Motif ID: Atf4

Z-value: 1.070


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.117.1e-01Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_103422010 6.692 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr19_-_12501996 2.224 ENSMUST00000045521.7
Dtx4
deltex 4 homolog (Drosophila)
chr5_-_3473178 1.772 ENSMUST00000168422.1
Gm17590
predicted gene, 17590
chr4_+_117835387 1.234 ENSMUST00000169885.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr10_-_83533383 1.175 ENSMUST00000146640.1
Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr5_-_148399901 1.091 ENSMUST00000048116.8
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr11_-_75422524 1.058 ENSMUST00000125982.1
ENSMUST00000137103.1
Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr7_-_126625676 1.033 ENSMUST00000032961.3
Nupr1
nuclear protein transcription regulator 1
chr8_+_75093591 1.019 ENSMUST00000005548.6
Hmox1
heme oxygenase (decycling) 1
chr10_-_68278713 0.922 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr4_+_42735545 0.890 ENSMUST00000068158.3
4930578G10Rik
RIKEN cDNA 4930578G10 gene
chr12_+_85599388 0.777 ENSMUST00000050687.6
Jdp2
Jun dimerization protein 2
chr4_+_46450892 0.711 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr11_-_20332689 0.683 ENSMUST00000109594.1
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr12_+_85599047 0.680 ENSMUST00000177587.1
Jdp2
Jun dimerization protein 2
chr11_-_20332654 0.661 ENSMUST00000004634.6
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr6_-_97459279 0.619 ENSMUST00000113359.1
Frmd4b
FERM domain containing 4B
chr4_-_129189600 0.585 ENSMUST00000117497.1
ENSMUST00000117350.1
S100pbp

S100P binding protein

chr11_-_101171302 0.571 ENSMUST00000164474.1
ENSMUST00000043397.7
Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr6_-_129533267 0.555 ENSMUST00000181594.1
1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr7_+_144896523 0.550 ENSMUST00000033389.5
Fgf15
fibroblast growth factor 15
chr19_-_50678642 0.519 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chr3_+_89715016 0.457 ENSMUST00000098924.2
Adar
adenosine deaminase, RNA-specific
chr15_+_82147238 0.454 ENSMUST00000023100.6
Srebf2
sterol regulatory element binding factor 2
chr8_+_117157972 0.440 ENSMUST00000064488.4
ENSMUST00000162997.1
Gan

giant axonal neuropathy

chr7_-_143600049 0.431 ENSMUST00000105909.3
ENSMUST00000010899.7
Cars

cysteinyl-tRNA synthetase

chr4_+_41942037 0.413 ENSMUST00000181518.1
Gm20878
predicted gene, 20878
chr9_+_109931863 0.412 ENSMUST00000165876.1
Map4
microtubule-associated protein 4
chr12_-_104865076 0.398 ENSMUST00000109937.1
ENSMUST00000109936.1
Clmn

calmin

chr4_+_124741844 0.385 ENSMUST00000094782.3
ENSMUST00000153837.1
ENSMUST00000154229.1
Inpp5b


inositol polyphosphate-5-phosphatase B


chr7_+_44468051 0.377 ENSMUST00000118493.1
Josd2
Josephin domain containing 2
chr19_-_40588374 0.376 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
Aldh18a1


aldehyde dehydrogenase 18 family, member A1


chr19_-_15924928 0.353 ENSMUST00000025542.3
Psat1
phosphoserine aminotransferase 1
chr9_+_109931458 0.340 ENSMUST00000072772.5
ENSMUST00000035055.8
Map4

microtubule-associated protein 4

chr18_-_42262053 0.339 ENSMUST00000097590.3
Lars
leucyl-tRNA synthetase
chr2_+_163995503 0.336 ENSMUST00000131288.1
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr19_+_44203265 0.320 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr5_-_31179901 0.295 ENSMUST00000101411.2
ENSMUST00000140793.1
Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr1_-_22315792 0.286 ENSMUST00000164877.1
Rims1
regulating synaptic membrane exocytosis 1
chr7_+_125603420 0.258 ENSMUST00000033000.6
Il21r
interleukin 21 receptor
chr18_-_64516547 0.258 ENSMUST00000025483.9
Nars
asparaginyl-tRNA synthetase
chr10_+_121739915 0.253 ENSMUST00000065600.7
ENSMUST00000136432.1
BC048403

