Motif ID: Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 0.690

Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6:

Gene SymbolEntrez IDGene Name
Barx1 ENSMUSG00000021381.4 Barx1
Dlx6 ENSMUSG00000029754.7 Dlx6
Lhx9 ENSMUSG00000019230.8 Lhx9
Msx1 ENSMUSG00000048450.10 Msx1
Rax ENSMUSG00000024518.3 Rax

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Raxmm10_v2_chr18_-_65939048_65939089-0.283.4e-01Click!
Dlx6mm10_v2_chr6_+_6863269_6863334-0.214.8e-01Click!
Lhx9mm10_v2_chr1_-_138842429_1388424570.087.8e-01Click!
Msx1mm10_v2_chr5_-_37824580_37824584-0.068.3e-01Click!


Activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6.

activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6


Sorted Z-values histogram for motif Msx1_Lhx9_Barx1_Rax_Dlx6

Sorted Z-values for motif Msx1_Lhx9_Barx1_Rax_Dlx6



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Top targets:


Showing 1 to 20 of 197 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_118478344 6.946 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 6.634 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr1_-_155417394 2.991 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr19_-_14597983 2.672 ENSMUST00000052011.7
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_-_14598031 2.646 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr10_+_99263224 2.510 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr6_+_15196949 2.267 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr1_-_155417283 2.011 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr1_-_79440039 1.446 ENSMUST00000049972.4
 Scg2
secretogranin II
chr12_-_83487708 1.272 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr2_+_20737306 1.235 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr2_-_72986716 1.134 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr17_+_17402672 1.105 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr15_-_13173607 1.039 ENSMUST00000036439.4
 Cdh6
cadherin 6
chr11_+_102604370 1.024 ENSMUST00000057893.5
 Fzd2
frizzled homolog 2 (Drosophila)
chr14_-_118052235 0.973 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr11_-_87359011 0.959 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr13_-_56252163 0.952 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr6_-_138421379 0.944 ENSMUST00000163065.1
 Lmo3
LIM domain only 3
chr6_-_126645784 0.930 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 13.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.8 5.0 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 4.8 GO:0016055 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
0.8 2.5 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 2.3 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 2.0 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.3 1.6 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.3 1.4 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 1.3 GO:0098792 xenophagy(GO:0098792)
0.0 1.1 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.1 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.2 1.0 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 1.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 1.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 1.0 GO:0006284 base-excision repair(GO:0006284)
0.3 0.9 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.9 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.2 0.7 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.2 0.7 GO:0061055 myotome development(GO:0061055)
0.0 0.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0097440 apical dendrite(GO:0097440)
0.1 1.4 GO:0031045 dense core granule(GO:0031045)
0.1 1.4 GO:0071565 nBAF complex(GO:0071565)
0.1 1.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.5 GO:0060187 cell pole(GO:0060187)
0.1 0.4 GO:0031523 Myb complex(GO:0031523)
0.1 0.3 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 5.7 GO:0070491 repressing transcription factor binding(GO:0070491)
0.6 5.0 GO:0001618 virus receptor activity(GO:0001618)
0.1 2.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 2.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.6 GO:0042056 chemoattractant activity(GO:0042056)
0.1 1.0 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 1.0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 1.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.7 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)