Motif ID: Zic2

Z-value: 0.702


Transcription factors associated with Zic2:

Gene SymbolEntrez IDGene Name
Zic2 ENSMUSG00000061524.8 Zic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic2mm10_v2_chr14_+_122475397_1224754350.371.9e-01Click!


Activity profile for motif Zic2.

activity profile for motif Zic2


Sorted Z-values histogram for motif Zic2

Sorted Z-values for motif Zic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_105373265 0.972 ENSMUST00000160650.1
 Plekhg4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr7_-_19699008 0.600 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr4_+_42240639 0.598 ENSMUST00000117202.2
 Gm10600
predicted gene 10600
chr2_-_25469742 0.585 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr4_+_42091207 0.580 ENSMUST00000178882.1
 Gm3893
predicted gene 3893
chr2_-_25470031 0.566 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr8_-_21906412 0.523 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr11_+_5861886 0.522 ENSMUST00000102923.3
 Aebp1
AE binding protein 1
chr11_+_106160850 0.503 ENSMUST00000100326.1
 Gm10840
predicted gene 10840
chr6_-_35308110 0.503 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr7_-_142666816 0.491 ENSMUST00000105935.1
 Igf2
insulin-like growth factor 2
chr9_+_104002546 0.486 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chr11_+_84525669 0.466 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene

chr14_+_19751257 0.459 ENSMUST00000022340.3
 Nid2
nidogen 2
chr6_+_65671590 0.446 ENSMUST00000054351.4
 Ndnf
neuron-derived neurotrophic factor
chrX_+_170009892 0.416 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chrY_+_90784738 0.387 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1
chr15_+_98708187 0.380 ENSMUST00000003444.4
 Ccdc65
coiled-coil domain containing 65
chr1_+_9908638 0.358 ENSMUST00000171802.1
ENSMUST00000052843.5
ENSMUST00000125294.2
ENSMUST00000140948.2
 Mcmdc2



minichromosome maintenance domain containing 2



chr7_+_127211608 0.354 ENSMUST00000032910.6
 Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.4 1.1 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.2 0.5 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.2 0.5 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.5 GO:0061042 vascular wound healing(GO:0061042)
0.1 0.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.4 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.4 GO:0032060 bleb assembly(GO:0032060)
0.1 0.3 GO:1902037 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.0 0.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.3 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.3 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0010829 negative regulation of glucose transport(GO:0010829)
0.1 0.2 GO:0060126 hypophysis morphogenesis(GO:0048850) somatotropin secreting cell differentiation(GO:0060126)
0.1 0.2 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.2 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 0.2 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0 0.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 1.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 0.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.3 GO:0043205 fibril(GO:0043205)
0.0 0.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.3 GO:0043218 compact myelin(GO:0043218)
0.1 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.2 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.2 GO:0046930 pore complex(GO:0046930)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0097227 sperm annulus(GO:0097227)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.0 GO:0018444 translation release factor complex(GO:0018444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.4 1.1 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.5 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.0 0.2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)