Motif ID: Sox2

Z-value: 2.620


Transcription factors associated with Sox2:

Gene SymbolEntrez IDGene Name
Sox2 ENSMUSG00000074637.4 Sox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox2mm10_v2_chr3_+_34649987_34650005-0.516.2e-02Click!


Activity profile for motif Sox2.

activity profile for motif Sox2


Sorted Z-values histogram for motif Sox2

Sorted Z-values for motif Sox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_31713873 8.201 ENSMUST00000057783.4
ENSMUST00000174480.2
ENSMUST00000176710.1
 Gpr22


G protein-coupled receptor 22


chr4_+_102254739 6.436 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_62965560 5.947 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr4_+_125490688 5.732 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr6_+_51432663 5.385 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr10_-_122047293 5.168 ENSMUST00000020322.5
ENSMUST00000081688.6
 Srgap1

SLIT-ROBO Rho GTPase activating protein 1

chr6_+_51432678 4.936 ENSMUST00000160133.1
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr3_+_103576081 4.777 ENSMUST00000183637.1
ENSMUST00000117221.2
ENSMUST00000118117.1
ENSMUST00000118563.2
 Syt6



synaptotagmin VI



chr6_-_144209558 4.670 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209471 4.616 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209448 4.574 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr2_-_57124003 4.492 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr14_+_61138445 4.431 ENSMUST00000089394.3
ENSMUST00000119509.1
 Sacs

sacsin

chrX_-_143933089 4.405 ENSMUST00000087313.3
 Dcx
doublecortin
chr9_+_118478344 4.286 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr18_-_43059418 4.220 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr10_+_80150448 3.940 ENSMUST00000153477.1
 Midn
midnolin
chr5_+_75574916 3.912 ENSMUST00000144270.1
ENSMUST00000005815.6
 Kit

kit oncogene

chr9_+_118478851 3.809 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr7_-_120982260 3.797 ENSMUST00000033169.8
 Cdr2
cerebellar degeneration-related 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 397 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 13.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
1.0 12.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.6 9.5 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
2.1 8.2 GO:0051866 general adaptation syndrome(GO:0051866)
2.7 8.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 7.4 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
1.0 6.8 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 6.8 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.4 6.7 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715)
0.4 6.6 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 6.4 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 6.3 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.5 6.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 5.6 GO:0035329 hippo signaling(GO:0035329)
0.1 5.0 GO:0021954 central nervous system neuron development(GO:0021954)
0.6 4.9 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
1.6 4.8 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 4.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
1.4 4.2 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.6 4.2 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.8 GO:0043198 dendritic shaft(GO:0043198)
0.6 12.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.4 10.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 7.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.3 7.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 7.4 GO:0005925 focal adhesion(GO:0005925)
0.3 6.7 GO:0071565 nBAF complex(GO:0071565)
1.3 6.6 GO:0008623 CHRAC(GO:0008623)
0.7 6.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 5.3 GO:0005871 kinesin complex(GO:0005871)
0.0 5.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 5.0 GO:0030673 axolemma(GO:0030673)
0.0 4.9 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 4.6 GO:0016607 nuclear speck(GO:0016607)
0.2 4.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 4.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 4.1 GO:0000145 exocyst(GO:0000145)
0.4 3.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 3.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.6 3.7 GO:1990635 proximal dendrite(GO:1990635)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 264 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.2 GO:0008270 zinc ion binding(GO:0008270)
0.4 16.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 10.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 9.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 8.5 GO:0042277 peptide binding(GO:0042277)
1.0 7.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 7.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 7.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.4 6.8 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.3 6.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.3 6.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 6.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 6.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 6.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.7 5.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.6 5.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 5.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 5.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.4 4.7 GO:0030957 Tat protein binding(GO:0030957)
0.0 4.7 GO:0003735 structural constituent of ribosome(GO:0003735)