Motif ID: Clock

Z-value: 0.919


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_763045480.332.6e-01Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_121495678 3.509 ENSMUST00000035120.4
 Cck
cholecystokinin
chr6_+_17463927 3.211 ENSMUST00000115442.1
 Met
met proto-oncogene
chr6_+_17463749 3.157 ENSMUST00000115443.1
 Met
met proto-oncogene
chr6_+_17463826 2.727 ENSMUST00000140070.1
 Met
met proto-oncogene
chr2_+_14229390 2.122 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr6_+_108660772 2.049 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr17_-_90455872 1.941 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr6_+_108660616 1.893 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr11_-_100759942 1.680 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr15_-_43170809 1.668 ENSMUST00000063492.6
 Rspo2
R-spondin 2 homolog (Xenopus laevis)
chr11_-_100759740 1.557 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr1_-_186705980 1.422 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr11_-_101785252 1.060 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr5_-_22344690 1.059 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr5_-_76951560 1.050 ENSMUST00000140076.1
 Ppat
phosphoribosyl pyrophosphate amidotransferase
chr1_+_59684949 1.017 ENSMUST00000027174.3
 Nop58
NOP58 ribonucleoprotein
chr6_-_23839137 0.944 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
 Cadps2







Ca2+-dependent activator protein for secretion 2







chr11_-_42182924 0.931 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr4_+_57568144 0.836 ENSMUST00000102904.3
 Palm2
paralemmin 2
chrX_-_51681703 0.760 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 9.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 4.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.4 3.5 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.1 2.0 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.4 1.9 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.8 1.7 GO:0060437 lung growth(GO:0060437)
0.5 1.4 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.2 1.3 GO:0048254 snoRNA localization(GO:0048254)
0.3 1.1 GO:0097107 postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107) lateral motor column neuron migration(GO:0097477)
0.2 1.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 1.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 0.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.9 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 0.8 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.7 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.1 0.7 GO:0006265 DNA topological change(GO:0006265)
0.0 0.6 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 0.5 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.5 GO:0097186 amelogenesis(GO:0097186)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.5 GO:0009925 basal plasma membrane(GO:0009925)
0.3 3.5 GO:0043203 axon hillock(GO:0043203)
0.0 2.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.6 GO:0010008 endosome membrane(GO:0010008)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)
0.0 1.3 GO:0043204 perikaryon(GO:0043204)
0.2 1.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.7 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.3 GO:0032444 activin responsive factor complex(GO:0032444)
0.1 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.3 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.3 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.3 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 9.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.7 3.9 GO:0043426 MRF binding(GO:0043426)
0.0 3.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.2 3.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 2.2 GO:0008201 heparin binding(GO:0008201)
0.1 2.1 GO:0005537 mannose binding(GO:0005537)
0.2 1.9 GO:0097109 neuroligin family protein binding(GO:0097109)
0.4 1.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 1.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 1.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 1.2 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.2 1.1 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.8 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 0.7 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.7 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 0.5 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)