Motif ID: Foxd2

Z-value: 0.518


Transcription factors associated with Foxd2:

Gene SymbolEntrez IDGene Name
Foxd2 ENSMUSG00000055210.3 Foxd2



Activity profile for motif Foxd2.

activity profile for motif Foxd2


Sorted Z-values histogram for motif Foxd2

Sorted Z-values for motif Foxd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_14562171 0.810 ENSMUST00000181796.1
Vmn1r90
vomeronasal 1 receptor 90
chr1_-_157256682 0.716 ENSMUST00000134543.1
Rasal2
RAS protein activator like 2
chr18_+_37513652 0.629 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr4_-_14621805 0.624 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr1_-_126830786 0.611 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr10_-_11080956 0.582 ENSMUST00000105560.1
Grm1
glutamate receptor, metabotropic 1
chr13_+_16014457 0.560 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr10_+_67096456 0.549 ENSMUST00000174317.1
Jmjd1c
jumonji domain containing 1C
chr12_-_101958148 0.512 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
Atxn3



ataxin 3



chr6_+_13069758 0.500 ENSMUST00000124234.1
ENSMUST00000142211.1
ENSMUST00000031556.7
Tmem106b


transmembrane protein 106B


chr4_-_82850721 0.495 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr15_+_92597104 0.465 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr4_+_115737738 0.451 ENSMUST00000106525.2
Efcab14
EF-hand calcium binding domain 14
chr18_+_51117754 0.430 ENSMUST00000116639.2
Prr16
proline rich 16
chrX_+_159697308 0.426 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chr16_+_43508118 0.410 ENSMUST00000114690.1
Zbtb20
zinc finger and BTB domain containing 20
chr9_-_95750335 0.408 ENSMUST00000053785.3
Trpc1
transient receptor potential cation channel, subfamily C, member 1
chr2_-_45110336 0.407 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr9_+_14276301 0.402 ENSMUST00000034507.7
Sesn3
sestrin 3
chrX_-_105929206 0.396 ENSMUST00000134381.1
ENSMUST00000154866.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr19_-_31765027 0.395 ENSMUST00000065067.6
Prkg1
protein kinase, cGMP-dependent, type I
chr16_-_16527364 0.384 ENSMUST00000069284.7
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr1_-_37496095 0.382 ENSMUST00000148047.1
ENSMUST00000143636.1
Mgat4a

mannoside acetylglucosaminyltransferase 4, isoenzyme A

chr1_-_126830632 0.376 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr6_+_136518820 0.352 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr18_+_73863672 0.348 ENSMUST00000134847.1
Mro
maestro
chr4_+_115737754 0.329 ENSMUST00000106522.2
Efcab14
EF-hand calcium binding domain 14
chrX_-_105929333 0.315 ENSMUST00000134507.1
ENSMUST00000137453.1
ENSMUST00000150914.1
Atrx


alpha thalassemia/mental retardation syndrome X-linked homolog (human)


chr10_+_93488766 0.312 ENSMUST00000129421.1
Hal
histidine ammonia lyase
chr14_-_70630149 0.309 ENSMUST00000022694.9
Dmtn
dematin actin binding protein
chr11_+_97801917 0.296 ENSMUST00000127033.2
Lasp1
LIM and SH3 protein 1
chr13_+_5861489 0.292 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr16_+_43235856 0.286 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr13_-_97747373 0.269 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr2_-_73312701 0.265 ENSMUST00000058615.9
Cir1
corepressor interacting with RBPJ, 1
chr5_-_103100054 0.246 ENSMUST00000112848.1
Mapk10
mitogen-activated protein kinase 10
chr10_-_127030789 0.242 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chr11_+_43682038 0.237 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr5_+_148265202 0.235 ENSMUST00000110515.2
Mtus2
microtubule associated tumor suppressor candidate 2
chr6_+_38918969 0.230 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr9_+_78109188 0.215 ENSMUST00000118869.1
ENSMUST00000125615.1
Ick

intestinal cell kinase

chr1_-_170867761 0.196 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr9_+_105642957 0.185 ENSMUST00000065778.6
Pik3r4
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr5_+_107497762 0.179 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr11_+_98798653 0.175 ENSMUST00000037930.6
Msl1
male-specific lethal 1 homolog (Drosophila)
chr4_-_14621669 0.168 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr10_+_37139558 0.166 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr14_-_52213379 0.164 ENSMUST00000140603.1
Chd8
chromodomain helicase DNA binding protein 8
chr17_+_29090969 0.161 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_-_122702615 0.161 ENSMUST00000005952.4
ENSMUST00000099457.3
Slc30a4