cDNA sequence BC048403

chr14_-_69284982 0.247 ENSMUST00000183882.1
ENSMUST00000037064.4
Slc25a37

solute carrier family 25, member 37

chr15_-_98953541 0.236 ENSMUST00000097014.5
Tuba1a
tubulin, alpha 1A
chr19_-_40588338 0.225 ENSMUST00000176939.1
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr14_+_55540266 0.217 ENSMUST00000048781.3
Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr7_+_44468020 0.210 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josd2


Josephin domain containing 2


chr19_-_40588453 0.199 ENSMUST00000025979.6
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr5_-_31180110 0.195 ENSMUST00000043161.6
ENSMUST00000088010.5
Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr6_+_113483297 0.192 ENSMUST00000032422.5
Creld1
cysteine-rich with EGF-like domains 1
chr3_-_127409014 0.191 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
Ank2


ankyrin 2, brain


chr2_+_119351222 0.190 ENSMUST00000028780.3
Chac1
ChaC, cation transport regulator 1
chr10_-_127311740 0.188 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chr3_-_138143352 0.186 ENSMUST00000098580.2
Mttp
microsomal triglyceride transfer protein
chr11_-_120643643 0.184 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1




pyrroline-5-carboxylate reductase 1




chr2_+_3513035 0.183 ENSMUST00000036350.2
Cdnf
cerebral dopamine neurotrophic factor
chr7_-_126566364 0.181 ENSMUST00000032992.5
Eif3c
eukaryotic translation initiation factor 3, subunit C
chr7_+_44467980 0.181 ENSMUST00000035844.4
Josd2
Josephin domain containing 2
chr8_+_111033890 0.181 ENSMUST00000034441.7
Aars
alanyl-tRNA synthetase
chrX_-_162565514 0.176 ENSMUST00000154424.1
Reps2
RALBP1 associated Eps domain containing protein 2
chr7_-_61311679 0.173 ENSMUST00000107533.3
ENSMUST00000154958.1
A230006K03Rik

RIKEN cDNA A230006K03 gene

chr15_+_99393219 0.169 ENSMUST00000159209.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr5_-_36695969 0.160 ENSMUST00000031091.9
ENSMUST00000140063.1
D5Ertd579e

DNA segment, Chr 5, ERATO Doi 579, expressed

chr4_-_129189512 0.159 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
S100pbp


S100P binding protein


chr3_-_127408937 0.159 ENSMUST00000183095.1
ENSMUST00000182610.1
Ank2

ankyrin 2, brain

chr10_-_127522428 0.159 ENSMUST00000026470.4
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr11_-_35798884 0.154 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr1_+_133131143 0.151 ENSMUST00000052529.3
Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr6_-_83317589 0.140 ENSMUST00000005810.6
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr7_-_126502312 0.138 ENSMUST00000166682.2
Atxn2l
ataxin 2-like
chr1_+_185363076 0.135 ENSMUST00000046514.7
Eprs
glutamyl-prolyl-tRNA synthetase
chr8_-_122476036 0.133 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr13_+_49682191 0.132 ENSMUST00000172254.1
Iars
isoleucine-tRNA synthetase
chr8_-_105701077 0.102 ENSMUST00000042608.6
Acd
adrenocortical dysplasia
chr7_-_138846202 0.101 ENSMUST00000118810.1
ENSMUST00000075667.4
ENSMUST00000119664.1
Mapk1ip1


mitogen-activated protein kinase 1 interacting protein 1


chr7_-_126502094 0.101 ENSMUST00000179818.1
Atxn2l
ataxin 2-like
chr7_+_138846579 0.100 ENSMUST00000155672.1
Ppp2r2d
protein phosphatase 2, regulatory subunit B, delta isoform
chr14_-_66868572 0.095 ENSMUST00000022629.8
Dpysl2
dihydropyrimidinase-like 2
chr3_+_138143483 0.091 ENSMUST00000162864.1
Trmt10a
tRNA methyltransferase 10A
chr11_-_118290167 0.078 ENSMUST00000144153.1
Usp36
ubiquitin specific peptidase 36
chr5_-_90223923 0.077 ENSMUST00000118816.1
ENSMUST00000048363.7
Cox18

