Motif ID: Esr2

Z-value: 2.286


Transcription factors associated with Esr2:

Gene SymbolEntrez IDGene Name
Esr2 ENSMUSG00000021055.7 Esr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr2mm10_v2_chr12_-_76177251_761772650.371.9e-01Click!


Activity profile for motif Esr2.

activity profile for motif Esr2


Sorted Z-values histogram for motif Esr2

Sorted Z-values for motif Esr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_25470031 5.630 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr4_-_136892867 5.553 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr2_-_25469742 5.120 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr18_+_20665250 5.024 ENSMUST00000075312.3
 Ttr
transthyretin
chr6_+_90550789 3.632 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr11_+_78499087 3.594 ENSMUST00000017488.4
 Vtn
vitronectin
chr14_-_31168587 3.112 ENSMUST00000036618.7
 Stab1
stabilin 1
chr5_-_116422858 2.837 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr7_-_126625676 2.746 ENSMUST00000032961.3
 Nupr1
nuclear protein transcription regulator 1
chr8_-_122432924 2.646 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr19_+_8591254 2.547 ENSMUST00000010251.3
ENSMUST00000170817.1
 Slc22a8

solute carrier family 22 (organic anion transporter), member 8

chr7_-_142578093 2.541 ENSMUST00000149974.1
ENSMUST00000152754.1
 H19

H19 fetal liver mRNA

chr13_+_38345716 2.500 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr7_-_19698383 2.482 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr17_-_34000257 2.270 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
 H2-K1




histocompatibility 2, K1, K region




chr6_-_35308110 2.222 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr6_-_124779686 2.206 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr7_-_31054815 2.183 ENSMUST00000071697.4
ENSMUST00000108110.3
 Fxyd1

FXYD domain-containing ion transport regulator 1

chr4_+_155839724 2.170 ENSMUST00000030947.3
 Mxra8
matrix-remodelling associated 8
chr7_-_19698206 2.160 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 796 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 11.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.0 6.7 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.0 5.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.5 4.7 GO:0097421 liver regeneration(GO:0097421)
1.5 4.6 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.4 4.5 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.3 4.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.2 4.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 3.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
1.3 3.8 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
1.2 3.6 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.1 3.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 3.4 GO:0097460 ferrous iron import into cell(GO:0097460)
1.1 3.3 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.8 3.3 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 3.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.0 3.1 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.2 3.1 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.3 3.0 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.9 2.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 274 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 39.5 GO:0005615 extracellular space(GO:0005615)
0.0 10.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 9.3 GO:0005581 collagen trimer(GO:0005581)
0.1 9.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 8.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 8.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 8.1 GO:0005840 ribosome(GO:0005840)
0.2 7.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 6.5 GO:0005901 caveola(GO:0005901)
0.0 5.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 5.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.4 5.1 GO:0042612 MHC class I protein complex(GO:0042612)
1.5 4.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 4.4 GO:0070469 respiratory chain(GO:0070469)
0.2 4.1 GO:0031231 intrinsic component of peroxisomal membrane(GO:0031231)
0.8 3.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 3.4 GO:0005844 polysome(GO:0005844)
0.1 3.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.8 3.1 GO:0043020 NADPH oxidase complex(GO:0043020)
1.0 3.0 GO:0005584 collagen type I trimer(GO:0005584)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 462 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.7 GO:0003735 structural constituent of ribosome(GO:0003735)
2.8 11.0 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.2 9.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 8.3 GO:0005044 scavenger receptor activity(GO:0005044)
1.0 7.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 6.0 GO:0005080 protein kinase C binding(GO:0005080)
0.5 5.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.8 4.8 GO:0015375 glycine:sodium symporter activity(GO:0015375)
1.5 4.6 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.3 4.6 GO:0046977 TAP binding(GO:0046977)
0.3 4.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 4.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 4.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.8 4.0 GO:0019864 IgG binding(GO:0019864)
0.3 3.9 GO:0005537 mannose binding(GO:0005537)
0.1 3.9 GO:0005179 hormone activity(GO:0005179)
0.3 3.8 GO:0008430 selenium binding(GO:0008430)
1.2 3.6 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.5 3.4 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.5 3.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)