Motif ID: Tfap2e

Z-value: 0.887


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.253.9e-01Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_102897123 5.037 ENSMUST00000067444.3
Gfap
glial fibrillary acidic protein
chr11_-_102897146 2.812 ENSMUST00000077902.4
Gfap
glial fibrillary acidic protein
chr7_-_19629355 2.679 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr8_+_94152607 2.343 ENSMUST00000034211.8
Mt3
metallothionein 3
chr3_-_113630068 1.918 ENSMUST00000092154.3
ENSMUST00000106536.1
ENSMUST00000106535.1
Rnpc3


RNA-binding region (RNP1, RRM) containing 3


chr15_-_97831460 1.900 ENSMUST00000079838.7
ENSMUST00000118294.1
Hdac7

histone deacetylase 7

chr15_-_102524615 1.870 ENSMUST00000023814.7
Npff
neuropeptide FF-amide peptide precursor
chr2_+_91945703 1.689 ENSMUST00000178895.1
Gm9821
predicted gene 9821
chr16_-_46496772 1.677 ENSMUST00000149901.1
ENSMUST00000096052.2
Pvrl3

poliovirus receptor-related 3

chr6_-_137649211 1.462 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
Eps8


epidermal growth factor receptor pathway substrate 8


chr13_+_37826225 1.379 ENSMUST00000128570.1
Rreb1
ras responsive element binding protein 1
chr11_+_101260569 1.194 ENSMUST00000103108.1
Wnk4
WNK lysine deficient protein kinase 4
chr2_-_129297205 1.100 ENSMUST00000052708.6
Ckap2l
cytoskeleton associated protein 2-like
chr16_-_46496955 1.089 ENSMUST00000023335.6
ENSMUST00000023334.8
Pvrl3

poliovirus receptor-related 3

chr13_-_111490028 1.041 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490111 1.035 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr8_+_41239718 0.937 ENSMUST00000045218.7
Pcm1
pericentriolar material 1
chr13_-_101768154 0.891 ENSMUST00000055518.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr17_-_85688252 0.863 ENSMUST00000024947.7
ENSMUST00000163568.2
Six2

sine oculis-related homeobox 2

chr6_+_108213086 0.862 ENSMUST00000032192.6
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr2_+_102658640 0.674 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr9_+_100643605 0.614 ENSMUST00000041418.6
Stag1
stromal antigen 1
chrX_+_7722267 0.611 ENSMUST00000125991.1
ENSMUST00000148624.1
Wdr45

WD repeat domain 45

chr2_-_38287174 0.594 ENSMUST00000130472.1
Dennd1a
DENN/MADD domain containing 1A
chr9_-_121759788 0.559 ENSMUST00000181325.1
E530011L22Rik
RIKEN cDNA E530011L22 gene
chr17_-_79020816 0.559 ENSMUST00000168887.1
ENSMUST00000119284.1
Prkd3

protein kinase D3

chrX_+_7723278 0.557 ENSMUST00000144148.1
Wdr45
WD repeat domain 45
chr4_-_149774238 0.539 ENSMUST00000105686.2
Slc25a33
solute carrier family 25, member 33
chr2_-_153015331 0.514 ENSMUST00000028972.8
Pdrg1
p53 and DNA damage regulated 1
chr7_-_116443439 0.506 ENSMUST00000170430.1
Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
chr5_-_137314175 0.504 ENSMUST00000024119.9
Trip6
thyroid hormone receptor interactor 6
chr5_-_34187670 0.500 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr3_-_94786430 0.488 ENSMUST00000107272.1
Cgn
cingulin
chr4_+_42158092 0.479 ENSMUST00000098122.2
Gm13306
predicted gene 13306
chr9_-_97111117 0.473 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr15_-_58214882 0.453 ENSMUST00000022986.6
Fbxo32
F-box protein 32
chr13_+_30659999 0.443 ENSMUST00000091672.6
ENSMUST00000110310.1
ENSMUST00000095914.5
Dusp22


dual specificity phosphatase 22


chr6_-_39725448 0.434 ENSMUST00000002487.8
Braf
Braf transforming gene
chr6_-_97617536 0.434 ENSMUST00000113355.2
Frmd4b
FERM domain containing 4B
chr3_-_84040151 0.427 ENSMUST00000052342.7
D930015E06Rik
RIKEN cDNA D930015E06 gene
chr14_+_122475397 0.421 ENSMUST00000075888.5
Zic2
zinc finger protein of the cerebellum 2
chr2_+_22895583 0.412 ENSMUST00000152170.1
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr3_-_94786469 0.409 ENSMUST00000107273.1
Cgn
cingulin
chr9_+_25252439 0.401 ENSMUST00000115272.2
ENSMUST00000165594.2
Sept7

