Motif ID: Atf4

Z-value: 1.070


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.117.1e-01Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 107 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 6.692 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr19_-_12501996 2.224 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr5_-_3473178 1.772 ENSMUST00000168422.1
 Gm17590
predicted gene, 17590
chr4_+_117835387 1.234 ENSMUST00000169885.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr10_-_83533383 1.175 ENSMUST00000146640.1
 Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr5_-_148399901 1.091 ENSMUST00000048116.8
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr11_-_75422524 1.058 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr7_-_126625676 1.033 ENSMUST00000032961.3
 Nupr1
nuclear protein transcription regulator 1
chr8_+_75093591 1.019 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr10_-_68278713 0.922 ENSMUST00000020106.7
 Arid5b
AT rich interactive domain 5B (MRF1-like)
chr4_+_42735545 0.890 ENSMUST00000068158.3
 4930578G10Rik
RIKEN cDNA 4930578G10 gene
chr12_+_85599388 0.777 ENSMUST00000050687.6
 Jdp2
Jun dimerization protein 2
chr4_+_46450892 0.711 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr11_-_20332689 0.683 ENSMUST00000109594.1
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr12_+_85599047 0.680 ENSMUST00000177587.1
 Jdp2
Jun dimerization protein 2
chr11_-_20332654 0.661 ENSMUST00000004634.6
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr6_-_97459279 0.619 ENSMUST00000113359.1
 Frmd4b
FERM domain containing 4B
chr4_-_129189600 0.585 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr11_-_101171302 0.571 ENSMUST00000164474.1
ENSMUST00000043397.7
 Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr6_-_129533267 0.555 ENSMUST00000181594.1
 1700101I11Rik
RIKEN cDNA 1700101I11 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0007219 Notch signaling pathway(GO:0007219)
0.1 1.5 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.2 1.3 GO:0015808 L-alanine transport(GO:0015808)
0.4 1.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.4 1.2 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.2 1.1 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0 1.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.3 1.0 GO:1904706 response to cisplatin(GO:0072718) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 1.0 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 0.9 GO:0060613 fat pad development(GO:0060613)
0.3 0.8 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 0.7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 0.6 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 0.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 0.5 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 0.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.5 GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368)
0.1 0.5 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.5 GO:0043203 axon hillock(GO:0043203)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.1 GO:0070187 telosome(GO:0070187)
0.0 0.1 GO:0005745 m-AAA complex(GO:0005745)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.4 1.2 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.2 1.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 1.1 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0 1.1 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)
0.3 1.0 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.3 0.8 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.0 0.8 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 0.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 0.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.1 0.3 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.1 0.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 0.3 GO:0050815 phosphoserine binding(GO:0050815)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.2 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.1 0.2 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)