Motif ID: Tfap2e

Z-value: 0.887


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.253.9e-01Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

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Top targets:


Showing 1 to 20 of 75 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102897123 5.037 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr11_-_102897146 2.812 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr7_-_19629355 2.679 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
 Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr8_+_94152607 2.343 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr3_-_113630068 1.918 ENSMUST00000092154.3
ENSMUST00000106536.1
ENSMUST00000106535.1
 Rnpc3


RNA-binding region (RNP1, RRM) containing 3


chr15_-_97831460 1.900 ENSMUST00000079838.7
ENSMUST00000118294.1
 Hdac7

histone deacetylase 7

chr15_-_102524615 1.870 ENSMUST00000023814.7
 Npff
neuropeptide FF-amide peptide precursor
chr2_+_91945703 1.689 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr16_-_46496772 1.677 ENSMUST00000149901.1
ENSMUST00000096052.2
 Pvrl3

poliovirus receptor-related 3

chr6_-_137649211 1.462 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
 Eps8


epidermal growth factor receptor pathway substrate 8


chr13_+_37826225 1.379 ENSMUST00000128570.1
 Rreb1
ras responsive element binding protein 1
chr11_+_101260569 1.194 ENSMUST00000103108.1
 Wnk4
WNK lysine deficient protein kinase 4
chr2_-_129297205 1.100 ENSMUST00000052708.6
 Ckap2l
cytoskeleton associated protein 2-like
chr16_-_46496955 1.089 ENSMUST00000023335.6
ENSMUST00000023334.8
 Pvrl3

poliovirus receptor-related 3

chr13_-_111490028 1.041 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490111 1.035 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr8_+_41239718 0.937 ENSMUST00000045218.7
 Pcm1
pericentriolar material 1
chr13_-_101768154 0.891 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr17_-_85688252 0.863 ENSMUST00000024947.7
ENSMUST00000163568.2
 Six2

sine oculis-related homeobox 2

chr6_+_108213086 0.862 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 7.8 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.3 2.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 2.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.8 2.3 GO:0097212 lysosomal membrane organization(GO:0097212)
0.2 1.9 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.4 1.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 1.4 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.4 1.2 GO:0003096 renal sodium ion transport(GO:0003096)
0.1 1.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 0.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 0.9 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.1 0.9 GO:0042045 epithelial fluid transport(GO:0042045)
0.0 0.9 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 0.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.6 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 0.5 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.2 0.5 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.2 0.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.2 0.5 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 7.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.4 2.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 2.3 GO:0008021 synaptic vesicle(GO:0008021)
0.1 1.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.9 GO:0043204 perikaryon(GO:0043204)
0.1 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 0.9 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.9 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 0.5 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 0.4 GO:0005940 septin ring(GO:0005940)
0.1 0.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.1 GO:0034464 BBSome(GO:0034464)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 1.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 1.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 1.5 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 1.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 1.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 1.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.0 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.3 0.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 0.9 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.6 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.4 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.3 GO:0097016 L27 domain binding(GO:0097016)