Motif ID: Msx2_Hoxd4

Z-value: 1.882

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_534730740.078.1e-01Click!


Activity profile for motif Msx2_Hoxd4.

activity profile for motif Msx2_Hoxd4


Sorted Z-values histogram for motif Msx2_Hoxd4

Sorted Z-values for motif Msx2_Hoxd4



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_190170671 11.941 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr5_-_62766153 9.929 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_190170178 9.175 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr12_+_38783503 7.210 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr15_-_79285502 6.924 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr10_-_33624587 6.456 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr1_-_163725123 5.011 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr14_-_88471396 4.932 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr2_+_125136692 4.132 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr3_+_68869563 3.947 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr6_-_36811361 3.814 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr14_+_115042752 3.484 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr9_+_22454290 3.015 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr6_+_124304646 2.986 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr2_+_4017727 2.744 ENSMUST00000177457.1
 Frmd4a
FERM domain containing 4A
chr3_+_52268337 2.705 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chrM_+_7759 2.618 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr18_+_52767994 2.598 ENSMUST00000025413.7
ENSMUST00000163742.2
ENSMUST00000178011.1
 Sncaip


synuclein, alpha interacting protein (synphilin)


chr13_+_75967704 2.437 ENSMUST00000022081.1
 Spata9
spermatogenesis associated 9
chr7_-_101845300 2.405 ENSMUST00000094141.5
 Folr2
folate receptor 2 (fetal)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.0 21.1 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.5 6.8 GO:0051764 actin crosslink formation(GO:0051764)
0.1 6.5 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 5.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 5.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 5.0 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
1.3 3.8 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 3.0 GO:0006953 acute-phase response(GO:0006953)
0.2 2.8 GO:0032060 bleb assembly(GO:0032060)
0.3 2.7 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 2.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 2.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.6 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.3 2.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 2.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662) cellular response to fatty acid(GO:0071398)
0.4 2.2 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 2.2 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 2.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.5 1.9 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 1.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 6.9 GO:0071439 clathrin complex(GO:0071439)
0.1 6.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
1.1 4.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 4.3 GO:0070469 respiratory chain(GO:0070469)
0.0 3.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 2.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 2.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 2.4 GO:0005923 bicellular tight junction(GO:0005923)
0.3 2.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.5 1.9 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 1.3 GO:0098536 deuterosome(GO:0098536)
0.1 1.2 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.0 GO:0001940 male pronucleus(GO:0001940)
0.1 0.9 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.9 GO:0043025 neuronal cell body(GO:0043025)
0.1 0.7 GO:0030478 actin cap(GO:0030478)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.6 GO:0031251 PAN complex(GO:0031251)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 21.1 GO:0050693 LBD domain binding(GO:0050693)
0.3 10.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 6.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 6.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 5.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 4.7 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 4.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.3 3.8 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 3.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 3.0 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.2 2.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 2.7 GO:0030674 protein binding, bridging(GO:0030674)
0.8 2.4 GO:0051870 methotrexate binding(GO:0051870)
0.1 2.3 GO:0005504 fatty acid binding(GO:0005504)
0.2 2.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 2.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.3 2.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.4 1.9 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.5 GO:0097109 neuroligin family protein binding(GO:0097109)