Motif ID: Hoxb2_Dlx2

Z-value: 1.325

Transcription factors associated with Hoxb2_Dlx2:

Gene SymbolEntrez IDGene Name
Dlx2 ENSMUSG00000023391.7 Dlx2
Hoxb2 ENSMUSG00000075588.5 Hoxb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx2mm10_v2_chr2_-_71546745_715467580.851.4e-04Click!


Activity profile for motif Hoxb2_Dlx2.

activity profile for motif Hoxb2_Dlx2


Sorted Z-values histogram for motif Hoxb2_Dlx2

Sorted Z-values for motif Hoxb2_Dlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb2_Dlx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_42907563 9.172 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr1_-_190170671 7.167 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr5_-_62766153 6.721 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_71528657 6.647 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr15_-_11037968 6.416 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr1_+_104768510 5.996 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr2_+_125136692 5.689 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr2_-_77703252 5.629 ENSMUST00000171063.1
 Zfp385b
zinc finger protein 385B
chr12_+_38780284 4.983 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr6_+_125552948 4.789 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr2_-_164171113 4.761 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chr2_-_116067391 4.759 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr2_+_116067213 4.683 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr12_+_38783503 4.611 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr5_-_134747241 4.425 ENSMUST00000015138.9
 Eln
elastin
chr1_-_140183404 4.038 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chrM_+_7005 4.034 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr6_-_147264124 3.635 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr18_-_80986578 3.615 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr12_+_38780817 3.600 ENSMUST00000160856.1
 Etv1
ets variant gene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 10.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
3.4 10.1 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
3.3 9.9 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.1 8.1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 7.1 GO:0022900 electron transport chain(GO:0022900)
1.1 6.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.5 6.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 5.3 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 5.2 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 3.8 GO:0030168 platelet activation(GO:0030168)
0.5 3.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.4 3.6 GO:0043129 surfactant homeostasis(GO:0043129)
0.9 3.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 3.4 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.5 3.2 GO:0019532 oxalate transport(GO:0019532)
0.1 3.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 3.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.2 2.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.6 2.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.5 GO:0070469 respiratory chain(GO:0070469)
0.1 7.3 GO:0072562 blood microparticle(GO:0072562)
1.0 4.8 GO:0033093 Weibel-Palade body(GO:0033093)
1.5 4.4 GO:0071953 elastic fiber(GO:0071953)
0.1 4.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 3.5 GO:0043205 fibril(GO:0043205)
0.3 3.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 2.9 GO:0071439 clathrin complex(GO:0071439)
0.0 2.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 2.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.4 2.4 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 2.4 GO:0000124 SAGA complex(GO:0000124)
0.1 2.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 2.0 GO:0055037 recycling endosome(GO:0055037)
0.0 1.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.8 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.7 GO:0032281 voltage-gated calcium channel complex(GO:0005891) AMPA glutamate receptor complex(GO:0032281)
0.0 1.6 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.3 10.1 GO:0050693 LBD domain binding(GO:0050693)
0.1 8.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 7.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 7.2 GO:0002039 p53 binding(GO:0002039)
0.3 7.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
2.3 6.8 GO:0001851 complement component C3b binding(GO:0001851)
0.1 6.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 6.3 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.5 4.8 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 4.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 3.7 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 3.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.7 3.5 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 3.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.3 3.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 3.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 3.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 2.5 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)