Motif ID: Gli1

Z-value: 1.608


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.781.1e-03Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 178 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_64090241 9.761 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090265 8.814 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr11_+_80300866 8.696 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr2_-_54085542 6.544 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr15_-_85581809 6.509 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr12_-_81333129 6.502 ENSMUST00000085238.6
ENSMUST00000182208.1
 Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr12_+_44328882 5.903 ENSMUST00000020939.8
ENSMUST00000110748.2
 Nrcam

neuron-glia-CAM-related cell adhesion molecule

chr6_-_52012476 5.205 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2
chr2_+_118111876 4.388 ENSMUST00000039559.8
 Thbs1
thrombospondin 1
chr4_-_68954351 4.050 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr11_-_119547744 3.404 ENSMUST00000026670.4
 Nptx1
neuronal pentraxin 1
chr15_-_78544345 3.066 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr6_+_107529717 3.062 ENSMUST00000049285.8
 Lrrn1
leucine rich repeat protein 1, neuronal
chr5_+_5573952 2.857 ENSMUST00000101627.2
 Gm8773
predicted gene 8773
chr10_-_63421739 2.754 ENSMUST00000054760.4
 Gm7075
predicted gene 7075
chr10_+_69534039 2.395 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr2_-_30801698 2.331 ENSMUST00000050003.8
 1700001O22Rik
RIKEN cDNA 1700001O22 gene
chr1_+_72824482 2.241 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chrX_+_159303266 2.233 ENSMUST00000112491.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr1_-_25228814 2.186 ENSMUST00000126626.1
 Bai3
brain-specific angiogenesis inhibitor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 18.6 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0 8.2 GO:0016485 protein processing(GO:0016485)
0.0 7.4 GO:0002757 immune response-activating signal transduction(GO:0002757)
2.2 6.5 GO:0072070 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
2.2 6.5 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 6.5 GO:0007050 cell cycle arrest(GO:0007050)
2.1 6.4 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.5 6.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.0 5.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 5.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.3 5.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.3 4.1 GO:0042711 maternal behavior(GO:0042711)
0.9 3.7 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
1.1 3.4 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1 3.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 3.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.7 2.9 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.7 2.2 GO:0016191 synaptic vesicle uncoating(GO:0016191) regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
0.4 2.2 GO:1900451 rhythmic synaptic transmission(GO:0060024) terminal button organization(GO:0072553) positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of protein localization to synapse(GO:1902474) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.2 2.2 GO:1901898 regulation of cell communication by electrical coupling(GO:0010649) negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.9 GO:0043194 axon initial segment(GO:0043194)
0.0 11.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 7.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 7.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 6.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 6.5 GO:0031594 neuromuscular junction(GO:0031594)
1.5 4.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 3.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.5 3.7 GO:0042825 TAP complex(GO:0042825)
0.2 2.9 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 2.2 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.1 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 2.1 GO:0031941 filamentous actin(GO:0031941)
0.1 2.0 GO:0097228 sperm principal piece(GO:0097228)
0.0 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.9 GO:0031209 SCAR complex(GO:0031209)
0.0 1.8 GO:0060170 ciliary membrane(GO:0060170)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 8.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.6 6.5 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.8 6.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.2 6.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.2 5.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 5.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 5.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
1.5 4.4 GO:0070052 collagen V binding(GO:0070052)
0.9 3.7 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.1 3.3 GO:0032452 histone demethylase activity(GO:0032452)
1.0 3.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 2.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 2.2 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.3 2.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 2.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 2.2 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.5 2.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 2.1 GO:0045505 dynein intermediate chain binding(GO:0045505)