Motif ID: Nkx2-6

Z-value: 0.305


Transcription factors associated with Nkx2-6:

Gene SymbolEntrez IDGene Name
Nkx2-6 ENSMUSG00000044186.9 Nkx2-6



Activity profile for motif Nkx2-6.

activity profile for motif Nkx2-6


Sorted Z-values histogram for motif Nkx2-6

Sorted Z-values for motif Nkx2-6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_62619515 0.553 ENSMUST00000084521.4
ENSMUST00000107424.1
 Rgs3

regulator of G-protein signaling 3

chr10_+_52358767 0.353 ENSMUST00000180473.1
 Gm26741
predicted gene, 26741
chr9_-_10904766 0.289 ENSMUST00000160216.1
 Cntn5
contactin 5
chr11_+_103774150 0.287 ENSMUST00000000127.5
 Wnt3
wingless-related MMTV integration site 3
chr9_-_10904697 0.259 ENSMUST00000162484.1
 Cntn5
contactin 5
chr1_+_179960472 0.192 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr1_+_179961110 0.171 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr17_-_45599603 0.155 ENSMUST00000171847.1
ENSMUST00000166633.1
ENSMUST00000169729.1
 Slc29a1


solute carrier family 29 (nucleoside transporters), member 1


chr3_+_62419668 0.151 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr7_-_116237767 0.147 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr4_-_91399984 0.111 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr5_+_110330697 0.075 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr2_-_147186389 0.063 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr19_+_8819401 0.060 ENSMUST00000096753.3
 Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr19_+_8802486 0.044 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3
chr2_+_23069210 0.043 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr5_-_90223923 0.038 ENSMUST00000118816.1
ENSMUST00000048363.7
 Cox18

cytochrome c oxidase assembly protein 18

chr10_+_100488289 0.028 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr4_-_109665249 0.028 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr6_+_70726430 0.023 ENSMUST00000103410.1
 Igkc
immunoglobulin kappa constant
chr2_-_121456693 0.011 ENSMUST00000110613.2
ENSMUST00000056312.3
 Serinc4

serine incorporator 4

chr1_-_156034826 0.001 ENSMUST00000141878.1
ENSMUST00000123705.1
 Tor1aip1

torsin A interacting protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.4 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)