Motif ID: Rfx5

Z-value: 0.477


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.669.7e-03Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_34187545 0.656 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34187789 0.642 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_+_117523526 0.496 ENSMUST00000132261.1
 Gm11734
predicted gene 11734
chr7_-_19692596 0.385 ENSMUST00000108451.2
ENSMUST00000045035.4
 Apoc1

apolipoprotein C-I

chr17_+_35861343 0.363 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr10_-_19011948 0.361 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr9_-_21291124 0.346 ENSMUST00000086374.6
 Cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr8_-_89187560 0.340 ENSMUST00000093326.2
 Gm5356
predicted pseudogene 5356
chr1_-_183147461 0.327 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr14_+_55618023 0.320 ENSMUST00000002395.7
 Rec8
REC8 homolog (yeast)
chr17_+_34398802 0.309 ENSMUST00000114175.1
ENSMUST00000078615.5
ENSMUST00000139063.1
ENSMUST00000097348.2
 BC051142



cDNA sequence BC051142



chr8_-_85067982 0.286 ENSMUST00000177563.1
 Gm5741
predicted gene 5741
chr17_+_34263209 0.285 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr17_+_35861318 0.269 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr15_+_36179299 0.261 ENSMUST00000047348.3
 Spag1
sperm associated antigen 1
chr7_-_45091713 0.255 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr17_+_35379608 0.245 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chrX_+_42526585 0.233 ENSMUST00000101619.3
 Gm10483
predicted gene 10483
chr19_+_37376359 0.228 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr11_+_61505138 0.202 ENSMUST00000102657.3
 B9d1
B9 protein domain 1
chr17_+_34135182 0.199 ENSMUST00000042121.9
 H2-DMa
histocompatibility 2, class II, locus DMa
chr15_+_36179530 0.198 ENSMUST00000171205.1
 Spag1
sperm associated antigen 1
chr7_-_45092130 0.193 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr1_+_134405984 0.179 ENSMUST00000173908.1
 Cyb5r1
cytochrome b5 reductase 1
chr19_-_4615647 0.174 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr8_+_84969587 0.170 ENSMUST00000109734.1
ENSMUST00000005292.8
 Prdx2

peroxiredoxin 2

chr2_+_163438455 0.157 ENSMUST00000109420.3
ENSMUST00000109421.3
ENSMUST00000018087.6
ENSMUST00000137070.1
 Gdap1l1



ganglioside-induced differentiation-associated protein 1-like 1



chr9_+_44772909 0.151 ENSMUST00000002099.3
 Ift46
intraflagellar transport 46
chr5_+_139150211 0.146 ENSMUST00000026975.6
 Heatr2
HEAT repeat containing 2
chr17_+_34145311 0.145 ENSMUST00000041982.7
 H2-DMb2
histocompatibility 2, class II, locus Mb2
chr5_-_36830647 0.130 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr19_-_10482874 0.130 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr17_-_24886304 0.121 ENSMUST00000044252.5
 Nubp2
nucleotide binding protein 2
chr11_-_3539228 0.120 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
 Smtn



smoothelin



chr17_+_24886643 0.116 ENSMUST00000117890.1
ENSMUST00000168265.1
ENSMUST00000120943.1
ENSMUST00000068508.6
ENSMUST00000119829.1
 Spsb3




splA/ryanodine receptor domain and SOCS box containing 3




chr1_+_194619815 0.115 ENSMUST00000027952.5
 Plxna2
plexin A2
chr2_-_152398046 0.111 ENSMUST00000063332.8
ENSMUST00000182625.1
 Sox12

SRY-box containing gene 12

chr17_+_37270214 0.106 ENSMUST00000038580.6
 H2-M3
histocompatibility 2, M region locus 3
chr9_+_44773191 0.098 ENSMUST00000147559.1
 Ift46
intraflagellar transport 46
chr7_-_101921186 0.096 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
 Lrrc51


leucine rich repeat containing 51


chr17_+_34145231 0.094 ENSMUST00000171231.1
 H2-DMb2
histocompatibility 2, class II, locus Mb2
chr7_+_100537052 0.092 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr4_-_126325641 0.090 ENSMUST00000131113.1
 Tekt2
tektin 2
chr4_+_107968332 0.085 ENSMUST00000106713.3
 Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr2_-_92434027 0.082 ENSMUST00000111278.1
ENSMUST00000090559.5
 Cry2

cryptochrome 2 (photolyase-like)

chr2_+_122147680 0.078 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr3_-_95882193 0.067 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr11_+_98682554 0.066 ENSMUST00000017365.8
 Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr17_+_35439155 0.065 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr7_-_101921175 0.059 ENSMUST00000098236.2
 Lrrc51
leucine rich repeat containing 51
chr7_+_44468020 0.054 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
 Josd2


Josephin domain containing 2


chr7_+_44467980 0.051 ENSMUST00000035844.4
 Josd2
Josephin domain containing 2
chr6_-_83831736 0.051 ENSMUST00000058383.8
 Paip2b
poly(A) binding protein interacting protein 2B
chr19_+_32757497 0.050 ENSMUST00000013807.7
 Pten
phosphatase and tensin homolog
chr17_-_34187219 0.049 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr17_+_34305883 0.047 ENSMUST00000074557.8
 H2-Eb1
histocompatibility 2, class II antigen E beta
chr8_+_94214567 0.044 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr1_-_155146755 0.037 ENSMUST00000027744.8
 Mr1
major histocompatibility complex, class I-related
chr11_+_72441341 0.020 ENSMUST00000045633.5
 Mybbp1a
MYB binding protein (P160) 1a
chr19_-_8819314 0.020 ENSMUST00000096751.4
 Ttc9c
tetratricopeptide repeat domain 9C
chr3_+_16183177 0.017 ENSMUST00000108345.2
ENSMUST00000108346.2
 Ythdf3

YTH domain family 3

chrX_-_160138375 0.013 ENSMUST00000033662.8
 Pdha1
pyruvate dehydrogenase E1 alpha 1
chr7_-_105752193 0.010 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr9_-_51102062 0.009 ENSMUST00000170947.1
 4833427G06Rik
RIKEN cDNA 4833427G06 gene
chr10_-_123196916 0.009 ENSMUST00000020334.7
 Usp15
ubiquitin specific peptidase 15
chr8_-_69996326 0.008 ENSMUST00000177851.1
ENSMUST00000065169.4
 Gatad2a

GATA zinc finger domain containing 2A

chr10_-_7663245 0.008 ENSMUST00000163085.1
ENSMUST00000159917.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr7_+_28179469 0.007 ENSMUST00000085901.6
ENSMUST00000172761.1
 Dyrk1b

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1 0.4 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 0.3 GO:0002339 B cell selection(GO:0002339)
0.1 0.2 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.0 0.3 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 0.2 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.0 0.3 GO:0060539 diaphragm development(GO:0060539)
0.0 0.1 GO:2000832 protein-chromophore linkage(GO:0018298) negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0 0.3 GO:0007141 male meiosis I(GO:0007141)
0.0 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.2 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0042825 TAP complex(GO:0042825)
0.1 0.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.3 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.0 0.5 GO:0042611 MHC protein complex(GO:0042611)
0.0 0.6 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.4 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.1 0.2 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.3 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.7 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.1 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.4 GO:0023026 MHC protein complex binding(GO:0023023) MHC class II protein complex binding(GO:0023026)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)