Motif ID: Zfp423

Z-value: 0.522


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87959560_87959595-0.602.5e-02Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_119138415 0.958 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr6_+_110645572 0.940 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr1_+_167598450 0.870 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr11_+_82101836 0.759 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr6_+_86628174 0.714 ENSMUST00000043400.6
 Asprv1
aspartic peptidase, retroviral-like 1
chr19_+_6401675 0.676 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr11_+_102836296 0.658 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr4_-_106464167 0.637 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr7_-_45870928 0.514 ENSMUST00000146672.1
 Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr8_+_27260327 0.505 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr1_+_167598384 0.502 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr9_+_120492606 0.500 ENSMUST00000007139.4
 Eif1b
eukaryotic translation initiation factor 1B
chrX_+_101254528 0.486 ENSMUST00000062000.4
 Foxo4
forkhead box O4
chr14_-_70520254 0.472 ENSMUST00000022693.7
 Bmp1
bone morphogenetic protein 1
chr9_-_37552904 0.438 ENSMUST00000065668.5
 Nrgn
neurogranin
chrX_+_58030999 0.429 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr11_-_33203588 0.408 ENSMUST00000037746.6
 Tlx3
T cell leukemia, homeobox 3
chr2_-_29253001 0.380 ENSMUST00000071201.4
 Ntng2
netrin G2
chr6_+_6863769 0.351 ENSMUST00000031768.6
 Dlx6
distal-less homeobox 6
chr3_-_85887472 0.350 ENSMUST00000033643.5
ENSMUST00000154148.1
 Glt28d2
Arfip1
glycosyltransferase 28 domain containing 2
ADP-ribosylation factor interacting protein 1
chrX_+_58030622 0.323 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr17_-_10840285 0.312 ENSMUST00000041463.6
 Pacrg
PARK2 co-regulated
chr13_-_47106176 0.303 ENSMUST00000021807.6
ENSMUST00000135278.1
 Dek

DEK oncogene (DNA binding)

chr16_+_17489639 0.291 ENSMUST00000023448.6
 Aifm3
apoptosis-inducing factor, mitochondrion-associated 3
chr7_-_70360593 0.271 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr4_+_129513581 0.233 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr4_+_154237525 0.223 ENSMUST00000152159.1
 Megf6
multiple EGF-like-domains 6
chr17_+_86963077 0.211 ENSMUST00000024956.8
 Rhoq
ras homolog gene family, member Q
chr11_-_106160101 0.199 ENSMUST00000045923.3
 Limd2
LIM domain containing 2
chr8_-_83699095 0.180 ENSMUST00000005616.8
 Pkn1
protein kinase N1
chr8_-_41016749 0.175 ENSMUST00000117735.1
 Mtus1
mitochondrial tumor suppressor 1
chr19_-_10101501 0.167 ENSMUST00000025567.7
 Fads2
fatty acid desaturase 2
chr7_-_34196608 0.150 ENSMUST00000148381.1
ENSMUST00000002710.3
 Pdcd2l

programmed cell death 2-like

chr17_-_35074485 0.147 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr7_+_45705518 0.146 ENSMUST00000107740.1
ENSMUST00000107741.1
 Dbp

D site albumin promoter binding protein

chr4_+_31964081 0.142 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
 Map3k7



mitogen-activated protein kinase kinase kinase 7



chr9_+_57130690 0.138 ENSMUST00000160147.1
ENSMUST00000161663.1
ENSMUST00000034836.9
ENSMUST00000161182.1
 Man2c1



mannosidase, alpha, class 2C, member 1



chr4_+_129820198 0.131 ENSMUST00000030578.7
 Ptp4a2
protein tyrosine phosphatase 4a2
chr7_-_105633525 0.123 ENSMUST00000153371.1
ENSMUST00000106789.1
ENSMUST00000057525.7
 Trim3


tripartite motif-containing 3


chr2_+_164785823 0.114 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
 Snx21


sorting nexin family member 21


chr17_-_32166879 0.114 ENSMUST00000087723.3
 Notch3
notch 3
chr11_+_54902917 0.112 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr11_-_115536181 0.110 ENSMUST00000118155.1
ENSMUST00000153892.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr5_-_136565432 0.108 ENSMUST00000176172.1
 Cux1
cut-like homeobox 1
chr7_-_25754701 0.107 ENSMUST00000108401.1
ENSMUST00000043765.7
 Hnrnpul1

heterogeneous nuclear ribonucleoprotein U-like 1

chr17_-_29347902 0.105 ENSMUST00000095427.4
ENSMUST00000118366.1
 Mtch1

mitochondrial carrier homolog 1 (C. elegans)

chr1_-_51941261 0.104 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr2_+_164785994 0.103 ENSMUST00000152471.1
 Snx21
sorting nexin family member 21
chr19_-_10869757 0.102 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr2_-_30359278 0.100 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
 Sh3glb2


SH3-domain GRB2-like endophilin B2


chr7_-_105633479 0.093 ENSMUST00000147044.1
ENSMUST00000106791.1
 Trim3

tripartite motif-containing 3

chr7_-_16286744 0.089 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
 Ccdc9


coiled-coil domain containing 9


chr2_-_30359190 0.089 ENSMUST00000100215.4
ENSMUST00000113620.3
 Sh3glb2

SH3-domain GRB2-like endophilin B2

chr11_-_115535804 0.083 ENSMUST00000117589.1
ENSMUST00000121185.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chrX_-_75130844 0.072 ENSMUST00000114092.1
ENSMUST00000132501.1
ENSMUST00000153318.1
ENSMUST00000155742.1
 Mpp1



membrane protein, palmitoylated



chr12_+_69184158 0.071 ENSMUST00000060579.8
 Mgat2
mannoside acetylglucosaminyltransferase 2
chr7_+_127485221 0.067 ENSMUST00000048896.6
 Fbrs
fibrosin
chr12_-_14152038 0.066 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chrX_-_75130914 0.061 ENSMUST00000114091.1
 Mpp1
membrane protein, palmitoylated
chr2_-_147085445 0.058 ENSMUST00000067020.2
 Nkx2-4
NK2 homeobox 4
chr12_-_69183986 0.045 ENSMUST00000110620.1
ENSMUST00000110619.1
 Rpl36al

ribosomal protein L36A-like

chr6_-_124756478 0.041 ENSMUST00000088357.5
 Atn1
atrophin 1
chr12_+_109459843 0.036 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr10_+_81136223 0.029 ENSMUST00000048128.8
 Zbtb7a
zinc finger and BTB domain containing 7a
chrX_+_7822289 0.029 ENSMUST00000009875.4
 Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr10_+_3973086 0.025 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr2_+_180499893 0.010 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr8_-_94012558 0.002 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr12_-_69184056 0.002 ENSMUST00000054544.6
 Rpl36al
ribosomal protein L36A-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.2 0.6 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.2 0.9 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 1.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.5 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 0.5 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 0.3 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 1.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.5 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.1 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.5 GO:0061036 positive regulation of cartilage development(GO:0061036)
0.0 0.6 GO:0071277 cellular response to calcium ion(GO:0071277)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.2 0.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0070905 serine binding(GO:0070905)
0.2 0.6 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.2 0.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 1.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0 0.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.0 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 0.4 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.0 GO:0050827 toxin receptor binding(GO:0050827)
0.0 0.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)