Motif ID: Klf12_Klf14_Sp4

Z-value: 0.880

Transcription factors associated with Klf12_Klf14_Sp4:

Gene SymbolEntrez IDGene Name
Klf12 ENSMUSG00000072294.4 Klf12
Klf14 ENSMUSG00000073209.3 Klf14
Sp4 ENSMUSG00000025323.9 Sp4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf12mm10_v2_chr14_-_100149764_100149764-0.696.8e-03Click!
Sp4mm10_v2_chr12_-_118301429_118301458-0.204.9e-01Click!


Activity profile for motif Klf12_Klf14_Sp4.

activity profile for motif Klf12_Klf14_Sp4


Sorted Z-values histogram for motif Klf12_Klf14_Sp4

Sorted Z-values for motif Klf12_Klf14_Sp4



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf12_Klf14_Sp4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_58076456 3.049 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1

chr11_-_100759740 2.593 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_-_100759942 2.441 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr7_-_19118357 2.188 ENSMUST00000141380.1
 Gm4969
predicted gene 4969
chr11_+_3514861 1.871 ENSMUST00000094469.4
 Selm
selenoprotein M
chr15_-_58076425 1.667 ENSMUST00000176935.1
 9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr7_-_19629355 1.534 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
 Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr3_+_118433797 1.531 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr11_-_121204626 1.476 ENSMUST00000026169.6
 Ogfod3
2-oxoglutarate and iron-dependent oxygenase domain containing 3
chr16_-_8672145 1.457 ENSMUST00000008537.8
 Carhsp1
calcium regulated heat stable protein 1
chr17_+_33916171 1.413 ENSMUST00000053429.9
 Zbtb22
zinc finger and BTB domain containing 22
chr2_+_25395866 1.390 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr4_+_136206365 1.323 ENSMUST00000047526.7
 Asap3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr5_-_140389188 1.293 ENSMUST00000031539.7
 Snx8
sorting nexin 8
chr11_+_78322965 1.271 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr12_+_17690793 1.256 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr10_+_86300372 1.254 ENSMUST00000020234.7
 Timp3
tissue inhibitor of metalloproteinase 3
chr2_+_79635352 1.248 ENSMUST00000111785.2
 Ssfa2
sperm specific antigen 2
chr2_+_79635416 1.238 ENSMUST00000111788.1
 Ssfa2
sperm specific antigen 2
chr11_+_116532441 1.234 ENSMUST00000106386.1
ENSMUST00000145737.1
ENSMUST00000155102.1
ENSMUST00000063446.6
 Sphk1



sphingosine kinase 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 544 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.9 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 2.3 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 2.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.5 1.9 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.5 1.9 GO:0035934 corticosterone secretion(GO:0035934)
0.3 1.9 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.1 1.6 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 1.6 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 1.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 1.5 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2 1.4 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.1 1.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 1.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.3 GO:0006414 translational elongation(GO:0006414)
0.0 1.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.3 GO:0006821 chloride transport(GO:0006821)
0.3 1.2 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.2 1.2 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.2 1.2 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.2 1.2 GO:0006703 estrogen biosynthetic process(GO:0006703)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.9 GO:0000796 condensin complex(GO:0000796)
0.0 2.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 2.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 2.3 GO:0005605 basal lamina(GO:0005605)
0.6 1.9 GO:0000802 transverse filament(GO:0000802)
0.2 1.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.2 1.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 1.6 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 1.4 GO:0031941 filamentous actin(GO:0031941)
0.0 1.3 GO:0030904 retromer complex(GO:0030904)
0.0 1.3 GO:0005604 basement membrane(GO:0005604)
0.2 1.2 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 1.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.2 GO:0070469 respiratory chain(GO:0070469)
0.1 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 1.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.0 GO:0001673 male germ cell nucleus(GO:0001673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 334 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.1 GO:0051015 actin filament binding(GO:0051015)
0.0 4.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 4.2 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 3.0 GO:0005125 cytokine activity(GO:0005125)
0.2 2.0 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.7 GO:0008083 growth factor activity(GO:0008083)
0.0 1.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.6 GO:0043621 protein self-association(GO:0043621)
0.1 1.5 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 1.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.3 1.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.3 1.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.3 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 1.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 1.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.2 GO:0033677 DNA/RNA helicase activity(GO:0033677)