Motif ID: Ptf1a

Z-value: 0.718


Transcription factors associated with Ptf1a:

Gene SymbolEntrez IDGene Name
Ptf1a ENSMUSG00000026735.2 Ptf1a



Activity profile for motif Ptf1a.

activity profile for motif Ptf1a


Sorted Z-values histogram for motif Ptf1a

Sorted Z-values for motif Ptf1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Ptf1a

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_91269759 4.165 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr14_-_70207637 2.665 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr4_-_64046925 1.783 ENSMUST00000107377.3
 Tnc
tenascin C
chr19_+_7056731 1.575 ENSMUST00000040261.5
 Macrod1
MACRO domain containing 1
chr11_+_78324200 1.399 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr2_+_31470207 1.349 ENSMUST00000102840.4
 Ass1
argininosuccinate synthetase 1
chr12_+_112760652 1.232 ENSMUST00000063888.3
 Pld4
phospholipase D family, member 4
chr10_-_75932468 1.216 ENSMUST00000120281.1
ENSMUST00000000924.6
 Mmp11

matrix metallopeptidase 11

chr9_-_21852603 0.834 ENSMUST00000034728.7
 Dock6
dedicator of cytokinesis 6
chr9_-_112187898 0.727 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr17_-_27513341 0.669 ENSMUST00000118161.1
 Grm4
glutamate receptor, metabotropic 4
chr11_-_109611417 0.658 ENSMUST00000103060.3
ENSMUST00000047186.3
ENSMUST00000106689.1
 Wipi1


WD repeat domain, phosphoinositide interacting 1


chr10_+_60346851 0.629 ENSMUST00000020301.7
ENSMUST00000105460.1
ENSMUST00000170507.1
 4632428N05Rik


RIKEN cDNA 4632428N05 gene


chr2_+_164769892 0.595 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr10_-_77089428 0.578 ENSMUST00000156009.1
 Col18a1
collagen, type XVIII, alpha 1
chr7_-_99182681 0.566 ENSMUST00000033001.4
 Dgat2
diacylglycerol O-acyltransferase 2
chr9_-_108305941 0.550 ENSMUST00000044725.7
 Tcta
T cell leukemia translocation altered gene
chr9_-_108597558 0.536 ENSMUST00000006853.5
 P4htm
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr4_-_88438900 0.526 ENSMUST00000132493.1
ENSMUST00000030221.2
ENSMUST00000151280.1
 Ptplad2


protein tyrosine phosphatase-like A domain containing 2


chr16_-_55283237 0.500 ENSMUST00000036412.3
 Zpld1
zona pellucida like domain containing 1
chr11_-_103344651 0.472 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr11_-_6444352 0.465 ENSMUST00000093346.5
ENSMUST00000109737.2
 H2afv

H2A histone family, member V

chr11_+_49247462 0.443 ENSMUST00000109194.1
 Mgat1
mannoside acetylglucosaminyltransferase 1
chr5_-_99252839 0.439 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr3_+_138277489 0.412 ENSMUST00000004232.9
 Adh1
alcohol dehydrogenase 1 (class I)
chr9_+_123021315 0.407 ENSMUST00000084733.5
 Tmem42
transmembrane protein 42
chr5_+_149439706 0.401 ENSMUST00000031667.4
 Tex26
testis expressed 26
chr14_+_53324632 0.388 ENSMUST00000178100.1
 Trav7n-6
T cell receptor alpha variable 7N-6
chr7_-_4532419 0.380 ENSMUST00000094897.4
 Dnaaf3
dynein, axonemal assembly factor 3
chr4_+_155839675 0.378 ENSMUST00000141883.1
 Mxra8
matrix-remodelling associated 8
chr1_+_92910805 0.376 ENSMUST00000179711.1
 Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr14_-_55944536 0.364 ENSMUST00000022834.6
 Cma1
chymase 1, mast cell
chr15_-_98004634 0.355 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr2_-_30415302 0.353 ENSMUST00000132981.2
ENSMUST00000129494.1
 Crat

carnitine acetyltransferase

chr7_-_79842287 0.347 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase
chr2_+_164948219 0.344 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr2_+_26973416 0.327 ENSMUST00000014996.7
ENSMUST00000102891.3
 Adamts13

