Motif ID: Gbx2

Z-value: 0.633


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_899332900.263.8e-01Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_59170978 1.923 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr14_-_48667508 1.898 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr8_-_21906412 1.283 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr3_-_116129615 0.884 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr13_-_97747373 0.694 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 0.664 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr18_+_56432116 0.663 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chrM_-_14060 0.660 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr5_-_111761697 0.645 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr11_-_79504078 0.600 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr13_+_49544443 0.576 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr3_-_113577743 0.548 ENSMUST00000067980.5
 Amy1
amylase 1, salivary
chr13_+_31806627 0.545 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr16_-_36784924 0.496 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
 Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr2_+_152754156 0.467 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr16_-_36784784 0.459 ENSMUST00000165531.1
 Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr17_-_36032682 0.454 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr12_+_111814170 0.449 ENSMUST00000021714.7
 Zfyve21
zinc finger, FYVE domain containing 21
chr13_+_23763660 0.439 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chr11_+_59306920 0.437 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr12_+_79297345 0.418 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr7_-_30664986 0.398 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr11_-_5878207 0.379 ENSMUST00000102922.3
 Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr14_+_69347587 0.370 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr16_-_22439719 0.309 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr14_-_18893376 0.288 ENSMUST00000151926.1
 Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr4_+_118961578 0.287 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr14_+_58893465 0.287 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr5_-_31295862 0.267 ENSMUST00000041266.7
ENSMUST00000172435.1
 Fndc4

fibronectin type III domain containing 4

chr1_-_128102412 0.267 ENSMUST00000112538.1
ENSMUST00000086614.5
 Zranb3

zinc finger, RAN-binding domain containing 3

chr3_-_89998656 0.251 ENSMUST00000079724.4
 Hax1
HCLS1 associated X-1
chr5_+_115341225 0.248 ENSMUST00000031508.4
 Triap1
TP53 regulated inhibitor of apoptosis 1
chr2_-_157566319 0.244 ENSMUST00000109528.2
ENSMUST00000088494.2
 Blcap

bladder cancer associated protein homolog (human)

chr7_+_78783119 0.219 ENSMUST00000032840.4
 Mrps11
mitochondrial ribosomal protein S11
chr2_-_160619971 0.218 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr11_-_45955183 0.210 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr4_+_110397661 0.181 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr7_+_28810886 0.180 ENSMUST00000038572.8
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr3_+_94372794 0.176 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr10_-_95501921 0.150 ENSMUST00000075829.2
 Mrpl42
mitochondrial ribosomal protein L42
chr1_-_24005608 0.148 ENSMUST00000027338.3
 1110058L19Rik
RIKEN cDNA 1110058L19 gene
chr1_-_175625580 0.136 ENSMUST00000027810.7
 Fh1
fumarate hydratase 1
chr4_-_129261394 0.123 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr11_-_103267405 0.090 ENSMUST00000021324.2
 Map3k14
mitogen-activated protein kinase kinase kinase 14
chr9_+_96258697 0.084 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr15_+_103240405 0.073 ENSMUST00000036004.9
ENSMUST00000087351.7
 Hnrnpa1

heterogeneous nuclear ribonucleoprotein A1

chr16_+_44394771 0.068 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr5_+_113735782 0.066 ENSMUST00000065698.5
 Ficd
FIC domain containing
chr10_+_128083273 0.029 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr7_-_78783026 0.013 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 1.9 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.2 1.0 GO:0042938 dipeptide transport(GO:0042938)
0.2 0.5 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.2 0.5 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.4 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.1 0.6 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.3 GO:0036292 DNA rewinding(GO:0036292)
0.1 0.9 GO:0061032 chorio-allantoic fusion(GO:0060710) visceral serous pericardium development(GO:0061032)
0.1 0.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 0.6 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.2 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0 0.2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.4 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.2 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.0 GO:0042895 antibiotic transporter activity(GO:0042895)
0.2 0.5 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.3 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.3 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.4 GO:0000150 recombinase activity(GO:0000150)
0.1 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.4 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.2 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.0 0.3 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.2 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)