Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.880

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrx1mm10_v2_chr1_-_163313661_1633137100.117.2e-01Click!
Prrxl1mm10_v2_chr14_+_32599922_325999320.029.4e-01Click!


Activity profile for motif Prrx1_Isx_Prrxl1.

activity profile for motif Prrx1_Isx_Prrxl1


Sorted Z-values histogram for motif Prrx1_Isx_Prrxl1

Sorted Z-values for motif Prrx1_Isx_Prrxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_118478344 2.930 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 2.717 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr18_-_66860458 2.313 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr2_-_72986716 1.668 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr2_+_61804453 0.978 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr11_-_59163281 0.864 ENSMUST00000069631.2
 Iba57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr18_-_13972617 0.828 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr2_+_155751117 0.817 ENSMUST00000029140.5
ENSMUST00000132608.1
 Procr

protein C receptor, endothelial

chr4_-_155645408 0.748 ENSMUST00000115821.2
 Gm10563
predicted gene 10563
chr1_-_24005608 0.723 ENSMUST00000027338.3
 1110058L19Rik
RIKEN cDNA 1110058L19 gene
chrM_+_11734 0.719 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr17_+_27556668 0.694 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chr10_+_41490436 0.689 ENSMUST00000105507.3
 Ppil6
peptidylprolyl isomerase (cyclophilin)-like 6
chr17_+_27556641 0.672 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr8_-_106573461 0.661 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr2_+_116067213 0.656 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr18_-_78206408 0.631 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr4_+_5724304 0.630 ENSMUST00000108380.1
 Fam110b
family with sequence similarity 110, member B
chr17_+_27556613 0.595 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr13_+_104229366 0.585 ENSMUST00000022227.6
 Cenpk
centromere protein K

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 2.3 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0 2.0 GO:0006284 base-excision repair(GO:0006284)
0.0 1.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 1.4 GO:0021764 amygdala development(GO:0021764)
0.1 1.1 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.8 GO:0050819 negative regulation of coagulation(GO:0050819)
0.2 0.6 GO:2000338 positive regulation of interleukin-23 production(GO:0032747) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.1 0.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.6 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2 0.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 0.5 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.5 GO:0046549 retinal cone cell development(GO:0046549)
0.1 0.5 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.0 0.5 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0 0.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0070469 respiratory chain(GO:0070469)
0.3 2.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.6 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.5 GO:0002177 manchette(GO:0002177)
0.0 0.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.2 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.8 2.3 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 2.0 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 0.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 0.6 GO:0070976 TIR domain binding(GO:0070976)
0.1 0.6 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.6 GO:0000150 recombinase activity(GO:0000150)
0.1 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 0.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.5 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.5 GO:0015265 urea channel activity(GO:0015265)
0.0 0.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.3 GO:0042556 cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)