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

chr4_-_155010984 0.317 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr6_+_83078606 0.314 ENSMUST00000177177.1
ENSMUST00000176089.1
 Pcgf1

polycomb group ring finger 1

chr6_+_83078339 0.314 ENSMUST00000165164.2
ENSMUST00000092614.2
 Pcgf1

polycomb group ring finger 1

chr17_+_7925990 0.311 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr6_-_5256226 0.299 ENSMUST00000125686.1
ENSMUST00000031773.2
 Pon3

paraoxonase 3

chr5_-_31048014 0.290 ENSMUST00000137223.1
 Slc5a6
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
chr2_-_131175201 0.290 ENSMUST00000110218.2
 Spef1
sperm flagellar 1
chr11_+_120633719 0.259 ENSMUST00000181502.1
 Gm17586
predicted gene, 17586
chr1_+_92910758 0.219 ENSMUST00000027487.8
 Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr8_-_105295934 0.217 ENSMUST00000057855.3
 Exoc3l
exocyst complex component 3-like
chr11_+_82911253 0.215 ENSMUST00000164945.1
ENSMUST00000018989.7
 Unc45b

unc-45 homolog B (C. elegans)

chr14_+_75845093 0.213 ENSMUST00000110894.2
 Tpt1
tumor protein, translationally-controlled 1
chr11_+_78465697 0.213 ENSMUST00000001126.3
 Slc46a1
solute carrier family 46, member 1
chr7_-_79386943 0.211 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr9_-_112187766 0.206 ENSMUST00000111872.2
ENSMUST00000164754.2
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr11_-_100441006 0.204 ENSMUST00000092689.2
 Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr15_-_98004695 0.193 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr10_+_127501672 0.187 ENSMUST00000160019.1
ENSMUST00000160610.1
 Stac3

SH3 and cysteine rich domain 3

chr2_-_91950386 0.177 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chr11_-_100440928 0.175 ENSMUST00000107397.1
 Nt5c3b
5'-nucleotidase, cytosolic IIIB
chrX_+_101383726 0.168 ENSMUST00000119190.1
 Gjb1
gap junction protein, beta 1
chr5_+_114314941 0.166 ENSMUST00000124316.1
ENSMUST00000169347.1
 Myo1h

myosin 1H

chr3_-_75556759 0.165 ENSMUST00000162138.1
ENSMUST00000029424.5
ENSMUST00000161137.1
 Pdcd10


programmed cell death 10


chr7_-_127725616 0.164 ENSMUST00000076091.2
 Ctf2
cardiotrophin 2
chr2_-_175131864 0.163 ENSMUST00000108929.2
 Gm14399
predicted gene 14399
chr11_-_100441058 0.160 ENSMUST00000107399.2
ENSMUST00000092688.5
 Nt5c3b

5'-nucleotidase, cytosolic IIIB

chr10_+_86022189 0.145 ENSMUST00000120344.1
ENSMUST00000117597.1
 Fbxo7

F-box protein 7

chrX_-_164076482 0.143 ENSMUST00000134272.1
 Siah1b
seven in absentia 1B
chr15_-_99087817 0.142 ENSMUST00000064462.3
 C1ql4
complement component 1, q subcomponent-like 4
chr15_-_79774383 0.136 ENSMUST00000069877.5
 Dnal4
dynein, axonemal, light chain 4
chr5_+_64970069 0.132 ENSMUST00000031080.8
 Fam114a1
family with sequence similarity 114, member A1
chr2_+_25500750 0.130 ENSMUST00000015239.3
 Fbxw5
F-box and WD-40 domain protein 5
chrX_+_166238923 0.130 ENSMUST00000060210.7
ENSMUST00000112233.1
 Gpm6b

