Motif ID: Bhlhe40

Z-value: 0.868


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660616_108660682-0.421.3e-01Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_110095937 3.163 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
 Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr7_+_121707189 2.241 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr11_-_110095974 1.947 ENSMUST00000100287.2
 Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr16_+_8830093 1.736 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr5_+_65199691 1.640 ENSMUST00000041892.8
 Wdr19
WD repeat domain 19
chr5_+_123252087 1.497 ENSMUST00000121964.1
 Wdr66
WD repeat domain 66
chr7_+_35802593 1.381 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr7_-_35802968 1.258 ENSMUST00000061586.4
 Zfp507
zinc finger protein 507
chr2_+_166805506 1.147 ENSMUST00000099078.3
 Arfgef2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr12_+_86947343 1.082 ENSMUST00000038369.4
 2310044G17Rik
RIKEN cDNA 2310044G17 gene
chr4_-_137048695 1.076 ENSMUST00000049583.7
 Zbtb40
zinc finger and BTB domain containing 40
chr5_-_123572976 1.054 ENSMUST00000031388.8
 Vps33a
vacuolar protein sorting 33A (yeast)
chr11_+_55204319 1.029 ENSMUST00000108872.2
ENSMUST00000147506.1
ENSMUST00000020499.7
 Slc36a1


solute carrier family 36 (proton/amino acid symporter), member 1


chr2_-_30286312 1.026 ENSMUST00000100219.3
 Dolk
dolichol kinase
chr7_-_90475971 0.972 ENSMUST00000032843.7
 Tmem126b
transmembrane protein 126B
chr4_+_148039035 0.967 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr12_-_3426700 0.966 ENSMUST00000180149.1
 1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr16_-_44139003 0.932 ENSMUST00000124102.1
 Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr17_+_70561739 0.899 ENSMUST00000097288.2
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_-_12769605 0.898 ENSMUST00000024599.7
 Igf2r
insulin-like growth factor 2 receptor
chr4_-_141790891 0.880 ENSMUST00000038014.4
ENSMUST00000153880.1
 Dnajc16

DnaJ (Hsp40) homolog, subfamily C, member 16

chr7_+_128744870 0.869 ENSMUST00000042942.8
 Sec23ip
Sec23 interacting protein
chr4_-_48473403 0.846 ENSMUST00000164866.1
ENSMUST00000030030.8
 Tex10

testis expressed gene 10

chr8_+_85037151 0.781 ENSMUST00000166592.1
 Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr4_+_148039097 0.778 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr8_-_84846860 0.771 ENSMUST00000003912.6
 Calr
calreticulin
chr8_+_85036906 0.731 ENSMUST00000093360.4
 Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr12_-_84450944 0.700 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr6_+_72097561 0.689 ENSMUST00000069994.4
ENSMUST00000114112.1
 St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr2_+_30286406 0.664 ENSMUST00000138666.1
ENSMUST00000113634.2
 Nup188

nucleoporin 188

chrX_-_152327430 0.655 ENSMUST00000181635.1
ENSMUST00000141922.1
ENSMUST00000154085.1
ENSMUST00000148326.1
ENSMUST00000135115.1
ENSMUST00000149098.1
 2900056M20Rik





RIKEN cDNA 2900056M20 gene





chr11_+_97450136 0.630 ENSMUST00000107601.1
 Arhgap23
Rho GTPase activating protein 23
chr2_-_37703845 0.610 ENSMUST00000155237.1
 Strbp
spermatid perinuclear RNA binding protein
chr18_-_20896078 0.605 ENSMUST00000025177.6
ENSMUST00000097658.1
 Trappc8

trafficking protein particle complex 8

chr3_-_107333289 0.590 ENSMUST00000061772.9
 Rbm15
RNA binding motif protein 15
chr2_+_30286383 0.584 ENSMUST00000064447.5
 Nup188
nucleoporin 188
chr11_-_75348261 0.584 ENSMUST00000000767.5
ENSMUST00000092907.5
 Rpa1

replication protein A1

chr3_+_96727611 0.575 ENSMUST00000029740.9
 Rnf115
ring finger protein 115
chr16_-_44139630 0.565 ENSMUST00000137557.1
ENSMUST00000147025.1
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr3_-_10440054 0.505 ENSMUST00000099223.4
ENSMUST00000029047.6
 Snx16

sorting nexin 16

chr11_+_75348433 0.492 ENSMUST00000044530.2
 Smyd4
SET and MYND domain containing 4
chr11_-_75454656 0.469 ENSMUST00000173320.1
 Wdr81
WD repeat domain 81
chrX_-_136203637 0.427 ENSMUST00000151592.1
ENSMUST00000131510.1
ENSMUST00000066819.4
 Tceal5


transcription elongation factor A (SII)-like 5


chr18_+_31609512 0.383 ENSMUST00000164667.1
 B930094E09Rik
RIKEN cDNA B930094E09 gene
chr7_+_82648595 0.350 ENSMUST00000141726.1
ENSMUST00000179489.1
ENSMUST00000039881.3
 Eftud1


elongation factor Tu GTP binding domain containing 1


chr10_-_18023229 0.347 ENSMUST00000020002.7
 Abracl
ABRA C-terminal like
chr16_+_5050012 0.341 ENSMUST00000052449.5
 Ubn1
ubinuclein 1
chr6_-_35133731 0.328 ENSMUST00000114993.2
ENSMUST00000114989.2
ENSMUST00000044163.6
 Cnot4


