Motif ID: Maff

Z-value: 1.048


Transcription factors associated with Maff:

Gene SymbolEntrez IDGene Name
Maff ENSMUSG00000042622.7 Maff

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maffmm10_v2_chr15_+_79348061_793481540.621.8e-02Click!


Activity profile for motif Maff.

activity profile for motif Maff


Sorted Z-values histogram for motif Maff

Sorted Z-values for motif Maff



Network of associatons between targets according to the STRING database.



First level regulatory network of Maff

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_136886187 7.455 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr7_-_110862944 7.428 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr15_+_3270767 4.590 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr18_+_33464163 3.663 ENSMUST00000097634.3
 Gm10549
predicted gene 10549
chr13_-_23710714 3.607 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr11_+_82101836 2.949 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr17_-_25570678 2.918 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr5_+_104435112 2.263 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr19_+_8929628 1.854 ENSMUST00000096241.4
 Eml3
echinoderm microtubule associated protein like 3
chr13_+_48261427 1.833 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr3_+_109573907 1.753 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr11_-_109473598 1.639 ENSMUST00000070152.5
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr3_-_59262825 1.595 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr7_-_100964371 1.532 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr14_+_20929416 1.429 ENSMUST00000022369.7
 Vcl
vinculin
chr4_-_143299498 1.216 ENSMUST00000030317.7
 Pdpn
podoplanin
chr9_-_122310921 1.101 ENSMUST00000180685.1
 Gm26797
predicted gene, 26797
chr14_+_118787894 1.030 ENSMUST00000047761.6
ENSMUST00000071546.7
 Cldn10

claudin 10

chr17_-_67950908 0.983 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr19_-_8929323 0.965 ENSMUST00000096242.3
 Rom1
rod outer segment membrane protein 1
chr2_-_130397525 0.907 ENSMUST00000028897.7
 Cpxm1
carboxypeptidase X 1 (M14 family)
chr16_-_22439719 0.902 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr1_+_136017967 0.885 ENSMUST00000063719.8
ENSMUST00000118832.1
 Tmem9

transmembrane protein 9

chr1_+_136018062 0.835 ENSMUST00000117950.1
 Tmem9
transmembrane protein 9
chr1_-_120074023 0.791 ENSMUST00000056089.7
 Tmem37
transmembrane protein 37
chr6_+_120773633 0.789 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr7_+_16944645 0.773 ENSMUST00000094807.5
 Pnmal2
PNMA-like 2
chr4_-_143299463 0.759 ENSMUST00000119654.1
 Pdpn
podoplanin
chr8_+_25532125 0.738 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1
chr7_+_30314810 0.632 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
 Syne4



spectrin repeat containing, nuclear envelope family member 4



chr12_+_35047180 0.594 ENSMUST00000048519.9
ENSMUST00000163677.1
 Snx13

sorting nexin 13

chr5_-_135251209 0.575 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr18_+_60963517 0.511 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr15_-_78572754 0.495 ENSMUST00000043214.6
 Rac2
RAS-related C3 botulinum substrate 2
chr8_+_46739745 0.481 ENSMUST00000034041.7
 Irf2
interferon regulatory factor 2
chr6_+_30401866 0.477 ENSMUST00000068240.6
ENSMUST00000068259.6
 Klhdc10

kelch domain containing 10

chr5_+_110839973 0.471 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr16_-_16560201 0.459 ENSMUST00000162045.1
ENSMUST00000162124.1
ENSMUST00000161861.1
 Fgd4


FYVE, RhoGEF and PH domain containing 4


chr2_-_69206133 0.429 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_-_69206146 0.375 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr5_-_67815852 0.287 ENSMUST00000141443.1
 Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr4_-_139352538 0.272 ENSMUST00000102503.3
 Mrto4
MRT4, mRNA turnover 4, homolog (S. cerevisiae)
chr11_-_116086929 0.266 ENSMUST00000074628.6
ENSMUST00000106444.3
 Wbp2

WW domain binding protein 2

chr18_-_33464007 0.256 ENSMUST00000168890.1
 Nrep
neuronal regeneration related protein
chr19_-_4042165 0.224 ENSMUST00000042700.9
 Gstp2
glutathione S-transferase, pi 2
chr4_-_25281752 0.224 ENSMUST00000038705.7
 Ufl1
UFM1 specific ligase 1
chr5_+_106964319 0.218 ENSMUST00000031221.5
ENSMUST00000117196.2
ENSMUST00000076467.6
 Cdc7


cell division cycle 7 (S. cerevisiae)


chr7_-_44997535 0.207 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr4_-_139352298 0.202 ENSMUST00000030513.6
ENSMUST00000155257.1
 Mrto4