solute carrier family 30 (zinc transporter), member 4

chr15_+_100154379 0.156 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr15_-_44428303 0.151 ENSMUST00000038719.6
Nudcd1
NudC domain containing 1
chr3_+_102010138 0.142 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr14_+_101840501 0.135 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr5_+_148265307 0.135 ENSMUST00000110514.1
Mtus2
microtubule associated tumor suppressor candidate 2
chr6_+_77242644 0.129 ENSMUST00000159616.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr11_+_75650501 0.129 ENSMUST00000102505.3
Myo1c
myosin IC
chr7_+_43634718 0.126 ENSMUST00000032663.8
Ceacam18
carcinoembryonic antigen-related cell adhesion molecule 18
chr5_+_148265265 0.124 ENSMUST00000071878.5
Mtus2
microtubule associated tumor suppressor candidate 2
chr7_-_133015248 0.115 ENSMUST00000169570.1
Ctbp2
C-terminal binding protein 2
chr16_+_13986596 0.114 ENSMUST00000056521.5
ENSMUST00000118412.1
ENSMUST00000131608.1
2900011O08Rik


RIKEN cDNA 2900011O08 gene


chr6_+_11926758 0.110 ENSMUST00000133776.1
Phf14
PHD finger protein 14
chr5_+_121795034 0.109 ENSMUST00000162327.1
Atxn2
ataxin 2
chr19_-_29753600 0.105 ENSMUST00000175764.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr1_-_165934900 0.104 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr14_+_80000292 0.100 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr9_+_54980880 0.096 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr6_+_77242715 0.095 ENSMUST00000161677.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr1_+_109993982 0.094 ENSMUST00000027542.6
Cdh7
cadherin 7, type 2
chr7_-_99980431 0.090 ENSMUST00000080817.4
Rnf169
ring finger protein 169
chr5_+_107497718 0.085 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr3_+_89520152 0.083 ENSMUST00000000811.7
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr14_-_30353468 0.068 ENSMUST00000112249.1
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr5_-_88675190 0.065 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr1_-_132367879 0.063 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr4_+_150087365 0.062 ENSMUST00000094451.3
Gpr157
G protein-coupled receptor 157
chr9_+_52047150 0.062 ENSMUST00000163153.1
Rdx
radixin
chr15_-_98607611 0.052 ENSMUST00000096224.4
Adcy6
adenylate cyclase 6
chr1_+_171840607 0.045 ENSMUST00000136479.1
ENSMUST00000042302.6
Cd84

CD84 antigen

chr2_+_152669461 0.043 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
H13



histocompatibility 13



chr6_-_54972603 0.036 ENSMUST00000060655.8
Nod1
nucleotide-binding oligomerization domain containing 1
chr17_-_35046726 0.033 ENSMUST00000097338.4
Msh5
mutS homolog 5 (E. coli)
chr9_-_90270712 0.026 ENSMUST00000041767.7
ENSMUST00000144348.1
Tbc1d2b

TBC1 domain family, member 2B

chr14_+_26259109 0.017 ENSMUST00000174494.1
Duxbl3
double homeobox B-like 3
chr1_-_44102341 0.012 ENSMUST00000128190.1
Tex30
testis expressed 30
chr7_-_61982290 0.012 ENSMUST00000180481.1
A330076H08Rik
RIKEN cDNA A330076H08 gene
chr10_-_89621253 0.012 ENSMUST00000020102.7
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr5_-_104114088 0.007 ENSMUST00000031249.3
Sparcl1
SPARC-like 1
chr12_-_52006490 0.004 ENSMUST00000085404.3
ENSMUST00000021339.7
Dtd2

D-tyrosyl-tRNA deacylase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1 0.4 GO:2000224 testosterone biosynthetic process(GO:0061370) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.8 GO:0019532 oxalate transport(GO:0019532)
0.1 0.6 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 0.3 GO:1901731 calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731)
0.1 0.5 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.3 GO:0006547 histidine metabolic process(GO:0006547)
0.1 0.4 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.5 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.6 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.4 GO:0030035 microspike assembly(GO:0030035)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.4 GO:0046541 saliva secretion(GO:0046541)
0.0 0.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0 0.4 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0035811 negative regulation of urine volume(GO:0035811)
0.0 0.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.2 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0021814 cell motility involved in cerebral cortex radial glia guided migration(GO:0021814)
0.0 0.2 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.2 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.0 GO:2001180 negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180)
0.0 0.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.0 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.0 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0043512 inhibin A complex(GO:0043512)
0.2 0.7 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 0.6 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1 0.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0045160 myosin I complex(GO:0045160)
0.0 0.4 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.5 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.2 GO:0097542 ciliary tip(GO:0097542)
0.0 0.4 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639)
0.1 0.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.4 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.7 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.5 GO:0018602 sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)