Motif ID: Tfap2c

Z-value: 1.425


Transcription factors associated with Tfap2c:

Gene SymbolEntrez IDGene Name
Tfap2c ENSMUSG00000028640.5 Tfap2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2cmm10_v2_chr2_+_172550761_172550782-0.488.5e-02Click!


Activity profile for motif Tfap2c.

activity profile for motif Tfap2c


Sorted Z-values histogram for motif Tfap2c

Sorted Z-values for motif Tfap2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91225550 4.615 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr15_+_76457438 4.177 ENSMUST00000043089.7
 Scx
scleraxis
chr8_+_70493156 4.095 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr5_-_71095765 3.785 ENSMUST00000000572.5
 Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr4_-_22488296 3.341 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr19_-_28680077 3.126 ENSMUST00000162022.1
ENSMUST00000112612.2
 Glis3

GLIS family zinc finger 3

chr5_-_35679416 3.074 ENSMUST00000114233.2
 Htra3
HtrA serine peptidase 3
chr13_-_23622502 2.896 ENSMUST00000062045.2
 Hist1h1e
histone cluster 1, H1e
chr1_-_75264195 2.857 ENSMUST00000027404.5
 Ptprn
protein tyrosine phosphatase, receptor type, N
chrX_-_101085352 2.729 ENSMUST00000101362.1
ENSMUST00000073927.4
 Slc7a3

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

chr12_-_76709997 2.727 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr6_+_140424086 2.587 ENSMUST00000087622.3
 Plekha5
pleckstrin homology domain containing, family A member 5
chr2_+_152736244 2.469 ENSMUST00000038368.8
ENSMUST00000109824.1
 Id1

inhibitor of DNA binding 1

chr12_+_103314944 2.353 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr11_-_116110211 2.160 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr4_+_129136948 2.122 ENSMUST00000102600.3
 Fndc5
fibronectin type III domain containing 5
chr5_+_144545883 2.085 ENSMUST00000071782.6
 Nptx2
neuronal pentraxin 2
chr14_+_119138415 2.050 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr6_-_12749193 2.016 ENSMUST00000046121.6
ENSMUST00000172356.1
 Thsd7a

thrombospondin, type I, domain containing 7A

chr19_+_59458372 2.012 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
1.0 4.2 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.7 4.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.6 4.0 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 3.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.7 3.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.3 3.3 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 3.1 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.2 3.0 GO:0043589 skin morphogenesis(GO:0043589)
0.4 2.9 GO:0016584 nucleosome positioning(GO:0016584)
0.2 2.9 GO:0001553 luteinization(GO:0001553)
0.1 2.9 GO:0048535 lymph node development(GO:0048535)
0.5 2.7 GO:0015819 lysine transport(GO:0015819)
0.1 2.7 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.5 2.5 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.4 2.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.8 2.4 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.6 2.4 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.5 2.0 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.3 2.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.7 GO:0005667 transcription factor complex(GO:0005667)
1.4 4.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 3.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 3.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.1 3.4 GO:0005584 collagen type I trimer(GO:0005584)
0.1 3.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.9 GO:0000786 nucleosome(GO:0000786)
0.5 2.7 GO:0008091 spectrin(GO:0008091)
0.1 2.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 2.4 GO:0005638 lamin filament(GO:0005638)
0.0 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.4 1.8 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.8 GO:0097542 ciliary tip(GO:0097542)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.6 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0 1.5 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.3 1.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.3 1.0 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 6.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.4 GO:0070888 E-box binding(GO:0070888)
0.1 4.5 GO:0035064 methylated histone binding(GO:0035064)
0.6 4.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.2 3.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 3.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 3.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 3.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 3.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.9 GO:0030507 spectrin binding(GO:0030507)
0.4 2.7 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.1 2.7 GO:0030506 ankyrin binding(GO:0030506)
0.2 2.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 2.5 GO:0070628 proteasome binding(GO:0070628)
0.3 2.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 2.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.4 GO:0005125 cytokine activity(GO:0005125)
0.0 2.3 GO:0005179 hormone activity(GO:0005179)
0.0 2.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)