glycoprotein m6b

chr15_-_79774408 0.122 ENSMUST00000023055.6
 Dnal4
dynein, axonemal, light chain 4
chr1_+_36691487 0.120 ENSMUST00000081180.4
 Cox5b
cytochrome c oxidase subunit Vb
chr11_-_96916448 0.109 ENSMUST00000103152.4
 Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr16_+_43762221 0.107 ENSMUST00000023390.4
 Drd3
dopamine receptor D3
chr4_-_133887765 0.102 ENSMUST00000003741.9
ENSMUST00000105894.4
 Rps6ka1

ribosomal protein S6 kinase polypeptide 1

chr9_-_44735189 0.099 ENSMUST00000034611.8
 Phldb1
pleckstrin homology-like domain, family B, member 1
chr4_+_115088708 0.097 ENSMUST00000171877.1
ENSMUST00000177647.1
ENSMUST00000106548.2
ENSMUST00000030488.2
 Pdzk1ip1



PDZK1 interacting protein 1



chr10_+_127501707 0.087 ENSMUST00000035839.2
 Stac3
SH3 and cysteine rich domain 3
chr7_-_25718976 0.085 ENSMUST00000002683.2
 Ccdc97
coiled-coil domain containing 97
chr8_+_94857450 0.077 ENSMUST00000109521.3
 Polr2c
polymerase (RNA) II (DNA directed) polypeptide C
chr9_+_106477269 0.063 ENSMUST00000047721.8
 Rrp9
RRP9, small subunit (SSU) processome component, homolog (yeast)
chr4_+_152096719 0.045 ENSMUST00000105661.3
ENSMUST00000084115.3
 Plekhg5

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

chr19_-_7241216 0.044 ENSMUST00000025675.9
 Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr4_-_12087912 0.040 ENSMUST00000050686.3
 Tmem67
transmembrane protein 67
chr19_+_16435616 0.037 ENSMUST00000025602.2
 Gna14
guanine nucleotide binding protein, alpha 14
chr19_+_9982694 0.033 ENSMUST00000025563.6
 Fth1
ferritin heavy chain 1
chr3_-_108445183 0.033 ENSMUST00000090553.5
ENSMUST00000153499.1
 Sars

seryl-aminoacyl-tRNA synthetase

chr11_+_48800357 0.031 ENSMUST00000020640.7
 Gnb2l1
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
chr1_-_88008520 0.022 ENSMUST00000040783.4
 Usp40
ubiquitin specific peptidase 40
chr1_+_36471590 0.012 ENSMUST00000153128.1
 Cnnm4
cyclin M4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.4 1.6 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.3 1.3 GO:0010046 arginine biosynthetic process(GO:0006526) response to mycotoxin(GO:0010046)
0.1 1.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.4 GO:0034310 primary alcohol catabolic process(GO:0034310)
0.1 0.6 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.4 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 1.6 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.6 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.1 0.3 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.1 0.7 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.1 0.2 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.1 0.1 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.1 0.2 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1 0.2 GO:0015886 heme transport(GO:0015886)
0.1 0.4 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 2.7 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.5 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 1.3 GO:0043171 peptide catabolic process(GO:0043171)
0.0 4.2 GO:0048663 neuron fate commitment(GO:0048663)
0.0 0.6 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.4 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.6 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.3 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.5 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.0 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.3 GO:0070852 cell body fiber(GO:0070852)
0.0 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0045298 tubulin complex(GO:0045298)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0045545 syndecan binding(GO:0045545)
0.2 1.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 0.6 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.2 2.7 GO:0017166 vinculin binding(GO:0017166)
0.2 1.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 1.3 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 1.6 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.1 0.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.4 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 0.3 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.2 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.3 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588) dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0019841 retinol binding(GO:0019841)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 0.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)