septin 7

chr17_+_37046555 0.371 ENSMUST00000172789.1
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr5_+_64970069 0.360 ENSMUST00000031080.8
Fam114a1
family with sequence similarity 114, member A1
chrX_+_73716577 0.353 ENSMUST00000002084.7
Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr9_+_100643448 0.318 ENSMUST00000146312.1
ENSMUST00000129269.1
Stag1

stromal antigen 1

chr19_-_42752710 0.302 ENSMUST00000076505.3
Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr7_+_141447645 0.266 ENSMUST00000106004.1
ENSMUST00000106003.1
Rplp2

ribosomal protein, large P2

chr2_+_109890846 0.266 ENSMUST00000028583.7
Lin7c
lin-7 homolog C (C. elegans)
chr2_-_150904620 0.258 ENSMUST00000056149.8
Abhd12
abhydrolase domain containing 12
chr2_-_6935081 0.256 ENSMUST00000100426.2
Gm10855
predicted gene 10855
chr8_-_111854278 0.231 ENSMUST00000034432.5
Cfdp1
craniofacial development protein 1
chr19_+_42518795 0.229 ENSMUST00000160107.1
ENSMUST00000160893.1
R3hcc1l

R3H domain and coiled-coil containing 1 like

chr1_+_74771886 0.213 ENSMUST00000006716.6
Wnt6
wingless-related MMTV integration site 6
chrX_-_103981242 0.206 ENSMUST00000121153.1
ENSMUST00000070705.4
Rlim

ring finger protein, LIM domain interacting

chr8_+_109705549 0.196 ENSMUST00000034163.8
Zfp821
zinc finger protein 821
chr3_+_103914560 0.193 ENSMUST00000106806.1
Rsbn1
rosbin, round spermatid basic protein 1
chr17_+_24896488 0.189 ENSMUST00000024978.6
Nme3
NME/NM23 nucleoside diphosphate kinase 3
chr12_+_3572379 0.184 ENSMUST00000173199.1
ENSMUST00000164578.2
ENSMUST00000174479.1
ENSMUST00000173240.1
ENSMUST00000174663.1
ENSMUST00000173736.1
Dtnb





dystrobrevin, beta





chrX_+_73716712 0.156 ENSMUST00000114461.2
Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr19_-_53944621 0.145 ENSMUST00000135402.2
Bbip1
BBSome interacting protein 1
chr8_-_84687839 0.125 ENSMUST00000001975.4
Nacc1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr1_+_86526688 0.122 ENSMUST00000045897.8
Ptma
prothymosin alpha
chr19_+_42518759 0.111 ENSMUST00000026188.3
R3hcc1l
R3H domain and coiled-coil containing 1 like
chr1_-_177796451 0.102 ENSMUST00000016105.8
Adss
adenylosuccinate synthetase, non muscle
chr14_+_32599922 0.101 ENSMUST00000068938.5
Prrxl1
paired related homeobox protein-like 1
chr8_+_107293463 0.083 ENSMUST00000169453.1
Nfat5
nuclear factor of activated T cells 5
chr10_-_7663245 0.072 ENSMUST00000163085.1
ENSMUST00000159917.1
Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr12_+_109544498 0.067 ENSMUST00000126289.1
Meg3
maternally expressed 3
chr1_+_159737510 0.062 ENSMUST00000111669.3
Tnr
tenascin R
chr5_+_28165690 0.048 ENSMUST00000036177.7
En2
engrailed 2
chr3_-_88455302 0.015 ENSMUST00000125526.1
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr11_+_95414078 0.009 ENSMUST00000107724.2
ENSMUST00000150884.1
ENSMUST00000107722.1
ENSMUST00000127713.1
Spop



speckle-type POZ protein




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.8 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.8 2.3 GO:0097212 lysosomal membrane organization(GO:0097212)
0.4 1.2 GO:0003096 renal sodium ion transport(GO:0003096)
0.4 1.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.3 2.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 0.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 2.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.2 0.9 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.2 0.4 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.2 1.9 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.2 0.5 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.2 1.4 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.2 0.5 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.2 0.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.2 0.5 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.9 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 0.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.4 GO:1900145 regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900175) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.1 0.6 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.2 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 0.4 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.4 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.2 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 0.4 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.5 GO:0006862 nucleotide transport(GO:0006862)
0.0 0.2 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.3 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.9 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.2 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0 0.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0021559 trigeminal nerve development(GO:0021559)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 7.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.4 2.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 0.9 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.4 GO:0005940 septin ring(GO:0005940)
0.1 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 1.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.5 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.9 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.6 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.9 GO:0043204 perikaryon(GO:0043204)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)
0.0 2.3 GO:0008021 synaptic vesicle(GO:0008021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 0.9 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 1.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.4 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 0.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 7.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.0 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.1 1.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 1.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.5 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.6 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)