Motif ID: Nfe2l2

Z-value: 0.780


Transcription factors associated with Nfe2l2:

Gene SymbolEntrez IDGene Name
Nfe2l2 ENSMUSG00000015839.6 Nfe2l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfe2l2mm10_v2_chr2_-_75704535_757046410.381.8e-01Click!


Activity profile for motif Nfe2l2.

activity profile for motif Nfe2l2


Sorted Z-values histogram for motif Nfe2l2

Sorted Z-values for motif Nfe2l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 180 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_61639542 2.257 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr2_+_25395866 1.620 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr8_+_65967157 1.570 ENSMUST00000072482.6
 March1
membrane-associated ring finger (C3HC4) 1
chr17_-_24644933 1.328 ENSMUST00000019684.5
 Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr3_-_116968827 1.257 ENSMUST00000119557.1
 Palmd
palmdelphin
chr1_+_165769392 1.080 ENSMUST00000040298.4
 Creg1
cellular repressor of E1A-stimulated genes 1
chr17_-_25570678 1.061 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr3_-_116968969 0.967 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr4_+_116685859 0.932 ENSMUST00000129315.1
ENSMUST00000106470.1
 Prdx1

peroxiredoxin 1

chr6_+_17463927 0.916 ENSMUST00000115442.1
 Met
met proto-oncogene
chr4_+_116685544 0.806 ENSMUST00000135573.1
ENSMUST00000151129.1
 Prdx1

peroxiredoxin 1

chr19_-_4037910 0.739 ENSMUST00000169613.1
 Gstp1
glutathione S-transferase, pi 1
chr4_+_117251951 0.698 ENSMUST00000062824.5
 Tmem53
transmembrane protein 53
chr17_-_25868727 0.690 ENSMUST00000026828.5
 Fam195a
family with sequence similarity 195, member A
chr4_+_118961578 0.677 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr14_+_62292475 0.675 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chr15_-_79834261 0.674 ENSMUST00000148358.1
 Cbx6
chromobox 6
chr2_-_25272380 0.655 ENSMUST00000028342.6
 Ssna1
Sjogren's syndrome nuclear autoantigen 1
chr4_-_126321669 0.635 ENSMUST00000102617.4
 Adprhl2
ADP-ribosylhydrolase like 2
chr7_-_102250086 0.632 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.2 1.6 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.1 1.6 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 1.3 GO:0071635 negative regulation of transforming growth factor beta production(GO:0071635)
0.1 1.3 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.4 1.1 GO:0072034 renal vesicle induction(GO:0072034)
0.3 1.0 GO:0072180 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
0.0 0.8 GO:0032543 mitochondrial translation(GO:0032543)
0.2 0.7 GO:0070488 neutrophil aggregation(GO:0070488)
0.2 0.7 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 0.7 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 0.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.6 GO:0002934 desmosome organization(GO:0002934)
0.0 0.6 GO:0032620 interleukin-17 production(GO:0032620)
0.0 0.6 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 0.6 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 0.5 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 0.5 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.5 GO:0007412 axon target recognition(GO:0007412)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.6 GO:0005605 basal lamina(GO:0005605)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)
0.3 1.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.7 GO:0031595 nuclear proteasome complex(GO:0031595)
0.2 0.6 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.6 GO:0031045 dense core granule(GO:0031045)
0.2 0.5 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.5 GO:0070552 BRISC complex(GO:0070552)
0.1 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.4 GO:0036501 UFD1-NPL4 complex(GO:0036501)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 1.6 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 1.6 GO:0042287 MHC protein binding(GO:0042287)
0.1 1.3 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 1.1 GO:0010181 FMN binding(GO:0010181)
0.0 1.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 1.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 0.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 0.7 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 0.6 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.6 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.5 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)