Motif ID: Zfp423

Z-value: 0.522


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87959560_87959595-0.602.5e-02Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Showing 1 to 20 of 69 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_119138415 0.958 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr6_+_110645572 0.940 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr1_+_167598450 0.870 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr11_+_82101836 0.759 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr6_+_86628174 0.714 ENSMUST00000043400.6
 Asprv1
aspartic peptidase, retroviral-like 1
chr19_+_6401675 0.676 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr11_+_102836296 0.658 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr4_-_106464167 0.637 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr7_-_45870928 0.514 ENSMUST00000146672.1
 Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr8_+_27260327 0.505 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr1_+_167598384 0.502 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr9_+_120492606 0.500 ENSMUST00000007139.4
 Eif1b
eukaryotic translation initiation factor 1B
chrX_+_101254528 0.486 ENSMUST00000062000.4
 Foxo4
forkhead box O4
chr14_-_70520254 0.472 ENSMUST00000022693.7
 Bmp1
bone morphogenetic protein 1
chr9_-_37552904 0.438 ENSMUST00000065668.5
 Nrgn
neurogranin
chrX_+_58030999 0.429 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr11_-_33203588 0.408 ENSMUST00000037746.6
 Tlx3
T cell leukemia, homeobox 3
chr2_-_29253001 0.380 ENSMUST00000071201.4
 Ntng2
netrin G2
chr6_+_6863769 0.351 ENSMUST00000031768.6
 Dlx6
distal-less homeobox 6
chr3_-_85887472 0.350 ENSMUST00000033643.5
ENSMUST00000154148.1
 Glt28d2
Arfip1
glycosyltransferase 28 domain containing 2
ADP-ribosylation factor interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2 1.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 0.9 GO:0001661 conditioned taste aversion(GO:0001661)
0.3 0.8 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.1 0.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 0.6 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 0.5 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 0.5 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.5 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.5 GO:0061036 positive regulation of cartilage development(GO:0061036)
0.0 0.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 0.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 0.3 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)

Gene overrepresentation in cellular_component category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 0.6 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 1.0 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.3 0.9 GO:0070905 serine binding(GO:0070905)
0.2 0.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.2 0.6 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.0 0.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.2 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.0 GO:0050827 toxin receptor binding(GO:0050827)