Motif ID: Hand1

Z-value: 1.535


Transcription factors associated with Hand1:

Gene SymbolEntrez IDGene Name
Hand1 ENSMUSG00000037335.7 Hand1



Activity profile for motif Hand1.

activity profile for motif Hand1


Sorted Z-values histogram for motif Hand1

Sorted Z-values for motif Hand1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hand1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_37049203 5.187 ENSMUST00000037491.8
 F13a1
coagulation factor XIII, A1 subunit
chr13_-_92131494 5.015 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr11_+_82035569 3.643 ENSMUST00000000193.5
 Ccl2
chemokine (C-C motif) ligand 2
chr4_+_130913264 3.609 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr13_+_105443693 3.427 ENSMUST00000022235.4
 Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
chr15_+_81936911 3.261 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chrX_+_10485121 3.109 ENSMUST00000076354.6
ENSMUST00000115526.1
 Tspan7

tetraspanin 7

chr4_+_130913120 2.982 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr7_+_18884679 2.851 ENSMUST00000032573.6
 Pglyrp1
peptidoglycan recognition protein 1
chrX_-_7188713 2.815 ENSMUST00000004428.7
 Clcn5
chloride channel 5
chr13_+_37345338 2.793 ENSMUST00000021860.5
 Ly86
lymphocyte antigen 86
chr11_+_101246960 2.438 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr5_+_75152274 2.408 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr2_+_155940728 2.379 ENSMUST00000109629.1
 Gm15557
predicted gene 15557
chr6_-_126939524 2.351 ENSMUST00000144954.1
ENSMUST00000112221.1
ENSMUST00000112220.1
 Rad51ap1


RAD51 associated protein 1


chr10_-_53638269 2.332 ENSMUST00000164393.1
 Fam184a
family with sequence similarity 184, member A
chr13_+_83738874 2.323 ENSMUST00000052354.4
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr19_+_11518493 2.248 ENSMUST00000025580.3
 Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr6_+_125552948 2.237 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr6_-_119467210 2.230 ENSMUST00000118120.1
 Wnt5b
wingless-related MMTV integration site 5B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0006397 mRNA processing(GO:0006397)
0.4 5.8 GO:0018149 peptide cross-linking(GO:0018149)
0.2 5.0 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 3.8 GO:0030168 platelet activation(GO:0030168)
0.9 3.6 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
1.1 3.4 GO:0031117 serotonin receptor signaling pathway(GO:0007210) positive regulation of microtubule depolymerization(GO:0031117)
0.3 3.4 GO:0061032 visceral serous pericardium development(GO:0061032)
0.2 3.0 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.5 2.9 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.3 2.9 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.3 2.8 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.1 2.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.4 2.5 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.0 2.5 GO:0017145 stem cell division(GO:0017145)
0.8 2.4 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.2 2.4 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 2.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.7 2.1 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
0.7 2.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.7 2.0 GO:0014826 vein smooth muscle contraction(GO:0014826)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 GO:0072562 blood microparticle(GO:0072562)
0.0 5.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
1.2 3.6 GO:0044299 C-fiber(GO:0044299)
0.2 3.4 GO:0043203 axon hillock(GO:0043203)
0.1 3.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.6 3.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 3.1 GO:0031985 Golgi cisterna(GO:0031985)
0.2 3.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.8 2.5 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 2.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.3 GO:0005902 microvillus(GO:0005902)
0.4 2.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 2.2 GO:0030175 filopodium(GO:0030175)
0.4 2.1 GO:1990357 terminal web(GO:1990357)
0.5 2.0 GO:0032280 symmetric synapse(GO:0032280)
0.3 2.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 2.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.7 GO:0071439 clathrin complex(GO:0071439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 5.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 4.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.9 3.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.9 3.4 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin binding(GO:0051378) serotonin receptor activity(GO:0099589)
0.1 3.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 3.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.6 2.9 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 2.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 2.6 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.6 2.5 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.1 2.5 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.4 GO:0015026 coreceptor activity(GO:0015026)
0.1 2.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 2.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.7 2.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 2.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 2.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.5 2.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.3 2.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 2.1 GO:0039706 co-receptor binding(GO:0039706)