Motif ID: Hey2

Z-value: 1.038


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_308428010.146.3e-01Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

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Top targets:


Showing 1 to 20 of 175 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_116532441 2.934 ENSMUST00000106386.1
ENSMUST00000145737.1
ENSMUST00000155102.1
ENSMUST00000063446.6
 Sphk1



sphingosine kinase 1



chr7_-_66427469 2.677 ENSMUST00000015278.7
 Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr15_+_57694651 2.422 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr10_+_128909866 2.407 ENSMUST00000026407.7
 Cd63
CD63 antigen
chr2_-_180104463 2.363 ENSMUST00000056480.3
 Hrh3
histamine receptor H3
chr15_+_52040107 2.064 ENSMUST00000090025.4
 Aard
alanine and arginine rich domain containing protein
chr7_+_35119285 1.980 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr2_-_114013619 1.898 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr1_+_120340569 1.875 ENSMUST00000037286.8
 C1ql2
complement component 1, q subcomponent-like 2
chr8_+_65618009 1.856 ENSMUST00000110258.1
ENSMUST00000110256.1
ENSMUST00000110255.1
 March1


membrane-associated ring finger (C3HC4) 1


chr4_+_117835387 1.670 ENSMUST00000169885.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr15_-_58076456 1.616 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1

chr8_+_119446719 1.539 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr16_+_33829624 1.519 ENSMUST00000115028.3
 Itgb5
integrin beta 5
chr9_-_54661870 1.380 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr5_+_111733924 1.358 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr11_+_120721452 1.344 ENSMUST00000018156.5
 Rac3
RAS-related C3 botulinum substrate 3
chr11_+_120721543 1.305 ENSMUST00000142229.1
 Rac3
RAS-related C3 botulinum substrate 3
chr1_-_152766281 1.249 ENSMUST00000111859.1
ENSMUST00000148865.1
 Rgl1

ral guanine nucleotide dissociation stimulator,-like 1

chr5_+_135168382 1.239 ENSMUST00000111187.3
ENSMUST00000111188.1
 Bcl7b

B cell CLL/lymphoma 7B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.9 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.9 2.7 GO:0060166 olfactory pit development(GO:0060166)
0.3 2.6 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.8 2.4 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.5 2.4 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.0 2.4 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 2.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 2.0 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 1.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 1.9 GO:0007601 visual perception(GO:0007601)
0.6 1.7 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.4 1.7 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.1 1.5 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.3 1.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 1.1 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 1.1 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.2 1.0 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
0.1 1.0 GO:0010454 negative regulation of cell fate commitment(GO:0010454)
0.3 0.9 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.1 0.9 GO:0007190 activation of adenylate cyclase activity(GO:0007190)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0008021 synaptic vesicle(GO:0008021)
0.6 2.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 2.3 GO:0043209 myelin sheath(GO:0043209)
0.7 2.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.1 1.9 GO:0005922 connexon complex(GO:0005922)
0.1 1.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 1.7 GO:0005638 lamin filament(GO:0005638)
0.5 1.5 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 1.4 GO:0031941 filamentous actin(GO:0031941)
0.1 1.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.9 GO:0005604 basement membrane(GO:0005604)
0.1 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.6 GO:0005902 microvillus(GO:0005902)
0.1 0.5 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.7 2.9 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.5 2.7 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 2.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 2.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.4 2.4 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 2.0 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 2.0 GO:0005178 integrin binding(GO:0005178)
0.2 1.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 1.7 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.1 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.1 1.1 GO:0042287 MHC protein binding(GO:0042287)
0.2 1.0 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.3 0.9 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.3 0.9 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.9 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)