MRT4, mRNA turnover 4, homolog (S. cerevisiae)

chr15_-_33687840 0.188 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chr18_+_32377176 0.187 ENSMUST00000091967.5
ENSMUST00000025239.7
 Bin1

bridging integrator 1

chr1_+_75382114 0.181 ENSMUST00000113590.1
ENSMUST00000148515.1
 Speg

SPEG complex locus

chr2_+_121867083 0.179 ENSMUST00000089912.5
ENSMUST00000089915.3
 Casc4

cancer susceptibility candidate 4

chr9_+_65214690 0.163 ENSMUST00000069000.7
 Parp16
poly (ADP-ribose) polymerase family, member 16
chr2_+_121866918 0.162 ENSMUST00000078752.3
ENSMUST00000110586.3
 Casc4

cancer susceptibility candidate 4

chr18_-_33463747 0.149 ENSMUST00000171533.1
 Nrep
neuronal regeneration related protein
chr2_-_127831817 0.147 ENSMUST00000028858.7
 Bub1
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
chr15_+_99972780 0.145 ENSMUST00000100206.2
 Larp4
La ribonucleoprotein domain family, member 4
chr3_-_116614587 0.137 ENSMUST00000041524.4
 Trmt13
tRNA methyltransferase 13
chr11_+_75651504 0.134 ENSMUST00000069057.6
 Myo1c
myosin IC
chr5_-_35525691 0.125 ENSMUST00000038676.5
 Cpz
carboxypeptidase Z
chr11_-_106272927 0.101 ENSMUST00000021052.9
 Smarcd2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr15_-_25413752 0.086 ENSMUST00000058845.7
 Basp1
brain abundant, membrane attached signal protein 1
chr16_-_16560046 0.068 ENSMUST00000172181.2
 Fgd4
FYVE, RhoGEF and PH domain containing 4
chr11_-_120630516 0.060 ENSMUST00000106181.1
 Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr11_-_77078404 0.052 ENSMUST00000102494.1
 Ccdc55
coiled-coil domain containing 55
chr4_-_25281801 0.041 ENSMUST00000102994.3
 Ufl1
UFM1 specific ligase 1
chr18_-_33463615 0.039 ENSMUST00000051087.8
 Nrep
neuronal regeneration related protein
chr18_+_4921662 0.039 ENSMUST00000143254.1
 Svil
supervillin
chr17_+_26138661 0.023 ENSMUST00000074370.3
ENSMUST00000118904.2
ENSMUST00000163421.1
 Axin1


axin 1


chr3_-_108044801 0.023 ENSMUST00000178808.1
ENSMUST00000106670.1
ENSMUST00000029489.8
 Gstm4


glutathione S-transferase, mu 4


chr6_+_83794974 0.022 ENSMUST00000037376.7
 Nagk
N-acetylglucosamine kinase
chr11_+_82115180 0.008 ENSMUST00000009329.2
 Ccl8
chemokine (C-C motif) ligand 8
chr4_+_139352587 0.001 ENSMUST00000147999.1
ENSMUST00000042096.7
ENSMUST00000179784.1
ENSMUST00000082262.7
 Ubr4
Emc1


ubiquitin protein ligase E3 component n-recognin 4
ER membrane protein complex subunit 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
1.0 2.9 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
1.0 2.9 GO:0072034 renal vesicle induction(GO:0072034)
0.9 7.4 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.7 4.6 GO:0001887 selenium compound metabolic process(GO:0001887)
0.5 1.6 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.5 1.5 GO:0030321 transepithelial chloride transport(GO:0030321)
0.5 1.8 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.4 7.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 1.2 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.2 1.0 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 2.3 GO:0033280 response to vitamin D(GO:0033280)
0.2 2.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.2 0.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.5 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.1 1.6 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 1.4 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 1.8 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1 0.6 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 1.0 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 0.5 GO:0030035 microspike assembly(GO:0030035)
0.0 0.3 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.3 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.5 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.3 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0 0.2 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:1990357 terminal web(GO:1990357)
0.1 0.8 GO:0031262 Ndc80 complex(GO:0031262)
0.1 1.4 GO:0005916 fascia adherens(GO:0005916)
0.1 7.5 GO:0005581 collagen trimer(GO:0005581)
0.1 1.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0045160 myosin I complex(GO:0045160)
0.0 0.6 GO:0031527 filopodium membrane(GO:0031527)
0.0 2.5 GO:0030175 filopodium(GO:0030175)
0.0 1.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.2 GO:0043196 varicosity(GO:0043196)
0.0 3.8 GO:0045177 apical part of cell(GO:0045177)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.4 3.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.4 7.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 3.6 GO:0039706 co-receptor binding(GO:0039706)
0.3 4.6 GO:0008430 selenium binding(GO:0008430)
0.2 2.0 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.1 1.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.3 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 2.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.5 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 3.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)