Motif ID: Trp53
Z-value: 0.824
Transcription factors associated with Trp53:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Trp53 | ENSMUSG00000059552.7 | Trp53 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Trp53 | mm10_v2_chr11_+_69580392_69580419 | 0.52 | 5.9e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.6 | GO:0060266 | positive regulation of respiratory burst involved in inflammatory response(GO:0060265) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268) |
0.4 | 1.6 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) |
0.2 | 1.0 | GO:0099624 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) atrial cardiac muscle cell membrane repolarization(GO:0099624) |
0.2 | 1.2 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
0.2 | 0.7 | GO:0002765 | immune response-inhibiting signal transduction(GO:0002765) |
0.2 | 0.6 | GO:0070488 | neutrophil aggregation(GO:0070488) |
0.2 | 2.0 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
0.2 | 0.6 | GO:0046391 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
0.1 | 0.6 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
0.1 | 0.4 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
0.1 | 0.3 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
0.1 | 0.3 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
0.1 | 0.4 | GO:0046294 | formaldehyde catabolic process(GO:0046294) |
0.1 | 0.7 | GO:0042435 | indole-containing compound biosynthetic process(GO:0042435) |
0.1 | 1.2 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.1 | 0.2 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
0.1 | 0.4 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
0.1 | 0.3 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
0.1 | 0.2 | GO:0009182 | purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066) GDP metabolic process(GO:0046710) |
0.1 | 0.3 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
0.0 | 0.1 | GO:1990046 | positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046) |
0.0 | 0.1 | GO:0016561 | protein import into peroxisome matrix, translocation(GO:0016561) |
0.0 | 0.2 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
0.0 | 0.8 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
0.0 | 0.3 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.0 | 0.1 | GO:0046078 | deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078) |
0.0 | 0.3 | GO:0006561 | proline biosynthetic process(GO:0006561) |
0.0 | 0.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.0 | 0.1 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
0.0 | 0.3 | GO:0046415 | urate metabolic process(GO:0046415) |
0.0 | 0.4 | GO:0007096 | regulation of exit from mitosis(GO:0007096) |
0.0 | 0.1 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
0.0 | 0.2 | GO:0061436 | establishment of skin barrier(GO:0061436) |
0.0 | 0.3 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
0.0 | 2.2 | GO:0007052 | mitotic spindle organization(GO:0007052) |
0.0 | 0.3 | GO:0051382 | kinetochore assembly(GO:0051382) |
0.0 | 0.4 | GO:0070986 | left/right axis specification(GO:0070986) |
0.0 | 0.1 | GO:0009812 | flavonoid metabolic process(GO:0009812) flavonoid biosynthetic process(GO:0009813) flavonoid glucuronidation(GO:0052696) |
0.0 | 0.2 | GO:0000103 | sulfate assimilation(GO:0000103) |
0.0 | 0.4 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
0.0 | 0.1 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
0.0 | 0.4 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
0.0 | 0.1 | GO:0070245 | positive regulation of thymocyte apoptotic process(GO:0070245) |
0.0 | 0.2 | GO:0046686 | response to cadmium ion(GO:0046686) |
0.0 | 0.0 | GO:1903903 | regulation of establishment of T cell polarity(GO:1903903) |
0.0 | 0.1 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
0.0 | 0.1 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
0.0 | 0.1 | GO:0006183 | GTP biosynthetic process(GO:0006183) |
0.0 | 0.7 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
0.0 | 0.1 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
0.0 | 0.0 | GO:0070129 | regulation of mitochondrial translation(GO:0070129) |
0.0 | 0.4 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.0 | 0.2 | GO:0035337 | fatty-acyl-CoA metabolic process(GO:0035337) |
0.0 | 0.2 | GO:0048266 | behavioral response to pain(GO:0048266) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.2 | GO:0031262 | Ndc80 complex(GO:0031262) |
0.3 | 1.2 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
0.1 | 1.4 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.1 | 1.7 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.1 | 1.6 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.1 | 0.2 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
0.0 | 1.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.0 | 1.2 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 0.3 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
0.0 | 0.1 | GO:0097227 | sperm annulus(GO:0097227) |
0.0 | 0.2 | GO:0000235 | astral microtubule(GO:0000235) |
0.0 | 0.2 | GO:0042627 | chylomicron(GO:0042627) |
0.0 | 0.6 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.1 | GO:1990130 | Iml1 complex(GO:1990130) |
0.0 | 1.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 0.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.0 | 0.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
0.0 | 0.1 | GO:0045179 | apical cortex(GO:0045179) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.6 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.2 | 0.6 | GO:0032052 | bile acid binding(GO:0032052) |
0.2 | 1.0 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
0.2 | 0.7 | GO:0042015 | interleukin-20 binding(GO:0042015) |
0.1 | 0.4 | GO:0018738 | S-formylglutathione hydrolase activity(GO:0018738) |
0.1 | 1.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.1 | 0.3 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.1 | 0.6 | GO:0050786 | arachidonic acid binding(GO:0050544) RAGE receptor binding(GO:0050786) |
0.1 | 0.3 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
0.1 | 0.4 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
0.1 | 0.2 | GO:0070051 | fibrinogen binding(GO:0070051) |
0.1 | 0.4 | GO:0008494 | translation activator activity(GO:0008494) |
0.1 | 1.2 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
0.0 | 1.6 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.0 | 0.1 | GO:1901611 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
0.0 | 0.3 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.0 | 1.2 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.1 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
0.0 | 1.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 0.7 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
0.0 | 0.1 | GO:0034916 | 4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760) |
0.0 | 0.1 | GO:0043237 | laminin-1 binding(GO:0043237) |
0.0 | 0.2 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
0.0 | 0.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.0 | 0.2 | GO:0016594 | glycine binding(GO:0016594) |
0.0 | 0.3 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
0.0 | 0.3 | GO:0030371 | translation repressor activity(GO:0030371) |
0.0 | 0.1 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.0 | 0.1 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
0.0 | 0.2 | GO:1990939 | ATP-dependent microtubule motor activity(GO:1990939) |