cytochrome c oxidase assembly protein 18

chr4_-_139380374 0.077 ENSMUST00000181556.1
2700016F22Rik
RIKEN cDNA 2700016F22 gene
chr14_-_37135126 0.069 ENSMUST00000042564.9
Ghitm
growth hormone inducible transmembrane protein
chr4_+_129189760 0.065 ENSMUST00000106054.2
ENSMUST00000001365.2
Yars

tyrosyl-tRNA synthetase

chr1_-_180193475 0.065 ENSMUST00000160482.1
ENSMUST00000170472.1
Adck3

aarF domain containing kinase 3

chr8_+_25808474 0.060 ENSMUST00000033979.4
Star
steroidogenic acute regulatory protein
chr1_-_170110491 0.055 ENSMUST00000027985.2
Ddr2
discoidin domain receptor family, member 2
chr8_+_123477859 0.055 ENSMUST00000001520.7
Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr4_-_118179628 0.055 ENSMUST00000097911.2
Kdm4a
lysine (K)-specific demethylase 4A
chr3_+_138143429 0.053 ENSMUST00000040321.6
Trmt10a
tRNA methyltransferase 10A
chr7_-_126502380 0.052 ENSMUST00000167759.1
Atxn2l
ataxin 2-like
chr13_-_101692624 0.052 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr10_+_80141457 0.051 ENSMUST00000105367.1
Atp5d
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr13_-_118387224 0.041 ENSMUST00000022245.8
Mrps30
mitochondrial ribosomal protein S30
chr4_-_129189646 0.031 ENSMUST00000106059.1
S100pbp
S100P binding protein
chr8_-_92356103 0.030 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr19_-_4793851 0.029 ENSMUST00000178615.1
ENSMUST00000179189.1
ENSMUST00000164376.2
ENSMUST00000164209.2
ENSMUST00000180248.1
Rbm4




RNA binding motif protein 4




chr1_-_78488846 0.016 ENSMUST00000068333.7
ENSMUST00000170217.1
Farsb

phenylalanyl-tRNA synthetase, beta subunit

chr8_+_85492568 0.014 ENSMUST00000034136.5
Gpt2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr11_+_100320596 0.011 ENSMUST00000152521.1
Eif1
eukaryotic translation initiation factor 1
chr15_+_99393610 0.011 ENSMUST00000159531.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr11_-_87826023 0.010 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr4_-_41774097 0.010 ENSMUST00000108036.1
ENSMUST00000173865.1
ENSMUST00000108037.2
ENSMUST00000108032.2
Ccl27a



chemokine (C-C motif) ligand 27A



chr15_+_99393574 0.009 ENSMUST00000162624.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr16_-_34095983 0.008 ENSMUST00000114973.1
ENSMUST00000114964.1
Kalrn

kalirin, RhoGEF kinase

chr19_-_43524462 0.003 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr6_+_55037988 0.002 ENSMUST00000003572.8
Gars
glycyl-tRNA synthetase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.4 1.2 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.3 1.0 GO:1904706 response to cisplatin(GO:0072718) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.3 0.8 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.2 1.3 GO:0015808 L-alanine transport(GO:0015808)
0.2 1.1 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.2 0.5 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1 0.6 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 1.0 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 0.9 GO:0060613 fat pad development(GO:0060613)
0.1 0.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.5 GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368)
0.1 0.3 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.2 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.3 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 1.5 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.1 0.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.5 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.2 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.2 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 0.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 1.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.2 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 2.4 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.1 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.5 GO:0043203 axon hillock(GO:0043203)
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.1 GO:0070187 telosome(GO:0070187)
0.0 0.1 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.3 0.8 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.3 1.0 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.2 1.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 1.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 1.1 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.2 0.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 0.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.3 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.1 0.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.2 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.1 0.2 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 0.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.3 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.8 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 1.1 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 1.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)