CCR4-NOT transcription complex, subunit 4


chrX_+_134601271 0.324 ENSMUST00000050331.6
ENSMUST00000059297.5
 Hnrnph2

heterogeneous nuclear ribonucleoprotein H2

chr16_+_5233615 0.316 ENSMUST00000100196.2
ENSMUST00000049207.8
 Alg1

asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)

chr18_-_31609893 0.313 ENSMUST00000060396.6
 Slc25a46
solute carrier family 25, member 46
chr15_+_80255184 0.300 ENSMUST00000109605.3
 Atf4
activating transcription factor 4
chr3_-_95106779 0.289 ENSMUST00000005768.7
ENSMUST00000107232.2
ENSMUST00000107236.2
 Pip5k1a


phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha


chr1_+_5083105 0.288 ENSMUST00000044369.7
 Atp6v1h
ATPase, H+ transporting, lysosomal V1 subunit H
chr3_-_95106907 0.283 ENSMUST00000107233.2
 Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr8_+_25601591 0.283 ENSMUST00000155861.1
 Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr19_-_7241216 0.246 ENSMUST00000025675.9
 Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr1_+_155158703 0.245 ENSMUST00000027743.7
 Stx6
syntaxin 6
chr5_-_137533170 0.228 ENSMUST00000168746.1
ENSMUST00000170293.1
 Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr19_-_4201591 0.225 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chrX_+_153832225 0.219 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
 Spin2c


spindlin family, member 2C


chr19_-_33392255 0.214 ENSMUST00000096114.5
ENSMUST00000163093.1
 Rnls

renalase, FAD-dependent amine oxidase

chr1_-_75219245 0.214 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr3_-_90052463 0.209 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
 Ubap2l


ubiquitin associated protein 2-like


chr5_+_104046869 0.196 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr16_-_44139196 0.196 ENSMUST00000063661.6
ENSMUST00000114666.2
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chrX_+_134601179 0.193 ENSMUST00000074950.4
ENSMUST00000113203.1
ENSMUST00000113202.1
 Hnrnph2


heterogeneous nuclear ribonucleoprotein H2


chr1_+_166254095 0.192 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr10_+_41519493 0.182 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr3_+_89202916 0.177 ENSMUST00000077367.4
ENSMUST00000167998.1
 Gba

glucosidase, beta, acid

chr5_-_72168142 0.116 ENSMUST00000013693.6
 Commd8
COMM domain containing 8
chr11_+_3649494 0.105 ENSMUST00000093389.2
 Morc2a
microrchidia 2A
chr2_-_37422869 0.104 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr8_+_111033890 0.101 ENSMUST00000034441.7
 Aars
alanyl-tRNA synthetase
chrX_+_136138996 0.074 ENSMUST00000116527.1
 Bex4
brain expressed gene 4
chr3_-_96727566 0.072 ENSMUST00000029741.2
 Polr3c
polymerase (RNA) III (DNA directed) polypeptide C
chr17_+_33824591 0.071 ENSMUST00000048249.6
 Ndufa7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
chr13_-_48625571 0.068 ENSMUST00000035824.9
 Ptpdc1
protein tyrosine phosphatase domain containing 1
chr14_+_26579535 0.066 ENSMUST00000037585.7
 Dennd6a
DENN/MADD domain containing 6A
chr19_-_60790692 0.064 ENSMUST00000025955.6
 Eif3a
eukaryotic translation initiation factor 3, subunit A
chr3_-_96727436 0.061 ENSMUST00000154679.1
 Polr3c
polymerase (RNA) III (DNA directed) polypeptide C
chr5_-_137533212 0.058 ENSMUST00000111038.1
ENSMUST00000143495.1
 Epo
Gnb2
erythropoietin
guanine nucleotide binding protein (G protein), beta 2
chr16_-_92466081 0.035 ENSMUST00000060005.8
 Rcan1
regulator of calcineurin 1
chr3_-_96727453 0.034 ENSMUST00000141377.1
ENSMUST00000125183.1
 Polr3c

polymerase (RNA) III (DNA directed) polypeptide C

chr12_-_91590009 0.023 ENSMUST00000021345.6
 Gtf2a1
general transcription factor II A, 1
chr11_-_117780630 0.020 ENSMUST00000026659.3
ENSMUST00000127227.1
 Tmc6

transmembrane channel-like gene family 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0070829 heterochromatin maintenance(GO:0070829)
0.4 1.6 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055)
0.3 0.8 GO:2000508 regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.2 0.7 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 1.0 GO:0015808 L-alanine transport(GO:0015808)
0.1 1.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.6 GO:0030242 pexophagy(GO:0030242)
0.1 0.9 GO:0001675 acrosome assembly(GO:0001675)
0.1 0.3 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.5 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.1 0.2 GO:0071873 response to norepinephrine(GO:0071873)
0.1 0.9 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.3 GO:0090148 membrane fission(GO:0090148)
0.1 2.0 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 0.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 1.1 GO:0048070 regulation of developmental pigmentation(GO:0048070)
0.0 1.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.6 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.5 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.2 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.0 0.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.2 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.6 GO:0006298 mismatch repair(GO:0006298)
0.0 0.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.1 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.1 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 5.1 GO:0006869 lipid transport(GO:0006869)
0.0 0.6 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 1.0 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 0.3 GO:0034724 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.3 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 0.1 GO:0061470 T follicular helper cell differentiation(GO:0061470)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0032280 symmetric synapse(GO:0032280)
0.2 1.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 2.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 1.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 1.0 GO:0033263 CORVET complex(GO:0033263)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.1 0.8 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 0.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.6 GO:0000800 lateral element(GO:0000800)
0.0 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 1.5 GO:0034399 nuclear periphery(GO:0034399)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.3 1.0 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.6 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 2.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.2 GO:0004348 glucosylceramidase activity(GO:0004348)
0.1 5.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.7 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)