Motif ID: Elf3

Z-value: 1.738


Transcription factors associated with Elf3:

Gene SymbolEntrez IDGene Name
Elf3 ENSMUSG00000003051.7 Elf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf3mm10_v2_chr1_-_135258449_1352584720.293.1e-01Click!


Activity profile for motif Elf3.

activity profile for motif Elf3


Sorted Z-values histogram for motif Elf3

Sorted Z-values for motif Elf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_169685191 10.484 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr5_+_17574268 7.930 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_+_61653259 5.177 ENSMUST00000004959.2
 Grap
GRB2-related adaptor protein
chr5_-_43981757 4.775 ENSMUST00000061299.7
 Fgfbp1
fibroblast growth factor binding protein 1
chr14_-_70207637 4.686 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr10_-_83648713 4.574 ENSMUST00000020500.7
 Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr4_-_53159885 3.904 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr11_-_55419898 3.891 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr8_+_66386292 3.452 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr11_+_115163333 3.429 ENSMUST00000021077.3
 Slc9a3r1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr13_-_103920508 2.989 ENSMUST00000053927.5
ENSMUST00000091269.4
ENSMUST00000022222.5
 Erbb2ip


Erbb2 interacting protein


chr17_+_86753900 2.840 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr1_-_128592284 2.833 ENSMUST00000052172.6
ENSMUST00000142893.1
 Cxcr4

chemokine (C-X-C motif) receptor 4

chr8_+_104340594 2.713 ENSMUST00000034343.4
 Cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr6_+_29694204 2.653 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr13_-_103920295 2.506 ENSMUST00000169083.1
 Erbb2ip
Erbb2 interacting protein
chr11_-_118401826 2.471 ENSMUST00000106290.3
ENSMUST00000043722.3
 Lgals3bp

lectin, galactoside-binding, soluble, 3 binding protein

chr11_-_48816936 2.428 ENSMUST00000140800.1
 Trim41
tripartite motif-containing 41
chr4_-_118489755 2.418 ENSMUST00000184261.1
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr14_-_57890242 2.399 ENSMUST00000089473.3
 Zdhhc20
zinc finger, DHHC domain containing 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
1.1 7.9 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
1.4 5.5 GO:0070425 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433)
0.1 4.9 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.6 4.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
1.0 3.9 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489) platelet dense granule organization(GO:0060155)
0.1 3.9 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.2 3.5 GO:0001553 luteinization(GO:0001553)
0.2 3.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
1.1 3.4 GO:0042939 renal sodium ion transport(GO:0003096) glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
1.1 3.3 GO:0060913 stem cell fate specification(GO:0048866) cardiac cell fate determination(GO:0060913) regulation of cardiac cell fate specification(GO:2000043)
1.0 3.0 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.4 2.9 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.9 2.8 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.7 2.8 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.5 2.7 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 2.7 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.5 2.4 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 2.4 GO:0045026 plasma membrane fusion(GO:0045026)
0.1 2.4 GO:0018345 protein palmitoylation(GO:0018345)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.5 GO:0005615 extracellular space(GO:0005615)
0.0 8.4 GO:0005874 microtubule(GO:0005874)
0.2 6.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 5.1 GO:0072562 blood microparticle(GO:0072562)
0.2 4.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 4.0 GO:0009986 cell surface(GO:0009986)
1.0 3.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 3.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 3.7 GO:0005667 transcription factor complex(GO:0005667)
0.7 3.4 GO:0032426 stereocilium tip(GO:0032426)
1.0 2.9 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 2.9 GO:0005769 early endosome(GO:0005769)
0.0 2.8 GO:0030141 secretory granule(GO:0030141)
0.4 2.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 2.6 GO:0031526 brush border membrane(GO:0031526)
0.2 2.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 2.4 GO:0005901 caveola(GO:0005901)
0.0 2.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 2.3 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.2 GO:0000776 kinetochore(GO:0000776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.7 7.9 GO:0038191 neuropilin binding(GO:0038191)
1.4 5.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 4.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 4.2 GO:0017166 vinculin binding(GO:0017166)
1.3 3.9 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.1 3.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 3.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 3.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.5 GO:0042287 MHC protein binding(GO:0042287)
0.4 3.4 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 3.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.7 2.9 GO:0035877 death effector domain binding(GO:0035877)
0.9 2.8 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 2.8 GO:0050897 cobalt ion binding(GO:0050897)
0.1 2.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 2.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 2.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)