
Mga 0.546 Mga
Klf15 0.541 Klf15
Nr2e1 0.540 Nr2e1
Gli2 0.536 Gli2
Plagl1 0.532 Plagl1
Tbx21 0.531 Tbx21
Myod1 0.525 Myod1
Figla 0.524 Figla
Zfp423 0.522 Zfp423
Creb3 0.521 Creb3
Neurog2 0.518 Neurog2
Foxd2 0.518 Foxd2
Cebpd 0.511 Cebpd
Grhl1 0.511 Grhl1
Creb3l2 0.511 Creb3l2
Etv4 0.510 Etv4
Rorc_Nr1d1 0.510 Rorc
Nr1d1
Foxc2 0.509 Foxc2
Arnt 0.508 Arnt
Pax1_Pax9 0.507 Pax1
Pax9
Hoxa3 0.503 Hoxa3
Zfp691 0.500 Zfp691
Tbx4 0.499 Tbx4
Rara 0.498 Rara
Sox1 0.495 Sox1
Prdm4 0.491 Prdm4
Hoxb4 0.490 Hoxb4
Rxra 0.489 Rxra
Zfp128 0.487 Zfp128
Pax3 0.487 Pax3
Gmeb1 0.485 Gmeb1
Tbx3 0.482 Tbx3
Six4 0.482 Six4
Crx_Gsc 0.480 Crx
Gsc
Pou3f4 0.480 Pou3f4
Rarb 0.478 Rarb
Smad3 0.478 Smad3
Rfx5 0.477 Rfx5
Ppard 0.475 Ppard
Msx3 0.474 Msx3
Stat1 0.473 Stat1
Hoxb6 0.467 Hoxb6
Hnf4a 0.458 Hnf4a
Emx1_Emx2 0.456 Emx1
Emx2
Nkx1-1_Nkx1-2 0.443 Nkx1-1
Nkx1-2
Hoxd8 0.441 Hoxd8
Sox8 0.440 Sox8
Hoxd10 0.439 Hoxd10
Prox1 0.439 Prox1
Hmx2 0.438 Hmx2
Arid5b 0.437 Arid5b
Nr2c1 0.436 Nr2c1
Hoxc6 0.433 Hoxc6
Batf3 0.420 Batf3
Tead1 0.417 Tead1
Foxg1 0.414 Foxg1
Cxxc1 0.410 Cxxc1
Barhl1 0.402 Barhl1
Gata6 0.398 Gata6
Nkx2-1 0.395 Nkx2-1
Arnt2 0.390 Arnt2
Bbx 0.384 Bbx
Phox2a 0.380 Phox2a
Hoxa7_Hoxc8 0.378 Hoxa7
Hoxc8
Klf3 0.378 Klf3
Ehf 0.364 Ehf
Barhl2 0.363 Barhl2
Zbtb12 0.351 Zbtb12
Cbfb 0.346 Cbfb
Otx1 0.345 Otx1
Sox13 0.322 Sox13
Gzf1 0.319 Gzf1
Tbx20 0.318 Tbx20
Arid5a 0.311 Arid5a
Nkx2-6 0.305 Nkx2-6
Zfp410 0.303 Zfp410
Irx4 0.287 Irx4
Hlx 0.208 Hlx
Ovol1 0.189 Ovol1
Pou3f3 0.174 Pou3f3
Glis1 0.095 Glis1

All samples sorted alphabetically


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Sample name Condition Replicate/Batch
E155_NBN_WT_1
E155_NBN_WT_2
E155_NBN_WT_3
E155_NBN_WT_4
E165_NBN_WT_1
E165_NBN_WT_2
E165_NBN_WT_3
E175_NBN_WT_1
E175_NBN_WT_2
E185_NBN_WT_1
E185_NBN_WT_2
E185_NBN_WT_3
PN_NBN_WT_1
PN_NBN_WT_2