Motif ID: Nkx2-3

Z-value: 0.719


Transcription factors associated with Nkx2-3:

Gene SymbolEntrez IDGene Name
Nkx2-3 ENSMUSG00000044220.12 Nkx2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_436123250.391.7e-01Click!


Activity profile for motif Nkx2-3.

activity profile for motif Nkx2-3


Sorted Z-values histogram for motif Nkx2-3

Sorted Z-values for motif Nkx2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_136171722 0.789 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr15_-_43869993 0.716 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr6_-_99044414 0.694 ENSMUST00000177507.1
ENSMUST00000123992.1
 Foxp1

forkhead box P1

chr16_+_78930940 0.684 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr14_-_118052235 0.660 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr9_+_32116040 0.623 ENSMUST00000174641.1
 Arhgap32
Rho GTPase activating protein 32
chr14_+_75455957 0.618 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr15_+_92597104 0.609 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr12_+_38780284 0.582 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr13_+_83504032 0.560 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr6_-_99266494 0.556 ENSMUST00000113326.2
 Foxp1
forkhead box P1
chr8_-_48555846 0.555 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr15_-_13173607 0.554 ENSMUST00000036439.4
 Cdh6
cadherin 6
chr5_-_73191848 0.545 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr3_+_55461758 0.538 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr13_-_113663670 0.538 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr3_+_134236483 0.535 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr3_+_138065052 0.520 ENSMUST00000163080.2
 1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr11_-_37235882 0.497 ENSMUST00000102801.1
 Tenm2
teneurin transmembrane protein 2
chr4_-_36056726 0.480 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 1.1 GO:0097264 self proteolysis(GO:0097264)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.8 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.8 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 0.7 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 0.6 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 0.6 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 0.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.6 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.6 GO:0021954 central nervous system neuron development(GO:0021954)
0.2 0.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.5 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.5 GO:0021830 interneuron migration from the subpallium to the cortex(GO:0021830)
0.1 0.5 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.4 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.4 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 0.4 GO:0046684 response to pyrethroid(GO:0046684)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.5 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.0 0.4 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.6 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.5 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.4 GO:0048185 activin binding(GO:0048185)
0.0 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.4 GO:0031402 sodium ion binding(GO:0031402)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)